(Q34492738)

English

Immunization of aged mice with a pneumococcal conjugate vaccine combined with an unmethylated CpG-containing oligodeoxynucleotide restores defective immunoglobulin G antipolysaccharide responses and specific CD4+-T-cell priming to young adult levels

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scholarly article

1 reference

Europe PubMed Central

2 August 2017

Immunization of aged mice with a pneumococcal conjugate vaccine combined with an unmethylated CpG-containing oligodeoxynucleotide restores defective immunoglobulin G antipolysaccharide responses and specific CD4+-T-cell priming to young adult levels (English)

1 reference

Europe PubMed Central

2 August 2017

0 references

0 references

pneumococcal conjugate vaccine

1 reference

based on heuristic

inferred from title

author name string

Goutam Sen

1

1 reference

Europe PubMed Central

2 August 2017

Quanyi Chen

2

1 reference

Europe PubMed Central

2 August 2017

Clifford M Snapper

3

1 reference

Europe PubMed Central

2 August 2017

language of work or name

0 references

publication date

1 April 2006

1 reference

Europe PubMed Central

2 August 2017

Infection and Immunity

1 reference

Europe PubMed Central

2 August 2017

74

1 reference

Europe PubMed Central

2 August 2017

2177-2186

1 reference

Europe PubMed Central

2 August 2017

4

1 reference

Europe PubMed Central

2 August 2017

CHEMO-IMMUNOLOGICAL STUDIES ON CONJUGATED CARBOHYDRATE-PROTEINS : V. THE IMMUNOLOGICAL SPECIFITY OF AN ANTIGEN PREPARED BY COMBINING THE CAPSULAR POLYSACCHARIDE OF TYPE III PNEUMOCOCCUS WITH FOREIGN PROTEIN.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1418916

6 July 2018

The critical DNA flanking sequences of a CpG oligodeoxynucleotide, but not the 6 base CpG motif, can be replaced with RNA without quantitative or qualitative changes in Toll-like receptor 9-mediated activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1418916

6 July 2018

The effect of age on the cognate function of CD4+ T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1418916

6 July 2018

Immunosenescence and macrophage functional plasticity: dysregulation of macrophage function by age-associated microenvironmental changes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1418916

6 July 2018

B cells and aging: gauging the interplay of generative, selective, and homeostatic events

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1418916

6 July 2018

B cells, E2A, and aging

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1418916

6 July 2018

Both innate immunity and type 1 humoral immunity to Streptococcus pneumoniae are mediated by MyD88 but differ in their relative levels of dependence on toll-like receptor 2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1418916

6 July 2018

Age-related defects in CD4 T cell cognate helper function lead to reductions in humoral responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1418916

6 July 2018

Pneumococcal vaccine development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1418916

6 July 2018

Pneumococcal vaccination for the elderly in The Netherlands? Assessment of the quality and content of available comparative studies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1418916

6 July 2018

Inflammatory cytokines overcome age-related defects in CD4 T cell responses in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1418916

6 July 2018

Review of pneumococcal conjugate vaccine in adults: implications on clinical development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1418916

6 July 2018

Aging and innate immune cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1418916

6 July 2018

Haemophilus influenzae type b-outer membrane protein complex glycoconjugate vaccine induces cytokine production by engaging human toll-like receptor 2 (TLR2) and requires the presence of TLR2 for optimal immunogenicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1418916

6 July 2018

Effectiveness of pneumococcal polysaccharide vaccine in older adults

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1418916

6 July 2018

Endogenous pro- and anti-inflammatory cytokines differentially regulate an in vivo humoral response to Streptococcus pneumoniae.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1418916

6 July 2018

Regulatory role of T cells producing both interferon gamma and interleukin 10 in persistent infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1418916

6 July 2018

Adjuvant effects of CpG oligodeoxynucleotides on responses against T-independent type 2 antigens

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1418916

6 July 2018

A Toll-like receptor recognizes bacterial DNA

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1418916

6 July 2018

Review article: ageing and the neutrophil: no appetite for killing?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1418916

6 July 2018

Efficacy, safety and immunogenicity of heptavalent pneumococcal conjugate vaccine in children. Northern California Kaiser Permanente Vaccine Study Center Group

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1418916

6 July 2018

Diseases of aging

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1418916

6 July 2018

CpG oligodeoxynucleotides act as adjuvants for pneumococcal polysaccharide-protein conjugate vaccines and enhance antipolysaccharide immunoglobulin G2a (IgG2a) and IgG3 antibodies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1418916

6 July 2018

Cognate stimulatory B-cell-T-cell interactions are critical for T-cell help recruited by glycoconjugate vaccines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1418916

6 July 2018

Immunologic memory induced by a glycoconjugate vaccine in a murine adoptive lymphocyte transfer model.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1418916

6 July 2018

Age-related changes in antibody repertoire: contribution from T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1418916

6 July 2018

Lifetime of plasma cells in the bone marrow.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1418916

6 July 2018

Th1/Th2 changes in aging

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1418916

6 July 2018

The physiology of germinal centers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1418916

6 July 2018

A model for induction of T cell-independent humoral immunity in response to polysaccharide antigens.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1418916

6 July 2018

The aging immune system: primer and prospectus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1418916

