(Q34455931)

25547199

2 August 2017

title

N-Benzyl-5-methoxytryptamines as Potent Serotonin 5-HT2 Receptor Family Agonists and Comparison with a Series of Phenethylamine Analogues (English)

1 reference

2 August 2017

0 references

5

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25547199%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

author name string

David E Nichols

1

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12 June 2020

M Flori Sassano

2

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12 June 2020

Adam L Halberstadt

3

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12 June 2020

Landon M Klein

4

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12 June 2020

Simon P Elliott

6

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12 June 2020

Wolfgang J Fiedler

7

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12 June 2020

publication date

21 January 2015

1 reference

25547199

ACS Chemical Neuroscience

2 August 2017

published in

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12 June 2020

volume

6

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12 June 2020

issue

7

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12 June 2020

page(s)

1165-1175

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Hallucinogen-like effects of 2-([2-(4-cyano-2,5-dimethoxyphenyl) ethylamino]methyl)phenol (25CN-NBOH), a novel N-benzylphenethylamine with 100-fold selectivity for 5-HT₂A receptors, in mice

12 June 2020

cites work

1 reference

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2C-I-NBOMe, an "N-bomb" that kills with "Smiles". Toxicological and legislative aspects

6 July 2018

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The NBOMe hallucinogenic drug series: Patterns of use, characteristics of users and self-reported effects in a large international sample

6 July 2018

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Synthesis and structure-activity relationships of N-benzyl phenethylamines as 5-HT2A/2C agonists.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505863

Postmortem detection of 25I-NBOMe [2-(4-iodo-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine] in fluids and tissues determined by high performance liquid chromatography with tandem mass spectrometry from a traumatic death

6 July 2018

1 reference

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Effects of the hallucinogen 2,5-dimethoxy-4-iodophenethylamine (2C-I) and superpotent N-benzyl derivatives on the head twitch response

6 July 2018

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Characterization of the head-twitch response induced by hallucinogens in mice: detection of the behavior based on the dynamics of head movement

6 July 2018

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Extensive rigid analogue design maps the binding conformation of potent N-benzylphenethylamine 5-HT2A serotonin receptor agonist ligands

6 July 2018

1 reference

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Differential contributions of serotonin receptors to the behavioral effects of indoleamine hallucinogens in mice

6 July 2018

1 reference

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Theoretical studies on the interaction of partial agonists with the 5-HT2A receptor

6 July 2018

1 reference

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Interaction of 5-HT2A and 5-HT2C receptors in R(-)-2,5-dimethoxy-4-iodoamphetamine-elicited head twitch behavior in mice

6 July 2018

1 reference

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The serotonin 2C receptor potently modulates the head-twitch response in mice induced by a phenethylamine hallucinogen

6 July 2018

1 reference

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A selective positive allosteric modulator of metabotropic glutamate receptor subtype 2 blocks a hallucinogenic drug model of psychosis

6 July 2018

1 reference

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Molecular interaction of serotonin 5-HT2A receptor residues Phe339(6.51) and Phe340(6.52) with superpotent N-benzyl phenethylamine agonists

6 July 2018

1 reference

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Hallucinogen-like actions of 2,5-dimethoxy-4-(n)-propylthiophenethylamine (2C-T-7) in mice and rats

6 July 2018

1 reference

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Reductive Amination of Aldehydes and Ketones with Sodium Triacetoxyborohydride. Studies on Direct and Indirect Reductive Amination Procedures(1).

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505863

N(1)-substituted ergolines and tryptamines show species differences for the agonist-labeled 5-HT2 receptor

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505863

Species variations in transmembrane region V of the 5-hydroxytryptamine type 2A receptor alter the structure-activity relationship of certain ergolines and tryptamines

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505863

Influence of amine substituents on 5-HT2A versus 5-HT2C binding of phenylalkyl- and indolylalkylamines

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505863

A potent competitive inhibitor of 5-hydroxytryptamine: 3-(2'-benzylaminoethyl)-5-methoxyindol hydrochloride

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505863

A possible correlation between drug-induced hallucinations in man and a behavioural response in mice

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505863

The classification of peripheral 5-HT2-like receptors using tryptamine agonist and antagonist analogues

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505863

Withdrawal from chronic treatment with (+/-)-DOI causes super-sensitivity to 5-HT2 receptor-induced head-twitch behaviour in mice

6 July 2018

1 reference

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Synthesis and body distribution of several iodine-131-labeled central nervous system active drugs

6 July 2018

1 reference

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‘Wet-Dog’ shake behaviour in the rat: A possible quantitative model of central 5-hydroxytryptamine activity☆

6 July 2018

1 reference

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Pathological findings in 2 cases of fatal 25I-NBOMe toxicity.

6 July 2018

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Hallucinogen-like actions of 5-methoxy-N,N-diisopropyltryptamine in mice and rats

27 October 2018

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Pharmacological profile of a model for central serotonin receptor activation

27 October 2018

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12 December 2020

Correlating the metabolic stability of psychedelic 5-HT₂A agonists with anecdotal reports of human oral bioavailability

1 reference

12 December 2020

Assessment of the roles of serines 5.43(239) and 5.46(242) for binding and potency of agonist ligands at the human serotonin 5-HT2A receptor

1 reference

12 December 2020

Pharmacological and behavioral characterization of the 5-HT2A receptor in C57BL/6N mice

1 reference

12 December 2020

Identifiers

DOI

10.1021/CN500292D

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25547199%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25547199%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

25547199

1 reference