(Q34453159)

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Molecular perspectives on selective estrogen receptor modulators (SERMs): progress in understanding their tissue-specific agonist and antagonist actions

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scholarly article

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Europe PubMed Central

2 August 2017

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Europe PubMed Central

Molecular perspectives on selective estrogen receptor modulators (SERMs): progress in understanding their tissue-specific agonist and antagonist actions (English)

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Europe PubMed Central

2 August 2017

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David M Lonard

1

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Europe PubMed Central

2 August 2017

Carolyn L Smith

2

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Europe PubMed Central

2 August 2017

publication date

1 January 2002

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Europe PubMed Central

2 August 2017

1 reference

Europe PubMed Central

2 August 2017

67

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Europe PubMed Central

2 August 2017

15-24

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Europe PubMed Central

2 August 2017

1

1 reference

Europe PubMed Central

2 August 2017

Estrogen receptor transcription and transactivation: Estrogen receptor knockout mice: what their phenotypes reveal about mechanisms of estrogen action

1 reference

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7 January 2021

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Coronary Artery Disease in Postmenopausal Women

1 reference

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7 January 2021

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inferred from DOI database lookup

Molecular mechanisms of action of steroid/thyroid receptor superfamily members

1 reference

https://api.crossref.org/works/10.1016%2FS0039-128X%2801%2900133-7

7 January 2021

based on heuristic

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Defining a minimal estrogen receptor DNA binding domain

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7 January 2021

based on heuristic

inferred from DOI database lookup

Tamoxifen activation of the estrogen receptor/AP-1 pathway: potential origin for the cell-specific estrogen-like effects of antiestrogens

1 reference

https://api.crossref.org/works/10.1016%2FS0039-128X%2801%2900133-7

7 January 2021

based on heuristic

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Sequence and characterization of a coactivator for the steroid hormone receptor superfamily

1 reference

https://api.crossref.org/works/10.1016%2FS0039-128X%2801%2900133-7

7 January 2021

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The SRC family of nuclear receptor coactivators

1 reference

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7 January 2021

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Nuclear receptor coregulators: cellular and molecular biology

1 reference

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7 January 2021

based on heuristic

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Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

A transcriptional co-repressor that interacts with nuclear hormone receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0039-128X%2801%2900133-7

7 January 2021

based on heuristic

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Nuclear receptor repression mediated by a complex containing SMRT, mSin3A, and histone deacetylase

1 reference

https://api.crossref.org/works/10.1016%2FS0039-128X%2801%2900133-7

7 January 2021

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Cloning of a novel receptor expressed in rat prostate and ovary

1 reference

https://api.crossref.org/works/10.1016%2FS0039-128X%2801%2900133-7

7 January 2021

based on heuristic

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Partial hormone resistance in mice with disruption of the steroid receptor coactivator-1 (SRC-1) gene

1 reference

https://api.crossref.org/works/10.1016%2FS0039-128X%2801%2900133-7

7 January 2021

based on heuristic

inferred from DOI database lookup

The steroid receptor coactivator SRC-3 (p/CIP/RAC3/AIB1/ACTR/TRAM-1) is required for normal growth, puberty, female reproductive function, and mammary gland development

1 reference

https://api.crossref.org/works/10.1016%2FS0039-128X%2801%2900133-7

7 January 2021

based on heuristic

inferred from DOI database lookup

AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0039-128X%2801%2900133-7

7 January 2021

based on heuristic

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The nuclear receptor ligand-binding domain: structure and function.

1 reference

https://api.crossref.org/works/10.1016%2FS0039-128X%2801%2900133-7

7 January 2021

based on heuristic

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AF-2 activity and recruitment of steroid receptor coactivator 1 to the estrogen receptor depend on a lysine residue conserved in nuclear receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0039-128X%2801%2900133-7

7 January 2021

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The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen

1 reference

https://api.crossref.org/works/10.1016%2FS0039-128X%2801%2900133-7

7 January 2021

based on heuristic

inferred from DOI database lookup

A signature motif in transcriptional co-activators mediates binding to nuclear receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0039-128X%2801%2900133-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Molecular determinants of the estrogen receptor-coactivator interface

1 reference

https://api.crossref.org/works/10.1016%2FS0039-128X%2801%2900133-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Molecular basis of agonism and antagonism in the oestrogen receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0039-128X%2801%2900133-7

7 January 2021

based on heuristic

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Estrogen receptor (ER) modulators each induce distinct conformational changes in ER alpha and ER beta.

