(Q34518559)

2 August 2017

title

A hypusine-eIF5A-PEAK1 switch regulates the pathogenesis of pancreatic cancer (English)

1 reference

2 August 2017

0 references

1 reference

Ken Fujimura

1

1 reference

2 August 2017

Tracy Wright

2

1 reference

2 August 2017

Jan Strnadel

3

1 reference

2 August 2017

Sharmeela Kaushal

4

1 reference

2 August 2017

Cristina Metildi

5

1 reference

2 August 2017

Andrew M Lowy

6

1 reference

2 August 2017

Michael Bouvet

7

1 reference

2 August 2017

Jonathan A Kelber

8

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2 August 2017

Richard L Klemke

9

1 reference

2 August 2017

language of work or name

English

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publication date

26 September 2014

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2 August 2017

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2 August 2017

volume

74

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2 August 2017

issue

22

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2 August 2017

page(s)

6671-6681

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describes a project that uses

2 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4233190/fullTextXML

inferred from PubMed Central ID database lookup

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KRas induces a Src/PEAK1/ErbB2 kinase amplification loop that drives metastatic growth and therapy resistance in pancreatic cancer

7 July 2018

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7 July 2018

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7 July 2018

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Pseudopodium-enriched atypical kinase 1 regulates the cytoskeleton and cancer progression [corrected].

7 July 2018

1 reference

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The unique hypusine modification of eIF5A promotes islet beta cell inflammation and dysfunction in mice

7 July 2018

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eIF5A promotes translation elongation, polysome disassembly and stress granule assembly

7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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Up-regulation of miR-200 and let-7 by natural agents leads to the reversal of epithelial-to-mesenchymal transition in gemcitabine-resistant pancreatic cancer cells

7 July 2018

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7 July 2018

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Hypusine-containing protein eIF5A promotes translation elongation

7 July 2018

1 reference

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7 July 2018

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7 July 2018

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7 July 2018

1 reference

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The post-translational synthesis of a polyamine-derived amino acid, hypusine, in the eukaryotic translation initiation factor 5A (eIF5A)

7 July 2018

1 reference

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7 July 2018

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Aberrant mRNA translation in cancer pathogenesis: an old concept revisited comes finally of age.

7 July 2018

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7 July 2018

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Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma

7 July 2018

1 reference

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Immortalization with telomerase of the Nestin-positive cells of the human pancreas

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233190

Isolation of a novel candidate oncogene within a frequently amplified region at 3q26 in ovarian cancer.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233190

The importance of being proline: the interaction of proline-rich motifs in signaling proteins with their cognate domains

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233190

The polyproline region of p53 is required to activate apoptosis but not growth arrest.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233190

Effects of N1-guanyl-1,7-diaminoheptane, an inhibitor of deoxyhypusine synthase, on the growth of tumorigenic cell lines in culture

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233190

Inhibition of ribonucleotide reduction in CCRF-CEM cells by 2',2'-difluorodeoxycytidine

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233190

Translation initiation factor 5A and its hypusine modification are essential for cell viability in the yeast Saccharomyces cerevisiae

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233190

EF-P is essential for rapid synthesis of proteins containing consecutive proline residues

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233190

Translation elongation factor EF-P alleviates ribosome stalling at polyproline stretches.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233190

Overexpression of EIF5A2 promotes colorectal carcinoma cell aggressiveness by upregulating MTA1 through C-myc to induce epithelial-mesenchymaltransition.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233190

Chelation of intracellular iron with the antifungal agent ciclopirox olamine induces cell death in leukemia and myeloma cells.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233190

The antifungal drug ciclopirox inhibits deoxyhypusine and proline hydroxylation, endothelial cell growth and angiogenesis in vitro

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233190

Identification of genes upregulated in ALK-positive and EGFR/KRAS/ALK-negative lung adenocarcinomas

27 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25261239

12 December 2020

inferred from PubMed ID database lookup

Oral ciclopirox olamine displays biological activity in a phase I study in patients with advanced hematologic malignancies

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25261239

12 December 2020

inferred from PubMed ID database lookup

Hypusination of eukaryotic initiation factor 5A (eIF5A): a novel therapeutic target in BCR-ABL-positive leukemias identified by a proteomics approach

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25261239

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1158/0008-5472.CAN-14-1031

1 reference

2 August 2017

1 reference

2 August 2017

1 reference