(Q34455213)

English

Chloroquine or chloroquine-PI3K/Akt pathway inhibitor combinations strongly promote γ-irradiation-induced cell death in primary stem-like glioma cells

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scholarly article

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Europe PubMed Central

PubMed publication ID

2 August 2017

Chloroquine or chloroquine-PI3K/Akt pathway inhibitor combinations strongly promote γ-irradiation-induced cell death in primary stem-like glioma cells (English)

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Europe PubMed Central

PubMed publication ID

2 August 2017

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author name string

Elke Firat

1

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

Astrid Weyerbrock

2

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

Simone Gaedicke

3

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

Anca-Ligia Grosu

4

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

Gabriele Niedermann

5

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Europe PubMed Central

PubMed publication ID

2 August 2017

language of work or name

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publication date

16 October 2012

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Europe PubMed Central

PubMed publication ID

2 August 2017

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

7

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

10

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

e47357

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

copyright license

Creative Commons Attribution 4.0 International

16 October 2012

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April 2022 Public Data File from Crossref

copyright status

0 references

Novel therapies in glioblastoma

1 reference

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6 July 2018

Delayed cell death associated with mitotic catastrophe in γ-irradiated stem-like glioma cells

1 reference

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1 reference

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6 July 2018

Pancreatic cancers require autophagy for tumor growth

1 reference

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6 July 2018

Oncogenic Ras-induced expression of Noxa and Beclin-1 promotes autophagic cell death and limits clonogenic survival

1 reference

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Principles and current strategies for targeting autophagy for cancer treatment

1 reference

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6 July 2018

Akt and autophagy cooperate to promote survival of drug-resistant glioma

1 reference

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6 July 2018

Seeing is believing: are cancer stem cells the Loch Ness monster of tumor biology?

1 reference

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6 July 2018

Therapeutic exploitation of apoptosis and autophagy for glioblastoma

1 reference

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6 July 2018

Targeting the RTK-PI3K-mTOR axis in malignant glioma: overcoming resistance

1 reference

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6 July 2018

Chloroquine-induced autophagic vacuole accumulation and cell death in glioma cells is p53 independent

1 reference

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6 July 2018

Akt signaling pathway: a target for radiosensitizing human malignant glioma.

1 reference

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6 July 2018

Chloroquine activates the p53 pathway and induces apoptosis in human glioma cells

1 reference

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6 July 2018

Preclinical evaluation of radiation and perifosine in a genetically and histologically accurate model of brainstem glioma

1 reference

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The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway

1 reference

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Methods in mammalian autophagy research

1 reference

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Selective targeting of radiation-resistant tumor-initiating cells

1 reference

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6 July 2018

Glioma stem cell lines expanded in adherent culture have tumor-specific phenotypes and are suitable for chemical and genetic screens

1 reference

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6 July 2018

Molecular pharmacology of phosphatidylinositol 3-kinase inhibition in human glioma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3473017

6 July 2018

PI3K signaling in glioma--animal models and therapeutic challenges

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3473017

6 July 2018

Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3473017

6 July 2018

Brain cancer stem cells display preferential sensitivity to Akt inhibition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3473017

6 July 2018

Class I PI3 kinase inhibition by the pyridinylfuranopyrimidine inhibitor PI-103 enhances tumor radiosensitivity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3473017

6 July 2018

Chloroquine: novel uses & manifestations.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3473017

6 July 2018

Survival following CyberKnife radiosurgery and hypofractionated radiotherapy for newly diagnosed glioblastoma multiforme

1 reference

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6 July 2018

PI3K pathway regulates survival of cancer stem cells residing in the perivascular niche following radiation in medulloblastoma in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3473017

6 July 2018

Randomized dose-ranging controlled trial of AQ-13, a candidate antimalarial, and chloroquine in healthy volunteers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3473017

6 July 2018

A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3473017

6 July 2018

Adding chloroquine to conventional treatment for glioblastoma multiforme: a randomized, double-blind, placebo-controlled trial

1 reference

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6 July 2018

Chloroquine-mediated radiosensitization is due to the destabilization of the lysosomal membrane and subsequent induction of cell death by necrosis.

1 reference

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The apoptosis/autophagy paradox: autophagic vacuolization before apoptotic death

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Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma

1 reference

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Therapy of glioblastoma multiforme improved by the antimutagenic chloroquine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3473017

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Inhibition of macroautophagy triggers apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3473017

6 July 2018

Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3473017

6 July 2018

Mitochondrial membrane permeabilization is a critical step of lysosome-initiated apoptosis induced by hydroxychloroquine.

1 reference

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6 July 2018

Chloroquine-induced neuronal cell death is p53 and Bcl-2 family-dependent but caspase-independent

1 reference

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1 reference

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1 reference

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Potentiation of radiation lethality in HeLa cells by combined mild hyperthermia and chloroquine

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1 reference

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1 reference

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c-Src-p38 mitogen-activated protein kinase signaling is required for Akt activation in response to ionizing radiation

1 reference

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1 reference

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27 October 2018

Inhibition of Akt by the alkylphospholipid perifosine does not enhance the radiosensitivity of human glioma cells.

1 reference

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Notch promotes radioresistance of glioma stem cells

1 reference

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12 December 2020

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10.1371/JOURNAL.PONE.0047357

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

2012PLoSO...747357F

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PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

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