1 reference

https://api.crossref.org/works/10.1016%2FS0039-128X%2801%2900133-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Peptide antagonists of the human estrogen receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0039-128X%2801%2900133-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Structure of the ligand-binding domain of oestrogen receptor beta in the presence of a partial agonist and a full antagonist

1 reference

https://api.crossref.org/works/10.1016%2FS0039-128X%2801%2900133-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Characterization of the Amino-terminal Transcriptional Activation Function of the Human Estrogen Receptor in Animal and Yeast Cells

1 reference

https://api.crossref.org/works/10.1016%2FS0039-128X%2801%2900133-7

7 January 2021

based on heuristic

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Identification of an estrogen response element activated by metabolites of 17beta-estradiol and raloxifene

1 reference

https://api.crossref.org/works/10.1016%2FS0039-128X%2801%2900133-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Differential ligand activation of estrogen receptors ERalpha and ERbeta at AP1 sites

1 reference

https://api.crossref.org/works/10.1016%2FS0039-128X%2801%2900133-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Estrogen receptor pathways to AP-1.

1 reference

https://api.crossref.org/works/10.1016%2FS0039-128X%2801%2900133-7

7 January 2021

based on heuristic

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Membrane binding sites and non-genomic effects of estrogen in cultured human pre-osteoclastic cells

1 reference

https://api.crossref.org/works/10.1016%2FS0039-128X%2801%2900133-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Mechanisms of estrogen action in the cardiovascular system

1 reference

https://api.crossref.org/works/10.1016%2FS0039-128X%2801%2900133-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Mapping of neural and signal transduction pathways for lordosis in the search for estrogen actions on the central nervous system

1 reference

https://api.crossref.org/works/10.1016%2FS0039-128X%2801%2900133-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Repression of the interleukin-6 promoter by estrogen receptor is mediated by NF-kappa B and C/EBP beta

1 reference

https://api.crossref.org/works/10.1016%2FS0039-128X%2801%2900133-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Ligand-dependent repression of the erythroid transcription factor GATA-1 by the estrogen receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0039-128X%2801%2900133-7

7 January 2021

based on heuristic

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Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0039-128X%2801%2900133-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Epidermal growth factor partially reverses the inhibitory effects of antiestrogens on T 47D human breast cancer cell growth

1 reference

https://api.crossref.org/works/10.1016%2FS0039-128X%2801%2900133-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Changes in epidermal growth factor receptor expression and response to ligand associated with acquired tamoxifen resistance or oestrogen independence in the ZR-75-1 human breast cancer cell line

1 reference

https://api.crossref.org/works/10.1016%2FS0039-128X%2801%2900133-7

7 January 2021

based on heuristic

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Phosphorylation of steroid receptor coactivator-1. Identification of the phosphorylation sites and phosphorylation through the mitogen-activated protein kinase pathway.

1 reference

https://api.crossref.org/works/10.1016%2FS0039-128X%2801%2900133-7

7 January 2021

based on heuristic

inferred from DOI database lookup

AIB1 is a conduit for kinase-mediated growth factor signaling to the estrogen receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0039-128X%2801%2900133-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Ligand-independent recruitment of SRC-1 to estrogen receptor beta through phosphorylation of activation function AF-1

1 reference

https://api.crossref.org/works/10.1016%2FS0039-128X%2801%2900133-7

7 January 2021

based on heuristic

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Coactivator and corepressor complexes in nuclear receptor function

1 reference

https://api.crossref.org/works/10.1016%2FS0039-128X%2801%2900133-7

7 January 2021

based on heuristic

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Diverse signaling pathways modulate nuclear receptor recruitment of N-CoR and SMRT complexes

1 reference

https://api.crossref.org/works/10.1016%2FS0039-128X%2801%2900133-7

7 January 2021

based on heuristic

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Cofactor dynamics and sufficiency in estrogen receptor-regulated transcription

1 reference

https://api.crossref.org/works/10.1016%2FS0039-128X%2801%2900133-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Coactivator and corepressor regulation of the agonist/antagonist activity of the mixed antiestrogen, 4-hydroxytamoxifen.

