(Q34448188)

2 August 2017

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title

The role of the AML1 transcription factor in leukemogenesis (English)

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2 August 2017

Lorsbach RB

1

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PubMed ID

11721960

2 August 2017

Downing JR

series ordinal

2

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2 August 2017

1 October 2001

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International Journal of Hematology

2 August 2017

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2 August 2017

74

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2 August 2017

3

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2 August 2017

258-265

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https://scigraph.springernature.com/pub.10.1007/bf02982058

2 August 2017

0 references

cites work

AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis

1 reference

12 December 2020

ETO and AML1 phosphoproteins are expressed in CD34+ hematopoietic progenitors: implications for t(8;21) leukemogenesis and monitoring residual disease

1 reference

12 December 2020

Analysis of the role of AML1-ETO in leukemogenesis, using an inducible transgenic mouse model

1 reference

12 December 2020

Absence of fetal liver hematopoiesis in mice deficient in transcriptional coactivator core binding factor beta

1 reference

12 December 2020

Oligomerization of RAR and AML1 transcription factors as a novel mechanism of oncogenic activation.

1 reference

12 December 2020

Groucho-dependent and -independent repression activities of Runt domain proteins

1 reference

12 December 2020

ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complex

1 reference

12 December 2020

Cloning and characterization of subunits of the T-cell receptor and murine leukemia virus enhancer core-binding factor

1 reference

12 December 2020

Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia

1 reference

12 December 2020

Inhibitors of histone deacetylase relieve ETO-mediated repression and induce differentiation of AML1-ETO leukemia cells

1 reference

12 December 2020

Mutation analysis of core binding factor A1 in patients with cleidocranial dysplasia

1 reference

12 December 2020

Mammalian runt-domain proteins and their roles in hematopoiesis, osteogenesis, and leukemia

1 reference

12 December 2020

The management of neoplastic disorders of haematopoiesis in children with Down's syndrome

1 reference

12 December 2020

Identification of homeotic target genes in Drosophila melanogaster including nervy, a proto-oncogene homologue

1 reference

12 December 2020

Quantitative analysis of AML1/ET0 transcripts in peripheral blood stem cell harvests from patients with t(8;21) acute myelogenous leukaemia

1 reference

12 December 2020

Persistence of multipotent progenitors expressing AML1/ETO transcripts in long-term remission patients with t(8;21) acute myelogenous leukemia

1 reference

12 December 2020

AML1/ETO fusion mRNA can be detected in remission blood samples of all patients with t(8;21) acute myeloid leukemia after chemotherapy or autologous bone marrow transplantation

1 reference

12 December 2020

Linkage of a familial platelet disorder with a propensity to develop myeloid malignancies to human chromosome 21q22.1-22.2

1 reference

12 December 2020

AML1/ETO-expressing nonleukemic stem cells in acute myelogenous leukemia with 8;21 chromosomal translocation

1 reference

12 December 2020

The Ig fold of the core binding factor alpha Runt domain is a member of a family of structurally and functionally related Ig-fold DNA-binding domains

1 reference

12 December 2020

Trisomy 21 in childhood acute lymphoblastic leukemia: a Pediatric Oncology Group study (8602)

1 reference

12 December 2020

Oligomerization of ETO is obligatory for corepressor interaction

1 reference

12 December 2020

The partner gene of AML1 in t(16;21) myeloid malignancies is a novel member of the MTG8(ETO) family.

1 reference

12 December 2020

Interaction and functional cooperation of the leukemia-associated factors AML1 and p300 in myeloid cell differentiation

1 reference

12 December 2020

Trisomy 21 as the sole acquired chromosomal abnormality in children with acute lymphoblastic leukemia

1 reference

12 December 2020

Immunoglobulin motif DNA recognition and heterodimerization of the PEBP2/CBF Runt domain

1 reference

12 December 2020

AML1 gene amplification: a novel finding in childhood acute lymphoblastic leukemia

1 reference

12 December 2020

Dimerization with PEBP2beta protects RUNX1/AML1 from ubiquitin-proteasome-mediated degradation

1 reference

12 December 2020

ALY, a context-dependent coactivator of LEF-1 and AML-1, is required for TCRalpha enhancer function

1 reference

12 December 2020

High incidence of biallelic point mutations in the Runt domain of the AML1/PEBP2 alpha B gene in Mo acute myeloid leukemia and in myeloid malignancies with acquired trisomy 21

1 reference

12 December 2020

CBFA1 Mutation Analysis and Functional Correlation with Phenotypic Variability in Cleidocranial Dysplasia

1 reference

12 December 2020

Embryonic lethality and impairment of haematopoiesis in mice heterozygous for an AML1-ETO fusion gene.

