(Q34488155)

2 August 2017

1 reference

title

Neurogenic neuroinflammation in fibromyalgia and complex regional pain syndrome (English)

1 reference

2 August 2017

0 references

0 references

0 references

Geoffrey Littlejohn

1

1 reference

2 August 2017

language of work or name

English

0 references

publication date

4 August 2015

1 reference

Nature Reviews Rheumatology

2 August 2017

published in

1 reference

2 August 2017

volume

11

1 reference

2 August 2017

issue

11

1 reference

2 August 2017

page(s)

639-648

1 reference

https://scigraph.springernature.com/pub.10.1038/nrrheum.2015.100

2 August 2017

exact match

0 references

cites work

A Lecture on Lumbago: Its Lessons and Analogues: Delivered at the National Hospital for the Paralysed and Epileptic.

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

History of fibromyalgia: past to present

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Inflaming the brain: CRPS a model disease to understand neuroimmune interactions in chronic pain

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Fibromyalgia: a clinical review

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Central sensitization: implications for the diagnosis and treatment of pain

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Complex regional pain syndrome in adults

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Fibromyalgia and related conditions

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Complex regional pain syndrome-significant progress in understanding

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Widespread pain in fibromyalgia is related to a deficit of endogenous pain inhibition

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Decreased central mu-opioid receptor availability in fibromyalgia.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

The science of fibromyalgia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Decreased intrinsic brain connectivity is associated with reduced clinical pain in fibromyalgia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Patients with fibromyalgia display less functional connectivity in the brain's pain inhibitory network

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Sensitization, glutamate, and the link between migraine and fibromyalgia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Elevated insular glutamate in fibromyalgia is associated with experimental pain

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Pregabalin Rectifies Aberrant Brain Chemistry, Connectivity, and Functional Response in Chronic Pain Patients

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Efficacy of memantine in the treatment of fibromyalgia: A double-blind, randomised, controlled trial with 6-month follow-up.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Sympathetic nervous system dysfunction in fibromyalgia, chronic fatigue syndrome, irritable bowel syndrome, and interstitial cystitis: a review of case-control studies

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

The hypothalamo-pituitary-adrenal axis in chronic fatigue syndrome and fibromyalgia syndrome

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Fibromyalgia and overlapping disorders: the unifying concept of central sensitivity syndromes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Clinical features and pathophysiology of complex regional pain syndrome

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Primary somatosensory cortex function in complex regional pain syndrome: a systematic review and meta-analysis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Complex regional pain syndrome: a comprehensive and critical review

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Targeting cortical representations in the treatment of chronic pain: a review

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

The specificity and mechanisms of hemilateral sensory disturbances in complex regional pain syndrome

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Which nerve fibers mediate the axon reflex flare in human skin?

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Neurogenic vasodilatation and plasma leakage in the skin

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Neurogenic Inflammation – The Peripheral Nervous System’s Role in Host Defense and Immunopathology

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Neuropeptides, neurogenic inflammation and complex regional pain syndrome (CRPS).

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

A hypothesis for the cause of complex regional pain syndrome-type I (reflex sympathetic dystrophy): pain due to deep-tissue microvascular pathology

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Rats with chronic post-ischemia pain exhibit an analgesic sensitivity profile similar to human patients with complex regional pain syndrome--type I.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Complex regional pain syndrome

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Central amplification and fibromyalgia: disorder of pain processing

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Conditioned pain modulation in populations with chronic pain: a systematic review and meta-analysis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Personality and fibromyalgia syndrome

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Complex regional pain syndrome as a stress response

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Inflammation in CRPS: role of the sympathetic supply

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

The role of life stress in fibromyalgia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Traumatic experiences, major life stressors, and self-reporting a physician-given fibromyalgia diagnosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Anxious personality is a risk factor for developing complex regional pain syndrome type I.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Lighting up the genetic understanding of fibromyalgia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Familial occurrence of complex regional pain syndrome.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Cold-induced vasospasm in patients with fibromyalgia and chronic low back pain in comparison to healthy subjects

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Symptoms of Raynaud's syndrome in patients with fibromyalgia. A study utilizing the Nielsen test, digital photoplethysmography, and measurements of platelet α2-adrenergic receptors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Immunofluorescent detection of IgG at the dermal-epidermal junction in patients with apparent primary fibrositis syndrome

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Primary fibromyalgia (fibrositis): clinical study of 50 patients with matched normal controls

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Diagnosis of fibromyalgia syndrome-a comparison of Association of the Medical Scientific Societies in Germany, survey, and American College of Rheumatology criteria.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Immunofluorescent studies of skin in primary fibrositis syndrome

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Dermal IgG deposits and increase of mast cells in patients with fibromyalgia--relevant findings or epiphenomena?

