(Q34482695)

2 August 2017

title

Paeoniflorin protects against ischemia-induced brain damages in rats via inhibiting MAPKs/NF-κB-mediated inflammatory responses (English)

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2 August 2017

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Ruo-Bing Guo

1

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2 August 2017

Guo-Feng Wang

2

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2 August 2017

An-Peng Zhao

3

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2 August 2017

Jun Gu

4

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2 August 2017

Xiu-Lan Sun

5

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2 August 2017

Gang Hu

6

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2 August 2017

language of work or name

English

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publication date

14 November 2012

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2 August 2017

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2 August 2017

volume

7

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2 August 2017

issue

11

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2 August 2017

page(s)

e49701

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Creative Commons Attribution 4.0 International

2 August 2017

copyright license

start time

14 November 2012

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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6 July 2018

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6 July 2018

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6 July 2018

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Targeting ischemic penumbra Part I: from pathophysiology to therapeutic strategy

6 July 2018

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6 July 2018

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Cerebral ischemia induces microvascular pro-inflammatory cytokine expression via the MEK/ERK pathway

6 July 2018

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Anti-apoptotic actions of PPAR-gamma against ischemic stroke

6 July 2018

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Molecules that modulate Apaf-1 activity

6 July 2018

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Tumor necrosis factor-alpha impairs the recovery of synaptic transmission from hypoxia in rat hippocampal slices

6 July 2018

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Mitochondrial targets for stroke: focusing basic science research toward development of clinically translatable therapeutics

6 July 2018

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Treatment of acute ischemic stroke: intravenous and endovascular therapies

6 July 2018

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Ischemic stroke intervention requires mixed cellular protection of the penumbra

6 July 2018

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NF-kappaB signaling in cerebral ischemia

6 July 2018

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6 July 2018

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Antiproliferative activity of paeoniflorin is through cell cycle arrest and the Fas/Fas ligand-mediated apoptotic pathway in human non-small cell lung cancer A549 cells

6 July 2018

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Pro-inflammatory cytokines and their effects in the dentate gyrus

6 July 2018

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The inflammatory response in stroke

6 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3498223

Mechanisms of crosstalk between TNF-induced NF-kappaB and JNK activation in hepatocytes.

6 July 2018

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Neurovascular coupling in the normal brain and in hypertension, stroke, and Alzheimer disease

6 July 2018

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Neuroprotective effect of paeoniflorin on cerebral ischemic rat by activating adenosine A1 receptor in a manner different from its classical agonists

6 July 2018

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Obligatory role of inducible nitric oxide synthase in ischemic preconditioning

6 July 2018

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Intravenous tissue-type plasminogen activator therapy for ischemic stroke: Houston experience 1996 to 2000.

6 July 2018

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Inhibition of p38 mitogen-activated protein kinase provides neuroprotection in cerebral focal ischemia

6 July 2018

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Cyclooxygenases in the central nervous system: implications for treatment of neurological disorders

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3498223

Therapeutic potential of anti-inflammatory drugs in focal stroke

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3498223

Nitric oxide from inflammatory-activated glia synergizes with hypoxia to induce neuronal death

6 July 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0049701

Safety and feasibility of a lower dose intravenous TPA therapy for ischemic stroke beyond the first three hours

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0049701

Paeonol and paeoniflorin, the main active principles of Paeonia albiflora, protect the heart from myocardial ischemia/reperfusion injury in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0049701

Effects of paeoniflorin on the cerebral infarction, behavioral and cognitive impairments at the chronic stage of transient middle cerebral artery occlusion in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0049701

Protective effects of paeoniflorin against glutamate-induced neurotoxicity in PC12 cells via antioxidant mechanisms and Ca(2+) antagonism

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0049701

Anti-thrombosis effect of paeoniflorin: evaluated in a photochemical reaction thrombosis model in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0049701

Analgesic effect of paeoniflorin in rats with neonatal maternal separation-induced visceral hyperalgesia is mediated through adenosine A(1) receptor by inhibiting the extracellular signal-regulated protein kinase (ERK) pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0049701

Involvement of multitargets in paeoniflorin-induced preconditioning

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0049701

Paeoniflorin attenuates chronic cerebral hypoperfusion-induced learning dysfunction and brain damage in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0049701

Effects of cerebral ischemia-reperfusion on pharmacokinetic fate of paeoniflorin after intravenous administration of Paeoniae Radix extract in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0049701

Time course and sequence of pathological changes in the cerebellum of microsphere-embolized rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0049701

Changes in host blood factors and brain glia accompanying the functional recovery after systemic administration of bone marrow stem cells in ischemic stroke rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0049701

Proteasomal inhibition in intracerebral hemorrhage: neuroprotective and anti-inflammatory effects of bortezomib

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0049701

Glia-induced reversible disruption of blood-brain barrier integrity and neuropathological response of the neurovascular unit.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0049701

Mechanisms of microglia-mediated neurotoxicity in a new model of the stroke penumbra.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0049701

Genomic responses of the brain to ischemic stroke, intracerebral haemorrhage, kainate seizures, hypoglycemia, and hypoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0049701

Administration of the p38 MAPK inhibitor SB203580 affords brain protection with a wide therapeutic window against focal ischemic insult

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0049701

Inhibition of MEK/ERK 1/2 pathway reduces pro-inflammatory cytokine interleukin-1 expression in focal cerebral ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0049701

Immune status and apoptosis activation during brain death

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0049701

Acupuncture protected cerebral multi-infarction rats from memory impairment by regulating the expression of apoptosis related genes Bcl-2 and Bax in hippocampus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0049701

Stimulatory effect of paeoniflorin on adenosine A-1 receptors to increase the translocation of protein kinase C (PKC) and glucose transporter (GLUT 4) in isolated rat white adipocytes.

21 January 2018

1 reference

12 December 2020

Differential activation of MAPK/ERK and p38/SAPK in neurones and glia following focal cerebral ischaemia in the rat

1 reference

12 December 2020

Depolarizing neuromuscular blocking action induced by electropharmacological coupling in the combined effect of paeoniflorin and glycyrrhizin

1 reference

12 December 2020

Inflammatory glia mediate delayed neuronal damage after ischemia in the central nervous system

1 reference

12 December 2020

[Effects of paeoniflorin on cerebral energy metabolism, nitric oxide and nitric oxide synthase after cerebral ischemia in mongoliagerbils]

1 reference

12 December 2020

Paeoniflorin, a major constituent of peony root, reverses muscarinic M1-receptor antagonist-induced suppression of long-term potentiation in the rat hippocampal slice

1 reference

12 December 2020

10.1371/JOURNAL.PONE.0049701

Identifiers

DOI

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2 August 2017

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2 August 2017

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