(Q34507042)

2 August 2017

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title

Drosophila innate immunity: an evolutionary perspective (English)

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2 August 2017

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Jules A Hoffmann

1

1 reference

PubMed ID

11812988

2 August 2017

Jean-Marc Reichhart

series ordinal

2

1 reference

PubMed ID

11812988

2 August 2017

language of work or name

English

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publication date

1 February 2002

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2 August 2017

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2 August 2017

3

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2 August 2017

121-126

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2 August 2017

2

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Approaching the asymptote? Evolution and revolution in immunology

2 August 2017

1 reference

https://api.crossref.org/works/10.1038%2FNI0202-121

Innate immunity: the virtues of a nonclonal system of recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0202-121

Mechanism of the binding, insertion and destabilization of phospholipid bilayer membranes by alpha-helical antimicrobial and cell non-selective membrane-lytic peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0202-121

Antimicrobial peptides in mammalian and insect host defence

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0202-121

The instructive role of innate immunity in the acquired immune response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0202-121

A drosomycin-GFP reporter transgene reveals a local immune response in Drosophila that is not dependent on the Toll pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0202-121

Tissue-specific inducible expression of antimicrobial peptide genes in Drosophila surface epithelia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0202-121

The imd gene is required for local Cecropin expression in Drosophila barrier epithelia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0202-121

Postembryonic hematopoiesis in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0202-121

Antimicrobial peptides in insects; structure and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0202-121

Role of the integument in insect defense: pro-phenol oxidase cascade in the cuticular matrix

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0202-121

Constitutive expression of a complement-like protein in toll and JAK gain-of-function mutants of Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0202-121

Conserved role of a complement-like protein in phagocytosis revealed by dsRNA knockout in cultured cells of the mosquito, Anopheles gambiae.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0202-121

Specification of Drosophila hematopoietic lineage by conserved transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0202-121

kappa B-like motifs regulate the induction of immune genes in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0202-121

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0202-121

Phylogenetic perspectives in innate immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0202-121

Induction and regulation of antimicrobial peptides in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0202-121

A conserved signaling pathway: the Drosophila toll-dorsal pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0202-121

The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0202-121

A recessive mutation, immune deficiency (imd), defines two distinct control pathways in the Drosophila host defense

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0202-121

The Toll gene of Drosophila, required for dorsal-ventral embryonic polarity, appears to encode a transmembrane protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0202-121

Genetic and molecular characterization of tube, a Drosophila gene maternally required for embryonic dorsoventral polarity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0202-121

cactus, a gene involved in dorsoventral pattern formation of Drosophila, is related to the I kappa B gene family of vertebrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0202-121

Characterization of the Drosophila cactus locus and analysis of interactions between cactus and dorsal proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0202-121

pelle encodes a protein kinase required to establish dorsoventral polarity in the Drosophila embryo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0202-121

The spätzle gene encodes a component of the extracellular signaling pathway establishing the dorsal-ventral pattern of the Drosophila embryo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0202-121

Drosophila MyD88 is an adapter in the Toll signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0202-121

Drosophila MyD88 is required for the response to fungal and Gram-positive bacterial infections

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0202-121

Three-dimensional structure of a complex between the death domains of Pelle and Tube

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0202-121

A dorso-ventral shift of embryonic primordia in a new maternal-effect mutant of Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0202-121

Dorsal, an embryonic polarity gene in Drosophila, is homologous to the vertebrate proto-oncogene, c-rel.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0202-121

Dif, a dorsal-related gene that mediates an immune response in Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0202-121

Origins of immunity: Relish, a compound Rel-like gene in the antibacterial defense of Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0202-121

A mosaic analysis in Drosophila fat body cells of the control of antimicrobial peptide genes by the Rel proteins Dorsal and DIF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0202-121

Toll receptor-mediated Drosophila immune response requires Dif, an NF-kappaB factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0202-121

The Rel protein DIF mediates the antifungal but not the antibacterial host defense in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0202-121

Specificity of Rel-inhibitor interactions in Drosophila embryos

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0202-121

Genome-wide analysis of the Drosophila immune response by using oligonucleotide microarrays

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0202-121

A genome-wide analysis of immune responses in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0202-121

Getting knotted: a model for the structure and activation of Spätzle.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0202-121

Signal transduction by a protease cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0202-121

Constitutive activation of toll-mediated antifungal defense in serpin-deficient Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0202-121

Drosophila Toll is activated by Gram-positive bacteria through a circulating peptidoglycan recognition protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0202-121

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0202-121

The Drosophila toll gene functions zygotically and is necessary for proper motoneuron and muscle development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0202-121

Activation of the Drosophila NF-kappaB factor Relish by rapid endoproteolytic cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0202-121

Role of Drosophila IKK gamma in a toll-independent antibacterial immune response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0202-121

The antibacterial arm of the drosophila innate immune response requires an IkappaB kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0202-121

A Drosophila IkappaB kinase complex required for Relish cleavage and antibacterial immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0202-121

Drosophila immune deficiency (IMD) is a death domain protein that activates antibacterial defense and can promote apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0202-121

Interactions between the cellular and humoral immune responses in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0202-121

The Drosophila caspase Dredd is required to resist gram-negative bacterial infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0202-121

Mutations in the Drosophila dTAK1 gene reveal a conserved function for MAPKKKs in the control of rel/NF-kappaB-dependent innate immune responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0202-121

Drosophila host defense: differential induction of antimicrobial peptide genes after infection by various classes of microorganisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0202-121

Interaction and specificity of Rel-related proteins in regulating Drosophila immunity gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0202-121

Role of the integument in insect immunity: epicuticular abrasion and induction of cecropin synthesis in cuticular epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0202-121

Independent evolution of Toll and related genes in insects and mammals

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0202-121

Oyster IKK-like protein shares structural and functional properties with its mammalian homologues.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0202-121

Molecular cloning and characterization of SRAM, a novel insect rel/ankyrin-family protein present in nuclei

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0202-121

Toll-like receptors in the induction of the innate immune response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0202-121

Innate immune recognition: mechanisms and pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0202-121

Toll-like receptors: critical proteins linking innate and acquired immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0202-121

Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0202-121

The evolution and genetics of innate immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0202-121

NF-kappaB signaling pathways in mammalian and insect innate immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0202-121

The TNF and TNF receptor superfamilies: integrating mammalian biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0202-121

Toll-like receptors control activation of adaptive immune responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0202-121

7 January 2021

Horseshoe crab coagulogen is an invertebrate protein with a nerve growth factor-like domain

1 reference

https://api.crossref.org/works/10.1038%2FNI0202-121

7 January 2021

The Drosophila membrane receptor Toll can function to promote cellular adhesion.

1 reference

https://api.crossref.org/works/10.1038%2FNI0202-121

7 January 2021

Immune factor Gambif1, a new rel family member from the human malaria vector, Anopheles gambiae

1 reference

https://api.crossref.org/works/10.1038%2FNI0202-121

7 January 2021

Identifiers

DOI

10.1038/NI0202-121

1 reference

2 August 2017

1 reference

PubMed ID

11812988