(Q34473755)

2 August 2017

The effects of age and liver disease on the disposition and elimination of diazepam in adult man (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1127104

24 August 2022

0 references

1 reference

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1127104

24 August 2022

author name string

U. Klotz

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1127104

24 August 2022

G. R. Avant

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1127104

24 August 2022

A. Hoyumpa

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1127104

24 August 2022

S. Schenker

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1127104

24 August 2022

G. R. Wilkinson

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1127104

24 August 2022

language of work or name

English

0 references

publication date

1 February 1975

1 reference

full work available at URL

2 August 2017

https://europepmc.org/articles/PMC301753

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1127104

https://europepmc.org/articles/PMC301753?pdf=render

24 August 2022

file format

Portable Document Format

online access status

open access

content deliverer

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1127104

http://www.jci.org/articles/view/107938/files/pdf

24 August 2022

file format

Portable Document Format

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1127104

http://www.jci.org/articles/view/107938/files/pdf

7 October 2023

1 reference

https://api.crossref.org/works/10.1172/JCI107938

Journal of Clinical Investigation

7 October 2023

published in

1 reference

2 August 2017

55

1 reference

2 August 2017

347-359

1 reference

2 August 2017

2

1 reference

Persistence of antibiotics in blood of patients with acute renal failure. II. Chloramphenicol and its metabolic products in the blood of patients with severe renal disease or hepatic cirrhosis

2 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=301753

PHARMACOLOGIC ASPECTS OF AGING: A SURVEY OF THE EFFECT OF INCREASING AGE ON DRUG ACTIVITY IN ADULTS

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=301753

Metabolism of diazepam in vitro.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=301753

Effect of Age and Sex on Human Drug Metabolism

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=301753

Determination of medazepam (nobrium), diazepam(valium) and their major biotransformation products in blod and urine by electron capture s-liquid chromatography.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=301753

Time Integral of Drug Concentration in the Central (Plasma) Compartment

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=301753

Further studies on species difference in diazepam metabolism

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=301753

The metabolism of diazepam by liver microsomal enzymes of rats and mice

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=301753

Blood level distribution patterns of diazepam and its major metabolite in man.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=301753

Influence of acute and chronic nicotine administration on EEG reactivity to drugs in rabbits. 2. Psychoactive agents

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=301753

Pharmacokinetics of Diazepam in Dogs, Mice and Humans

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=301753

Clinical and Electroencephalographic Assessment of Diazepam in Liver Disease

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=301753

Kinetics of rifampicin and isoniazid administered alone and in combination to normal subjects and patients with liver disease

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=301753

Determination of bioavailability of diazepam in various formulations from steady state plasma concentration data

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=301753

Effects of change in elimination on varous parameters of the two-compartment open model.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=301753

Metabolism of amylobarbitone in patients with chronic liver disease

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=301753

Pharmacokinetics of distribution and metabolism of ataractic drugs and an evaluation of the site of antianxiety activity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=301753

Diazepam elimination in premature and full term infants, and children.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=301753

Clearance concepts in pharmacokinetics

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=301753

Determinants of serum antipyrine half-lives in patients with liver disease

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=301753

Lidocaine Pharmacokinetics in Advanced Heart Failure, Liver Disease, and Renal Failure in Humans

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=301753

Rate of Aminopyrine Disappearance from Plasma in Young and Aged Humans

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=301753

Microsomal Pentobarbital Hydroxylase Activity in Acute Viral Hepatitis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=301753

Metabolism of diazepam in isolated perfused liver of rat and mouse.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=301753

VARIATION IN THE ACTIVITY OF LIVER MICROSOMAL DRUG-METABOLIZING ENZYMES IN RATS IN RELATION TO THE AGE.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=301753

Pharmacological and clinical studies on Valium (T.M.) a new psychotherapeutic agent of the benzodiazepine class.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=301753

Metabolism of diazepam in rat, dog, and man.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=301753

Species difference in diazepam metabolism and anticonvulsant effect

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=301753

Correlation between the duration of the anticonvulsant activity of diazepam and its physiological disposition in mice.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=301753

Metabolism of drugs in old rats. II. Metabolism in vivo and effect of drugs in old rats

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=301753

Pharmacokinetic profile of diazepam in man following single intravenous and oral and chronic oral administrations.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=301753

The disposition of propranolol. 8. General implications of the effects of liver blood flow on elimination from the perfused rat liver

27 October 2018

1 reference

12 December 2020

Determination of drug metabolizing enzymes in needle biopsies of human liver

1 reference

12 December 2020

The disposition of propranolol. 3. Decreased half-life and volume of distribution as a result of plasma binding in man, monkey, dog and rat

1 reference

12 December 2020

The effect of cirrhosis on the disposition and elimination of meperidine in man

1 reference

12 December 2020

Diazepam metabolism during chronic medication unbound fraction in plasma, erythrocytes and urine

1 reference

12 December 2020

Pharmacodynamic consequences of aging and their implications in the treatment of the elderly patient

1 reference

12 December 2020

THE EFFECT OF INCREASING AGE ON THE DISTRIBUTION OF PERIPHERAL BLOOD FLOW IN MAN

1 reference

12 December 2020

DISAPPEARANCE RATE OF TOLBUTAMIDE IN NORMAL SUBJECTS AND IN DIABETES MELLITUS, LIVER CIRRHOSIS, AND RENAL DISEASE

1 reference

12 December 2020

Pharmacodynamics of Carbenicillin in Hepatic and Renal Failure

1 reference

12 December 2020

Effect of experimental hepatic injury on the clearance of phenobarbital and paraldehyde

1 reference

12 December 2020

Phenylbutazone and isoniazid metabolism in patients with liver disease in relation to previous drug therapy

1 reference

12 December 2020

Concept of a Volume of Distribution and Possible Errors in Evaluation of This Parameter

1 reference

12 December 2020

Shortcomings in Pharmacokinetic Analysis by Conceiving the Body to Exhibit Properties of a Single Compartment

1 reference

12 December 2020

Identifiers

DOI

10.1172/JCI107938

1 reference

2 August 2017

1 reference

2 August 2017

1 reference