(Q34517448)

2 August 2017

title

A potent anti-HB-EGF monoclonal antibody inhibits cancer cell proliferation and multiple angiogenic activities of HB-EGF (English)

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2 August 2017

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Shuji Sato

1

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2 August 2017

Andrew W Drake

series ordinal

2

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2 August 2017

Isamu Tsuji

series ordinal

3

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2 August 2017

Jinhong Fan

series ordinal

4

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2 August 2017

language of work or name

English

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publication date

14 December 2012

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2 August 2017

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2 August 2017

volume

7

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2 August 2017

issue

12

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2 August 2017

page(s)

e51964

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Creative Commons Attribution 4.0 International

2 August 2017

copyright license

start time

14 December 2012

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April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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Anti-human HB-EGF monoclonal antibodies inhibiting ectodomain shedding of HB-EGF and diphtheria toxin binding

7 July 2018

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The complete family of epidermal growth factor receptors and their ligands are co-ordinately expressed in breast cancer.

7 July 2018

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A three-gene signature for outcome in soft tissue sarcoma

7 July 2018

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7 July 2018

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The significance of disulfide bonding in biological activity of HB-EGF, a mutagenesis approach

7 July 2018

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Validation of HB-EGF and amphiregulin as targets for human cancer therapy.

7 July 2018

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The carboxyl-terminal fragment of pro-HB-EGF reverses Bcl6-mediated gene repression.

7 July 2018

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Gastrin-releasing peptide receptor mediates activation of the epidermal growth factor receptor in lung cancer cells

7 July 2018

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Heparin-binding EGF-like growth factor accelerates keratinocyte migration and skin wound healing

7 July 2018

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7 July 2018

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Heparin-binding EGF-like growth factor is a promising target for ovarian cancer therapy.

7 July 2018

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CRM197 (nontoxic diphtheria toxin): effects on advanced cancer patients

7 July 2018

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Proteolytic release of the carboxy-terminal fragment of proHB-EGF causes nuclear export of PLZF

7 July 2018

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Defective valvulogenesis in HB-EGF and TACE-null mice is associated with aberrant BMP signaling

7 July 2018

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Heparin-binding EGF-like growth factor and ErbB signaling is essential for heart function

7 July 2018

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7 July 2018

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7 July 2018

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Inhibition of heparin-binding epidermal growth factor-like growth factor increases albuminuria in puromycin aminonucleoside nephrosis

7 July 2018

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Increased expression of heparin binding EGF (HB-EGF), amphiregulin, TGF alpha and epiregulin in androgen-independent prostate cancer cell lines

7 July 2018

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Heparin-binding epidermal growth factor-like growth factor, a v-Jun target gene, induces oncogenic transformation

7 July 2018

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Heparin-binding epidermal growth factor-like growth factor stimulates mitogenic signaling and is highly expressed in human malignant gliomas

7 July 2018

1 reference

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EGF, TGF alpha, AR and HB-EGF are autocrine growth factors for human bladder carcinoma cell lines

7 July 2018

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Binding interaction of the heregulinbeta egf domain with ErbB3 and ErbB4 receptors assessed by alanine scanning mutagenesis

7 July 2018

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Activation of HER4 by heparin-binding EGF-like growth factor stimulates chemotaxis but not proliferation

7 July 2018

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Mouse preimplantation blastocysts adhere to cells expressing the transmembrane form of heparin-binding EGF-like growth factor.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3522611

Co-expression of heparin-binding EGF-like growth factor and related peptides in human gastric carcinoma

7 July 2018

1 reference

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The functional importance of hydrophobicity of the tyrosine at position 13 of human epidermal growth factor in receptor binding.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3522611

Eosinophils expressing heparin-binding EGF-like growth factor mRNA localize around lung microvessels in pulmonary hypertension

7 July 2018

1 reference

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Induction and expression of heparin-binding EGF-like growth factor in human pancreatic cancer

