(Q34513500)

2 August 2017

An mGluR2/3 antagonist, MGS0039, exerts antidepressant and anxiolytic effects in behavioral models in rats (English)

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2 August 2017

Takao Yoshimizu

1

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2 August 2017

Toshiharu Shimazaki

series ordinal

2

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2 August 2017

Akie Ito

series ordinal

3

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2 August 2017

Shigeyuki Chaki

series ordinal

4

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2 August 2017

13 April 2006

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2 August 2017

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2 August 2017

186

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2 August 2017

4

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2 August 2017

587-593

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https://scigraph.springernature.com/pub.10.1007/s00213-006-0390-7

2 August 2017

0 references

cites work

Synthesis, in vitro pharmacology, structure-activity relationships, and pharmacokinetics of 3-alkoxy-2-amino-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivatives as potent and selective group II metabotropic glutamate receptor antagonists

1 reference

12 December 2020

The metabotropic glutamate 2/3 receptor agonists LY354740 and LY379268 selectively attenuate phencyclidine versus d-amphetamine motor behaviors in rats

1 reference

12 December 2020

Serotonergic activation reduces defensive freezing in the conditioned fear paradigm.

1 reference

12 December 2020

Imipramine and fluoxetine prevent the stress-induced escape deficits in rats through a distinct mechanism of action.

1 reference

12 December 2020

Double dissociation between the involvement of the bed nucleus of the stria terminalis and the central nucleus of the amygdala in startle increases produced by conditioned versus unconditioned fear.

1 reference

12 December 2020

Reversal of phencyclidine effects by a group II metabotropic glutamate receptor agonist in rats

1 reference

12 December 2020

Activation of glutamatergic neurotransmission by ketamine: a novel step in the pathway from NMDA receptor blockade to dopaminergic and cognitive disruptions associated with the prefrontal cortex.

1 reference

12 December 2020

Neuropharmacological profiles of antagonists of group II metabotropic glutamate receptors

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12 December 2020

Blocking of acquisition but not expression of conditioned fear-potentiated startle by NMDA antagonists in the amygdala

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12 December 2020

Metabotropic glutamate II receptor agonists in panic disorder: a double blind clinical trial with LY354740.

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12 December 2020

MGS0039: a potent and selective group II metabotropic glutamate receptor antagonist with antidepressant-like activity.

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12 December 2020

Increased cell proliferation in the adult mouse hippocampus following chronic administration of group II metabotropic glutamate receptor antagonist, MGS0039.

1 reference

12 December 2020

A metabotropic glutamate 2/3 receptor antagonist, MGS0039, increases extracellular dopamine levels in the nucleus accumbens shell.

1 reference

12 December 2020

Cell proliferation in adult hippocampus is decreased by inescapable stress: reversal by fluoxetine treatment

1 reference

12 December 2020

Learned helplessness as a model of depression. Comment and integration

1 reference

12 December 2020

Effects of conditioned fear stress on serotonin neurotransmission and freezing behavior in rats

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12 December 2020

Intra-amygdala infusion of the N-methyl-D-aspartate receptor antagonist AP5 blocks acquisition but not expression of fear-potentiated startle to an auditory conditioned stimulus

1 reference

12 December 2020

Reversal of helpless behavior by serotonin uptake blockers in rats.

1 reference

12 December 2020

Learned helplessness in the rat

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12 December 2020

Additivity of neurochemical changes in learned helplessness and imipramine

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12 December 2020

Altered transcript expression of NMDA receptor-associated postsynaptic proteins in the thalamus of subjects with schizophrenia

1 reference

12 December 2020

On the role of prefrontal cortex glutamate for the antithetical phenomenology of obsessive compulsive disorder and attention deficit hyperactivity disorder

1 reference

12 December 2020

Selective action of (-)-2-oxa-4-aminobicyclo[3.1.0]hexane-4,6-dicarboxylate (LY379268), a group II metabotropic glutamate receptor agonist, on basal and phencyclidine-induced dopamine release in the nucleus accumbens shell

1 reference

12 December 2020

Prevention of learned helplessness: in vivo correlation with cortical serotonin

1 reference

12 December 2020

Antagonism of endogenous CRH systems attenuates stress-induced freezing behavior in rats

1 reference

12 December 2020

Inhibition of cAMP response element-binding protein or dynorphin in the nucleus accumbens produces an antidepressant-like effect.

1 reference

12 December 2020

Learned helplessness induction decreases in vivo cortical serotonin release.

1 reference

12 December 2020

Infusion of the non-NMDA receptor antagonist CNQX into the amygdala blocks the expression of fear-potentiated startle.

1 reference

12 December 2020

Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants

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12 December 2020

Long-term behavioral and neurochemical effects of chronic stress exposure in rats

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12 December 2020

Conditioned and unconditional components of post-shock freezing.

1 reference

12 December 2020

Effects of a metabotropic glutamate(2/3) receptor agonist (LY544344/LY354740) on panic anxiety induced by cholecystokinin tetrapeptide in healthy humans: preliminary results

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12 December 2020

Conditional analgesia, defensive freezing, and benzodiazepines

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12 December 2020

Decrease in caudate glutamatergic concentrations in pediatric obsessive-compulsive disorder patients taking paroxetine

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12 December 2020

Striatal excitatory amino acid transporter transcript expression in schizophrenia, bipolar disorder, and major depressive disorder

1 reference

12 December 2020

AMPA receptor stimulation mediates the antidepressant-like effect of a group II metabotropic glutamate receptor antagonist

1 reference

12 December 2020

Anxiolytic effects of a novel group II metabotropic glutamate receptor agonist (LY354740) in the fear-potentiated startle paradigm in humans

1 reference

12 December 2020

Effects of ipsapirone and BAY R 1531 on learned helplessness.

1 reference

12 December 2020

Pharmacology and functions of metabotropic glutamate receptors

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12 December 2020

Anxiolytic and side-effect profile of LY354740: a potent, highly selective, orally active agonist for group II metabotropic glutamate receptors.

1 reference

12 December 2020

The role of amygdala glutamate receptors in fear learning, fear-potentiated startle, and extinction

1 reference

12 December 2020

Specificity of the learned helplessness model of depression.

1 reference

12 December 2020

Serotonin reuptake inhibitors reduce conditioned fear stress-induced freezing behavior in rats.

1 reference

12 December 2020

LY354740, an mGlu2/3 receptor agonist as a novel approach to treat anxiety/stress

1 reference

12 December 2020

Anxiolytic-like activity of MGS0039, a potent group II metabotropic glutamate receptor antagonist, in a marble-burying behavior test

1 reference

12 December 2020

Selective serotonin reuptake inhibitor reduces conditioned fear through its effect in the amygdala

1 reference

12 December 2020

10.1007/S00213-006-0390-7

Identifiers

DOI

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Dimensions Publication ID

2 August 2017

0 references

1 reference