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Abnormal overexpression of mastocytes in skin biopsies of fibromyalgia patients

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Osteoprotegerin: a new biomarker for impaired bone metabolism in complex regional pain syndrome?

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Is reflex sympathetic dystrophy/complex regional pain syndrome type I a small-fiber neuropathy?

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Proposed new diagnostic criteria for complex regional pain syndrome

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Cutaneous norepinephrine application in complex regional pain syndrome

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Facilitated neurogenic inflammation in complex regional pain syndrome.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Pathological and protective roles of glia in chronic pain

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Neurogenic neuroinflammation: inflammatory CNS reactions in response to neuronal activity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

The pain of being sick: implications of immune-to-brain communication for understanding pain

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Narrative review: the pathophysiology of fibromyalgia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Immune regulation of central nervous system functions: from sickness responses to pathological pain

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Elevated CSF levels of substance P and high incidence of Raynaud phenomenon in patients with fibromyalgia: new features for diagnosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Elevated cerebrospinal fluid levels of substance P in patients with the fibromyalgia syndrome

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Increased levels of neurotrophins are not specific for chronic migraine: evidence from primary fibromyalgia syndrome

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Localization of NK1 and NK3 receptors in guinea-pig brain

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

An evolutionary stress-response hypothesis for chronic widespread pain (fibromyalgia syndrome).

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Elevated cerebrospinal fluid substance p concentrations in posttraumatic stress disorder and major depression

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Small fibre pathology in patients with fibromyalgia syndrome

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Update on laser-evoked potential findings in fibromyalgia patients in light of clinical and skin biopsy features

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Small nerve fiber involvement in patients referred for fibromyalgia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Reduction of Intraepidermal Nerve Fiber Density (IENFD) in the skin biopsies of patients with fibromyalgia: a controlled study

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Characteristic electron microscopic findings in the skin of patients with fibromyalgia--preliminary study

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Evidence of small-fiber polyneuropathy in unexplained, juvenile-onset, widespread pain syndromes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Hyperexcitable C nociceptors in fibromyalgia.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Neurologic signs and symptoms in fibromyalgia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

The important role of neuropeptides in complex regional pain syndrome

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Reflex sympathetic dystrophy of the hand: an excessive inflammatory response?

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Medical history and the onset of complex regional pain syndrome (CRPS).

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Complex regional pain syndromes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

The association between ACE inhibitors and the complex regional pain syndrome: Suggestions for a neuro-inflammatory pathogenesis of CRPS.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Differential expression patterns of cytokines in complex regional pain syndrome

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Pathologic alterations of cutaneous innervation and vasculature in affected limbs from patients with complex regional pain syndrome

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Physical therapy modalities in management of fibromyalgia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

The neuroscience and endocrinology of fibromyalgia

31 March 2020

2 references

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

31 March 2020

12 December 2020

Fibromyalgia and cytokines

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Basal inflammation and innate immune response in chronic multisite musculoskeletal pain

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Systematic review with meta-analysis: cytokines in fibromyalgia syndrome.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Evidence of central inflammation in fibromyalgia-increased cerebrospinal fluid interleukin-8 levels

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Multiplex bead array assay for detection of 25 soluble cytokines in blister fluid of patients with complex regional pain syndrome type 1.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Evidence for local inflammation in complex regional pain syndrome type 1.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Intermediate stage complex regional pain syndrome type 1 is unrelated to proinflammatory cytokines

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Mechanical hyperalgesia in complex regional pain syndrome: a role for TNF-alpha?

