(Q34462487)

2 August 2017

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title

Full-speed mammalian genetics: in vivo target validation in the drug discovery process (English)

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2 August 2017

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Alejandro Abuin

1

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2 August 2017

Kathleen H Holt

2

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2 August 2017

Kenneth A Platt

3

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2 August 2017

Arthur T Sands

4

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2 August 2017

Brian P Zambrowicz

5

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2 August 2017

publication date

1 January 2002

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2 August 2017

published in

Trends in Biotechnology

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2 August 2017

volume

20

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2 August 2017

issue

1

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2 August 2017

page(s)

36-42

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Initial sequencing and analysis of the human genome

2 August 2017

cites work

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7 January 2021

A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse

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Transgenic knockouts as part of high-throughput, evidence-based target selection and validation strategies

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The interferon system and interferon regulatory factor transcription factors -- studies from gene knockout mice

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Murine tumor suppressor models

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Dissecting the role of the serotonin system in neuropsychiatric disorders using knockout mice

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7 January 2021

KO's and organisation of peptidergic feeding behavior mechanisms

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7 January 2021

Mouse models of hyperlipidemia and atherosclerosis

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7 January 2021

Genetic models of obesity and energy balance in the mouse

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7 January 2021

Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration.

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7 January 2021

Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor

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7 January 2021

Mice lacking the beta3 subunit of the GABAA receptor have the epilepsy phenotype and many of the behavioral characteristics of Angelman syndrome.

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7 January 2021

Dramatic growth of mice that develop from eggs microinjected with metallothionein-growth hormone fusion genes

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7 January 2021

Osteopetrosis and osteoporosis: two sides of the same coin

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7 January 2021

Cathepsin K and the design of inhibitors of cathepsin K.

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7 January 2021

Impaired osteoclastic bone resorption leads to osteopetrosis in cathepsin-K-deficient mice

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7 January 2021

Targeted disruption of the melanocortin-4 receptor results in obesity in mice

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7 January 2021

Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass

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7 January 2021

Role of the melanocortin-4 receptor in metabolic rate and food intake in mice

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7 January 2021

The lac operator-repressor system is functional in the mouse

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7 January 2021

Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2

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7 January 2021

Increased anxiety and impaired pain response in puromycin-sensitive aminopeptidase gene-deficient mice obtained by a mouse gene-trap method.

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7 January 2021

Specific inhibitor of puromycin-sensitive aminopeptidase with a homophthalimide skeleton: identification of the target molecule and a structure-activity relationship study

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7 January 2021

The Sequence of the Human Genome

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7 January 2021

Construction of gene targeting vectors from lambda KOS genomic libraries

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7 January 2021

Simplified generation of targeting constructs using ET recombination

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7 January 2021

P-element-mediated enhancer detection: a versatile method to study development in Drosophila.

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7 January 2021

Mouse embryonic stem cells and reporter constructs to detect developmentally regulated genes.

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7 January 2021

Detection in situ of genomic regulatory elements in Drosophila

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7 January 2021

Functional genomics in mice by tagged sequence mutagenesis

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7 January 2021

An efficient gene-trap method using poly A trap vectors and characterization of gene-trap events

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7 January 2021

Combining mutagenesis and genomics in the mouse--closing the phenotype gap.

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7 January 2021

Chromosomal deletion complexes in mice by radiation of embryonic stem cells

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7 January 2021

Disruption and sequence identification of 2,000 genes in mouse embryonic stem cells

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7 January 2021

Defining brain wiring patterns and mechanisms through gene trapping in mice.

1 reference

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7 January 2021

Tsg101: a novel tumor susceptibility gene isolated by controlled homozygous functional knockout of allelic loci in mammalian cells

1 reference

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7 January 2021

Gene trapping in differentiating cell lines: regulation of the lysosomal protease cathepsin B in skeletal myoblast growth and fusion

1 reference

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7 January 2021

A gene trap approach in mouse embryonic stem cells: the lacZ reported is activated by splicing, reflects endogenous gene expression, and is mutagenic in mice

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7 January 2021

Establishment of a gene-trap sequence tag library to generate mutant mice from embryonic stem cells

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7 January 2021

Genome-wide, large-scale production of mutant mice by ENU mutagenesis.

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7 January 2021

SHIRPA, a protocol for behavioral assessment: validation for longitudinal study of neurological dysfunction in mice.

1 reference

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7 January 2021

10.1016/S0167-7799(01)01843-1

Identifiers

DOI

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2 August 2017

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