1 reference

https://api.crossref.org/works/10.1016%2FS0039-128X%2801%2900133-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Combinatorial roles of the nuclear receptor corepressor in transcription and development

1 reference

https://api.crossref.org/works/10.1016%2FS0039-128X%2801%2900133-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Analysis of estrogen receptor transcriptional enhancement by a nuclear hormone receptor coactivator

1 reference

https://api.crossref.org/works/10.1016%2FS0039-128X%2801%2900133-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Estrogen receptor activation function 1 works by binding p160 coactivator proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0039-128X%2801%2900133-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Purification and identification of p68 RNA helicase acting as a transcriptional coactivator specific for the activation function 1 of human estrogen receptor alpha

1 reference

https://api.crossref.org/works/10.1016%2FS0039-128X%2801%2900133-7

7 January 2021

based on heuristic

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Estrogen-binding substances of target tissues

1 reference

https://api.crossref.org/works/10.1016%2FS0039-128X%2801%2900133-7

7 January 2021

based on heuristic

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Comparative analyses of mechanistic differences among antiestrogens

1 reference

https://api.crossref.org/works/10.1016%2FS0039-128X%2801%2900133-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Proteasome-dependent degradation of the human estrogen receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0039-128X%2801%2900133-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Implication of proteasome in estrogen receptor degradation

1 reference

https://api.crossref.org/works/10.1016%2FS0039-128X%2801%2900133-7

7 January 2021

based on heuristic

inferred from DOI database lookup

The ubiquitin-proteasome pathway is required for processing the NF-kappa B1 precursor protein and the activation of NF-kappa B

1 reference

https://api.crossref.org/works/10.1016%2FS0039-128X%2801%2900133-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Regulation of interferon-gamma-activated STAT1 by the ubiquitin-proteasome pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0039-128X%2801%2900133-7

7 January 2021

based on heuristic

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Degradation of nuclear oncoproteins by the ubiquitin system in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0039-128X%2801%2900133-7

7 January 2021

based on heuristic

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Structure and functions of the 20S and 26S proteasomes

1 reference

https://api.crossref.org/works/10.1016%2FS0039-128X%2801%2900133-7

7 January 2021

based on heuristic

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The proteasome: paradigm of a self-compartmentalizing protease

1 reference

https://api.crossref.org/works/10.1016%2FS0039-128X%2801%2900133-7

7 January 2021

based on heuristic

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The 26S proteasome is required for estrogen receptor-alpha and coactivator turnover and for efficient estrogen receptor-alpha transactivation

1 reference

https://api.crossref.org/works/10.1016%2FS0039-128X%2801%2900133-7

7 January 2021

based on heuristic

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Retinoic acid induces proteasome-dependent degradation of retinoic acid receptor alpha (RARalpha) and oncogenic RARalpha fusion proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0039-128X%2801%2900133-7

7 January 2021

based on heuristic

inferred from DOI database lookup

The Angelman syndrome-associated protein, E6-AP, is a coactivator for the nuclear hormone receptor superfamily

1 reference

https://api.crossref.org/works/10.1016%2FS0039-128X%2801%2900133-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Interaction of thyroid-hormone receptor with a conserved transcriptional mediator

1 reference

https://api.crossref.org/works/10.1016%2FS0039-128X%2801%2900133-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Interaction of the Ubc9 human homologue with c-Jun and with the glucocorticoid receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0039-128X%2801%2900133-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Ubc9 interacts with the androgen receptor and activates receptor-dependent transcription

1 reference

https://api.crossref.org/works/10.1016%2FS0039-128X%2801%2900133-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Antiestrogen ICI 164,384 reduces cellular estrogen receptor content by increasing its turnover

1 reference

https://api.crossref.org/works/10.1016%2FS0039-128X%2801%2900133-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Different classes of coactivators recognize distinct but overlapping binding sites on the estrogen receptor ligand binding domain

1 reference

https://api.crossref.org/works/10.1016%2FS0039-128X%2801%2900133-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Ligand-dependent interactions of coactivators steroid receptor coactivator-1 and peroxisome proliferator-activated receptor binding protein with nuclear hormone receptors can be imaged in live cells and are required for transcription

1 reference

https://api.crossref.org/works/10.1016%2FS0039-128X%2801%2900133-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Structural insights into the mode of action of a pure antiestrogen

1 reference

https://api.crossref.org/works/10.1016%2FS0039-128X%2801%2900133-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1016/S0039-128X(01)00133-7

1 reference

Europe PubMed Central

2 August 2017

1 reference

Europe PubMed Central

2 August 2017

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