6 July 2018

Relative contribution of T and B cells to hypermutation and selection of the antibody repertoire in germinal centers of aged mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1418916

6 July 2018

Specific humoral immunity in the elderly: in vivo and in vitro response to vaccination.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1418916

6 July 2018

Streptococcus pneumoniae polysaccharide vaccine: age and dose responses, safety, persistence of antibody, revaccination, and simultaneous administration of pneumococcal and influenza vaccines.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1418916

6 July 2018

Evidence implicating L3T4 in class II MHC antigen reactivity; monoclonal antibody GK1.5 (anti-L3T4a) blocks class II MHC antigen-specific proliferation, release of lymphokines, and binding by cloned murine helper T lymphocyte lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1418916

6 July 2018

Maturation of the humoral immune response in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1418916

6 July 2018

A selective increase in the generation of phosphorylcholine-specific B cells associated with aging

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1418916

6 July 2018

Polysaccharide-protein conjugates: a new generation of vaccines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1418916

6 July 2018

Immune responses of systemic and mucosal lymphoid organs to Pnu-Imune vaccine as a function of age and the efficacy of monophosphoryl lipid A as an adjuvant.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1418916

6 July 2018

Failure to respond to influenza vaccine in the aged: correlation with B-cell number and function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1418916

6 July 2018

Immune function in aged mice. II. B-cell function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1418916

6 July 2018

The effects of age on the immune response to type III pneumococcal polysaccharide (SIII) and bacterial lipopolysaccharide (LPS) in BALB/c, SJL/J, and C3H mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1418916

6 July 2018

In vivo humoral immune responses to isolated pneumococcal polysaccharides are dependent on the presence of associated TLR ligands

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1418916

27 October 2018

Age effects on macrophage function vary by tissue site, nature of stimulant, and exercise behavior.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1418916

27 October 2018

Differential regulation of IgG anti-capsular polysaccharide and antiprotein responses to intact Streptococcus pneumoniae in the presence of cognate CD4+ T cell help

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1418916

27 October 2018

CpG DNA functions as an effective adjuvant for the induction of immune responses in aged mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1418916

27 October 2018

Influenza and pneumococcal vaccination levels among persons aged > or = 65 years--United States, 1999.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1418916

27 October 2018

CpG DNA induces maturation of dendritic cells with distinct effects on nascent and recycling MHC-II antigen-processing mechanisms.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1418916

27 October 2018

B7 requirements for primary and secondary protein- and polysaccharide-specific Ig isotype responses to Streptococcus pneumoniae.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1418916

27 October 2018

In vivo polysaccharide-specific IgG isotype responses to intact Streptococcus pneumoniae are T cell dependent and require CD40- and B7-ligand interactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1418916

27 October 2018

Immunosenescence and germinal center reaction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1418916

27 October 2018

Impact of Pneumococcal Vaccination on Morbidity and Mortality of Geriatric Patients: A Case-Controlled Study

1 reference

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9 December 2018

Alterations in the human immune response to the hepatitis B vaccine among the elderly

1 reference

https://pubmed.ncbi.nlm.nih.gov/16552048

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The antibody responses to pneumococcal capsular polysaccharides in aged individuals

1 reference

https://pubmed.ncbi.nlm.nih.gov/16552048

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pneumococcal vaccine in elderly patients with COPD

1 reference

https://pubmed.ncbi.nlm.nih.gov/16552048

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lack of age-associated immune dysfunction in mucosal-associated lymph nodes

1 reference

https://pubmed.ncbi.nlm.nih.gov/16552048

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Natural and vaccine-related immunity to Streptococcus pneumoniae

1 reference

https://pubmed.ncbi.nlm.nih.gov/16552048

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Incremental effectiveness of pneumococcal vaccine on simultaneously administered influenza vaccine in preventing pneumonia and pneumococcal pneumonia among persons aged 65 years or older

1 reference

https://pubmed.ncbi.nlm.nih.gov/16552048

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The health and economic benefits associated with pneumococcal vaccination of elderly persons with chronic lung disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16552048

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dysregulation of IL-10 production with aging: possible linkage to the age-associated decline in DHEA and its sulfated derivative

1 reference

https://pubmed.ncbi.nlm.nih.gov/16552048

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phenotypic and functional characteristics of circulating monocytes of elderly persons

1 reference

https://pubmed.ncbi.nlm.nih.gov/16552048

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The unresponsiveness of aged mice to polysaccharide antigens is a result of a defect in macrophage function

1 reference

https://pubmed.ncbi.nlm.nih.gov/16552048

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-10 enhances immune responses to pneumococcal polysaccharides and sheep erythrocytes in young and aged mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/16552048

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immune response to a 14-valent pneumococcal polysaccharide vaccine in the elderly

1 reference

https://pubmed.ncbi.nlm.nih.gov/16552048

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pneumococcal polysaccharide vaccines do not protect the elderly from pneumococcal infections

1 reference

https://pubmed.ncbi.nlm.nih.gov/16552048

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CpG-DNA stimulates cellular and humoral immunity and promotes Th1 differentiation in aged BALB/c mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/16552048

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/IAI.74.4.2177-2186.2006

1 reference

Europe PubMed Central

2 August 2017

1 reference

Europe PubMed Central

2 August 2017

1 reference

Europe PubMed Central

2 August 2017

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