(Q34489708)

2 August 2017

title

Antifibrotic effects of roscovitine in normal and scleroderma fibroblasts (English)

1 reference

2 August 2017

Richard A Steinman

1

1 reference

2 August 2017

Andria Rasile Robinson

series ordinal

2

1 reference

2 August 2017

Carol A Feghali-Bostwick

series ordinal

3

1 reference

2 August 2017

language of work or name

English

0 references

publication date

20 November 2012

1 reference

2 August 2017

1 reference

2 August 2017

volume

7

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2 August 2017

issue

11

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2 August 2017

page(s)

e48560

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Creative Commons Attribution 4.0 International

2 August 2017

copyright license

start time

20 November 2012

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

describes a project that uses

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3502367/fullTextXML

inferred from PubMed Central ID database lookup

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Roscovitine and other purines as kinase inhibitors. From starfish oocytes to clinical trials

6 July 2018

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Inhibition of the Jak/STAT signaling pathway prevents the high glucose-induced increase in tgf-beta and fibronectin synthesis in mesangial cells.

6 July 2018

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Activation of fibroblast procollagen alpha 1(I) transcription by mechanical strain is transforming growth factor-beta-dependent and involves increased binding of CCAAT-binding factor (CBF/NF-Y) at the proximal promoter

6 July 2018

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6 July 2018

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Cdk5 is involved in neuregulin-induced AChR expression at the neuromuscular junction

6 July 2018

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6 July 2018

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Regulation of type I collagen genes expression

6 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3502367

6 July 2018

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Smad-dependent stimulation of type I collagen gene expression in human skin fibroblasts by TGF-beta involves functional cooperation with p300/CBP transcriptional coactivators

21 January 2018

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Density-dependent growth inhibition of fibroblasts ectopically expressing p27(kip1)

6 July 2018

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Regulation of E2F transcription by cyclin E-Cdk2 kinase mediated through p300/CBP co-activators

6 July 2018

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Role and interaction of connective tissue growth factor with transforming growth factor-beta in persistent fibrosis: A mouse fibrosis model

6 July 2018

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Endogenous IL-1alpha from systemic sclerosis fibroblasts induces IL-6 and PDGF-A.

6 July 2018

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Transcriptional control by cell-cycle regulators: a review

6 July 2018

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The cyclin-dependent kinase inhibitors olomoucine and roscovitine arrest human fibroblasts in G1 phase by specific inhibition of CDK2 kinase activity

6 July 2018

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Induction of subcutaneous tissue fibrosis in newborn mice by transforming growth factor beta--simultaneous application with basic fibroblast growth factor causes persistent fibrosis

6 July 2018

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Reduction in fibronectin expression and alteration in cell morphology are coincident in NIH3T3 cells expressing a mutant E2F1 transcription factor.

6 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3502367

Direct in vivo inhibition of the nuclear cell cycle cascade in experimental mesangial proliferative glomerulonephritis with Roscovitine, a novel cyclin-dependent kinase antagonist

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3502367

Cyclin-dependent kinase activation and S-phase induction of the cyclin B1 gene are linked through the CCAAT elements

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3502367

Regulation of the human alpha 2(1) procollagen gene by sequences adjacent to the CCAAT box

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3502367

A novel transforming growth factor beta response element controls the expression of the connective tissue growth factor gene

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3502367

Inhibition of cyclin-dependent kinases by purine analogues: crystal structure of human cdk2 complexed with roscovitine

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3502367

LAP (NF-IL6) transactivates the collagen alpha 1(I) gene from a 5' regulatory region

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3502367

Induction of an acute phase response in rats stimulates the expression of alpha 1(I) procollagen messenger ribonucleic acid in their livers. Possible role of interleukin-6.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3502367

Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5.

6 July 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0048560

Seliciclib in malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0048560

A novel CDK inhibitor, CYC202 (R-roscovitine), overcomes the defect in p53-dependent apoptosis in B-CLL by down-regulation of genes involved in transcription regulation and survival.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0048560

Stat3 contributes to keloid pathogenesis via promoting collagen production, cell proliferation and migration.

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0048560

A rough guide to a smooth brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0048560

Activation of Stat3 by cell confluence reveals negative regulation of Stat3 by cdk2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0048560

The cell cycle inhibitor p21 controls T-cell proliferation and sex-linked lupus development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0048560

Phase I evaluation of seliciclib (R-roscovitine), a novel oral cyclin-dependent kinase inhibitor, in patients with advanced malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0048560

Regulation of thymidine kinase expression during cellular senescence

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3502367

Serum levels of interleukin-6 and interleukin-10 correlate with total skin thickness score in patients with systemic sclerosis

27 October 2018

1 reference

12 December 2020

Transcription and expression of transforming growth factor type beta in the skin of progressive systemic sclerosis: a mediator of fibrosis?

1 reference

12 December 2020

Mechanisms of pathogenesis in scleroderma. I. Overproduction of interleukin 6 by fibroblasts cultured from affected skin sites of patients with scleroderma

1 reference

12 December 2020

Control of IL-6 expression and response in fibroblasts from patients with systemic sclerosis

1 reference

12 December 2020

Transduction of full-length TAT fusion proteins into mammalian cells: TAT-p27Kip1 induces cell migration

1 reference

12 December 2020

Anti-sclerotic effect of transforming growth factor-beta antibody in a mouse model of bleomycin-induced scleroderma

1 reference

12 December 2020

NF-Y-mediated trans-activation of the human thymidine kinase promoter is closely linked to activation of cyclin-dependent kinase

1 reference

12 December 2020

R-roscovitine (CYC202) alleviates renal cell proliferation in nephritis without aggravating podocyte injury

1 reference

12 December 2020

Functional implications of the IL-6 signaling pathway in keloid pathogenesis

1 reference

12 December 2020

Recombinant human anti–transforming growth factor β1 antibody therapy in systemic sclerosis: A multicenter, randomized, placebo-controlled phase I/II trial of CAT-192

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12 December 2020

Stable expression of a dominant negative mutant of CCAAT binding factor/NF-Y in mouse fibroblast cells resulting in retardation of cell growth and inhibition of transcription of various cellular genes

1 reference

12 December 2020

10.1371/JOURNAL.PONE.0048560

Identifiers

DOI

1 reference

2 August 2017

0 references

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2 August 2017

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