1 reference

12 December 2020

The leukemia-associated AML1 (Runx1)--CBF beta complex functions as a DNA-induced molecular clamp

1 reference

12 December 2020

Evidence for genetic homogeneity in a familial platelet disorder with predisposition to acute myelogenous leukemia (FPD/AML)

1 reference

12 December 2020

A mechanism of repression by acute myeloid leukemia-1, the target of multiple chromosomal translocations in acute leukemia

1 reference

12 December 2020

Mutations involving the transcription factor CBFA1 cause cleidocranial dysplasia

1 reference

12 December 2020

Co-activators and co-repressors in the integration of transcriptional responses

1 reference

12 December 2020

AML1-MTG8 leukemic protein induces the expression of granulocyte colony-stimulating factor (G-CSF) receptor through the up-regulation of CCAAT/enhancer binding protein epsilon.

1 reference

12 December 2020

A WW domain-containing yes-associated protein (YAP) is a novel transcriptional co-activator

1 reference

12 December 2020

Persistence of the 8;21 translocation in patients with acute myeloid leukemia type M2 in long-term remission.

1 reference

12 December 2020

Analysis of genes under the downstream control of the t(8;21) fusion protein AML1-MTG8: overexpression of the TIS11b (ERF-1, cMG1) gene induces myeloid cell proliferation in response to G-CSF

1 reference

12 December 2020

Multiple regions of ETO cooperate in transcriptional repression

1 reference

12 December 2020

Missense mutations abolishing DNA binding of the osteoblast-specific transcription factor OSF2/CBFA1 in cleidocranial dysplasia.

1 reference

12 December 2020

Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors

1 reference

12 December 2020

Amplification of the AML1(CBFA2) gene on ring chromosomes in a patient with acute myeloid leukemia and a constitutional ring chromosome 21

1 reference

12 December 2020

The AML1/ETO fusion protein activates transcription of BCL-2

1 reference

12 December 2020

Synergistic up-regulation of the myeloid-specific promoter for the macrophage colony-stimulating factor receptor by AML1 and the t(8;21) fusion protein may contribute to leukemogenesis

1 reference

12 December 2020

The MYND motif is required for repression of basal transcription from the multidrug resistance 1 promoter by the t(8;21) fusion protein

1 reference

12 December 2020

Mutations of the AML1 gene in myelodysplastic syndrome and their functional implications in leukemogenesis

1 reference

12 December 2020

Amplification of AML1 in childhood acute lymphoblastic leukemias

1 reference

12 December 2020

The ETO protein disrupted in t(8;21)-associated acute myeloid leukemia is a corepressor for the promyelocytic leukemia zinc finger protein

1 reference

12 December 2020

Leukaemia disease genes: large-scale cloning and pathway predictions

1 reference

12 December 2020

Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis

1 reference

12 December 2020

Structural analyses of DNA recognition by the AML1/Runx-1 Runt domain and its allosteric control by CBFbeta

1 reference

12 December 2020

Biallelic and heterozygous point mutations in the runt domain of the AML1/PEBP2alphaB gene associated with myeloblastic leukemias

1 reference

12 December 2020

Expression of a knocked-in AML1-ETO leukemia gene inhibits the establishment of normal definitive hematopoiesis and directly generates dysplastic hematopoietic progenitors.

1 reference

12 December 2020

AML-1/ETO fusion protein is a dominant negative inhibitor of transcriptional repression by the promyelocytic leukemia zinc finger protein

1 reference

12 December 2020

Studies of a familial platelet disorder

1 reference

12 December 2020

Molecular cloning and characterization of PEBP2 beta, the heterodimeric partner of a novel Drosophila runt-related DNA binding protein PEBP2 alpha

1 reference

12 December 2020

PEBP2/PEA2 represents a family of transcription factors homologous to the products of the Drosophila runt gene and the human AML1 gene

1 reference

12 December 2020

Identification of two transcripts of AML1/ETO-fused gene in t(8;21) leukemic cells and expression of wild-type ETO gene in hematopoietic cells

1 reference

12 December 2020

Histone deacetylase-targeted treatment restores retinoic acid signaling and differentiation in acute myeloid leukemia

1 reference

12 December 2020

The CBFbeta subunit is essential for CBFalpha2 (AML1) function in vivo

1 reference

12 December 2020

A fatal myeloproliferative syndrome in a family with thrombocytopenia and platelet dysfunction

1 reference

12 December 2020

The AML1-MTG8 leukemic fusion protein forms a complex with a novel member of the MTG8(ETO/CDR) family, MTGR1

1 reference

12 December 2020

Chromosomal abnormalities in 478 children with acute myeloid leukemia: clinical characteristics and treatment outcome in a cooperative pediatric oncology group study-POG 8821

1 reference

12 December 2020

The AML1-ETO chimaeric transcription factor in acute myeloid leukaemia: biology and clinical significance

1 reference

12 December 2020

Cbfa1: a molecular switch in osteoblast biology

1 reference

12 December 2020

The Runt domain identifies a new family of heteromeric transcriptional regulators.

1 reference

12 December 2020

Identifiers

DOI

10.1007/BF02982058

1 reference

PubMed ID

11721960

Dimensions Publication ID

2 August 2017

0 references

1 reference

PubMed ID

11721960