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Changes in cerebrospinal fluid levels of pro-inflammatory cytokines in CRPS

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Inflammation in complex regional pain syndrome: a systematic review and meta-analysis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Status of immune mediators in complex regional pain syndrome type I.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

A substance P receptor (NK1) antagonist can reverse vascular and nociceptive abnormalities in a rat model of complex regional pain syndrome type II.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Glucocorticoid inhibition of vascular abnormalities in a tibia fracture rat model of complex regional pain syndrome type I.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Activation of cutaneous immune responses in complex regional pain syndrome

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Autoimmunity against the β2 adrenergic receptor and muscarinic-2 receptor in complex regional pain syndrome

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Cervico-thoracic or lumbar sympathectomy for neuropathic pain and complex regional pain syndrome

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Regional sympathetic blockade in primary fibromyalgia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Nocturnal heart rate variability parameters as potential fibromyalgia biomarker: correlation with symptoms severity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Norepinephrine-evoked pain in fibromyalgia. A randomized pilot study [ISRCTN70707830].

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Heart rate variability in complex regional pain syndrome during rest and mental and orthostatic stress.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Increased venous alpha-adrenoceptor responsiveness in patients with reflex sympathetic dystrophy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Sympathetic nervous system influence on the innate immune response.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Involvement of the sympathetic nervous system in complex regional pain syndrome

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Does psychological stress cause chronic pain?

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Adrenergic dysregulation and pain with and without acute beta-blockade in women with fibromyalgia and temporomandibular disorder

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Interventions for treating pain and disability in adults with complex regional pain syndrome- an overview of systematic reviews

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Fibromyalgia: disease synopsis, medication cost effectiveness and economic burden

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

NK1 (substance P) receptor antagonists--why are they not analgesic in humans?

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Immunoglobulin g for the treatment of chronic pain: report of an expert workshop

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Effect of immunomodulating medications in complex regional pain syndrome: a systematic review.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Non-stereoselective reversal of neuropathic pain by naloxone and naltrexone: involvement of toll-like receptor 4 (TLR4)

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

The use of low-dose naltrexone (LDN) as a novel anti-inflammatory treatment for chronic pain

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Ibudilast: a review of its pharmacology, efficacy and safety in respiratory and neurological disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

A chronic fatigue syndrome model demonstrates mechanical allodynia and muscular hyperalgesia via spinal microglial activation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Efficacy and safety of ketamine in patients with complex regional pain syndrome: a systematic review.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Emerging therapies for fibromyalgia: an update

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

Memantine Treatment of Complex Regional Pain Syndrome

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.100

The effect of capsaicin on some experimental inflammations in human skin

31 March 2020

1 reference

12 December 2020

Increased concentrations of nerve growth factor in cerebrospinal fluid of patients with fibromyalgia

1 reference

12 December 2020

Phenoxybenzamine in complex regional pain syndrome: potential role and novel mechanisms

1 reference

12 December 2020

A prospective evaluation of 118 patients with the fibromyalgia syndrome: prevalence of Raynaud's phenomenon, sicca symptoms, ANA, low complement, and Ig deposition at the dermal-epidermal junction

1 reference

12 December 2020

Stress modulates key psychological processes and characteristic symptoms in females with fibromyalgia

1 reference

12 December 2020

Functional imaging of pain in patients with primary fibromyalgia

1 reference

12 December 2020

Effects of selective slow wave sleep disruption on musculoskeletal pain and fatigue in middle aged women.

1 reference

12 December 2020

A controlled and blinded study of immunoreactant deposition at the dermal-epidermal junction of patients with primary fibrositis syndrome

1 reference

12 December 2020

Increased neurogenic inflammation in fibrositis syndrome

1 reference

12 December 2020

Modulation of pain in fibromyalgia (fibrositis syndrome): cerebrospinal fluid (CSF) investigation of pain related neuropeptides with special reference to calcitonin gene related peptide (CGRP)

1 reference

12 December 2020

Attachment of IgG to dermal extracellular matrix in patients with fibromyalgia.

1 reference

12 December 2020

Is there a role for cytokine based therapies in fibromyalgia

1 reference

12 December 2020

Evaluation of vascular injury with proinflammatory cytokines, thrombomodulin and fibronectin in patients with primary fibromyalgia

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRRHEUM.2015.100

1 reference

Dimensions Publication ID

2 August 2017

1030378167

0 references

1 reference