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3522611

Heparin-binding EGF-like growth factor gene is induced in the mouse uterus temporally by the blastocyst solely at the site of its apposition: a possible ligand for interaction with blastocyst EGF-receptor in implantation.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3522611

The membrane protein CD9/DRAP 27 potentiates the juxtacrine growth factor activity of the membrane-anchored heparin-binding EGF-like growth factor

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3522611

Diphtheria toxin binds to the epidermal growth factor (EGF)-like domain of human heparin-binding EGF-like growth factor/diphtheria toxin receptor and inhibits specifically its mitogenic activity.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3522611

Localization of heparin-binding EGF-like growth factor in the smooth muscle cells and macrophages of human atherosclerotic plaques

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3522611

T lymphocytes that infiltrate tumors and atherosclerotic plaques produce heparin-binding epidermal growth factor-like growth factor and basic fibroblast growth factor: a potential pathologic role

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3522611

Phorbol ester induces the rapid processing of cell surface heparin-binding EGF-like growth factor: conversion from juxtacrine to paracrine growth factor activity

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3522611

A heparin sulfate-regulated human keratinocyte autocrine factor is similar or identical to amphiregulin

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3522611

A Heparin-Binding Growth Factor Secreted by Macrophage-Like Cells That Is Related to EGF

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3522611

Structure of heparin-binding EGF-like growth factor. Multiple forms, primary structure, and glycosylation of the mature protein

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3522611

The stress- and inflammatory cytokine-induced ectodomain shedding of heparin-binding epidermal growth factor-like growth factor is mediated by p38 MAPK, distinct from the 12-O-tetradecanoylphorbol-13-acetate- and lysophosphatidic acid-induced signal

7 July 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0051964

Cardiac hypertrophy is inhibited by antagonism of ADAM12 processing of HB-EGF: metalloproteinase inhibitors as a new therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0051964

Clinical significance of heparin-binding epidermal growth factor-like growth factor and a disintegrin and metalloprotease 17 expression in human ovarian cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0051964

A novel anti-human HB-EGF monoclonal antibody with multiple antitumor mechanisms against ovarian cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0051964

Comparing protein VEGF inhibitors: In vitro biological studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0051964

Allosteric binding properties of a monoclonal antibody and its Fab fragment

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0051964

Heparin-binding epidermal growth factor-like growth factor: p91 activation induction of plasminogen activator/inhibitor, and tubular morphogenesis in human microvascular endothelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0051964

Diphtheria toxin:receptor interaction: association, dissociation, and effect of pH.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0051964

Up-regulated expression of ADAM17 in gastrointestinal stromal tumors: coexpression with EGFR and EGFR ligands.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0051964

A site-directed mutagenesis study on the role of isoleucine-23 of human epidermal growth factor in the receptor binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0051964

HB-EGF promotes epithelial cell migration in eyelid development

21 January 2018

1 reference

12 December 2020

Expression and regulation of c-ERBB ligands in human head and neck squamous carcinoma cells

1 reference

12 December 2020

Critical functional requirement for the guanidinium group of the arginine 41 side chain of human epidermal growth factor as revealed by mutagenic inactivation and chemical reactivation

1 reference

12 December 2020

Human epidermal growth factor

1 reference

12 December 2020

Possible role of coexpression of CD9 with membrane-anchored heparin-binding EGF-like growth factor and amphiregulin in cultured human keratinocyte growth

1 reference

12 December 2020

Intercellular communication between vascular smooth muscle and endothelial cells mediated by heparin-binding epidermal growth factor-like growth factor and vascular endothelial growth factor

1 reference

12 December 2020

Biological efficacy of a chimeric antibody to the epidermal growth factor receptor in a human tumor xenograft model

1 reference

12 December 2020

10.1371/JOURNAL.PONE.0051964

Identifiers

DOI

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2 August 2017

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2 August 2017

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