(Q34519677)

PubMed publication ID

2 August 2017

1 reference

title

Recent developments in the discovery of novel adenosine kinase inhibitors: mechanism of action and therapeutic potential (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6741667&resulttype=core&format=json

12 May 2020

author name string

S McGaraughty

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6741667&resulttype=core&format=json

12 May 2020

M Cowart

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6741667&resulttype=core&format=json

12 May 2020

M F Jarvis

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6741667&resulttype=core&format=json

12 May 2020

publication date

1 January 2001

1 reference

PubMed publication ID

11830758

CNS Neuroscience & Therapeutics

2 August 2017

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6741667&resulttype=core&format=json

12 May 2020

volume

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6741667&resulttype=core&format=json

12 May 2020

issue

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6741667&resulttype=core&format=json

12 May 2020

page(s)

415-432

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6741667&resulttype=core&format=json

Adenosine kinase inhibitors.

12 May 2020

cites work

1 reference

12 December 2020

Adenosine kinase inhibitors as a novel approach to anticonvulsant therapy.

1 reference

12 December 2020

Characterization of the effects of adenosine kinase inhibitors on acute thermal nociception in mice

1 reference

12 December 2020

Site and event specific increase of striatal adenosine release by adenosine kinase inhibition in rats

1 reference

12 December 2020

Purinergic and pyrimidinergic receptors as potential drug targets

1 reference

12 December 2020

P2Y(1) purinoceptor-mediated Ca(2+) signaling and Ca(2+) wave propagation in dorsal spinal cord astrocytes.

1 reference

12 December 2020

Neuronal plasticity: increasing the gain in pain

1 reference

12 December 2020

Adenosine kinase inhibitors. 1. Synthesis, enzyme inhibition, and antiseizure activity of 5-iodotubercidin analogues

1 reference

12 December 2020

Adenosine kinase inhibitors. 2. Synthesis, enzyme inhibition, and antiseizure activity of diaryltubercidin analogues

1 reference

12 December 2020

P2 purinergic receptors: modulation of cell function and therapeutic potential

1 reference

12 December 2020

ABT-702 (4-amino-5-(3-bromophenyl)-7-(6-morpholinopyridin-3-yl)pyrido[2, 3-d]pyrimidine), a novel orally effective adenosine kinase inhibitor with analgesic and anti-inflammatory properties: I. In vitro characterization and acute antinociceptive eff

1 reference

12 December 2020

ABT-702 (4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin- 3-yl)pyrido[2,3-d]pyrimidine), a novel orally effective adenosine kinase inhibitor with analgesic and anti-inflammatory properties. II. In vivo characterization in the rat

1 reference

12 December 2020

Design of adenosine kinase inhibitors from the NMR-based screening of fragments

1 reference

12 December 2020

Structure-activity studies of 5-substituted pyridopyrimidines as adenosine kinase inhibitors

1 reference

12 December 2020

Anti-inflammatory effects of ABT-702, a novel non-nucleoside adenosine kinase inhibitor, in rat adjuvant arthritis.

1 reference

12 December 2020

Effects of A-134974, a novel adenosine kinase inhibitor, on carrageenan-induced inflammatory hyperalgesia and locomotor activity in rats: evaluation of the sites of action

1 reference

12 December 2020

The effect of ABT-702, a novel adenosine kinase inhibitor, on the responses of spinal neurones following carrageenan inflammation and peripheral nerve injury

1 reference

12 December 2020

Discovery of 4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin-3-yl)pyrido[2,3-d]pyrimidine, an orally active, non-nucleoside adenosine kinase inhibitor..

1 reference

12 December 2020

A-134974: a novel adenosine kinase inhibitor, relieves tactile allodynia via spinal sites of action in peripheral nerve injured rats

1 reference

12 December 2020

Synthesis and antiviral properties of (+/-)-5'-noraristeromycin and related purine carbocyclic nucleosides. A new lead for anti-human cytomegalovirus agent design

1 reference

12 December 2020

Spinally-mediated antinociception is induced in mice by an adenosine kinase-, but not by an adenosine deaminase-, inhibitor

1 reference

12 December 2020

Adenosine: a potential mediator of seizure arrest and postictal refractoriness

1 reference

12 December 2020

Therapeutic potential for adenosine receptor activation in ischemic brain injury

1 reference

12 December 2020

Structural requirements for activity of nucleosides as substrates for adenosine kinase: orientation of substituents on the pentofuranosyl ring

1 reference

12 December 2020

Adenosine kinase from rabbit liver. II. Substrate and inhibitor specificity

1 reference

12 December 2020

Turnover of adenosine in plasma of human and dog blood

1 reference

12 December 2020

Regulation of adenosine kinase by adenosine analogs

1 reference

12 December 2020

How does adenosine inhibit transmitter release?

1 reference

12 December 2020

Adenosine kinase from human erythrocytes: kinetic studies and characterization of adenosine binding sites

1 reference

12 December 2020

Adenosine reduces cortical neuronal injury induced by oxygen or glucose deprivation in vitro

1 reference

12 December 2020

An adenosine analogue, 2-chloroadenosine, protects against long term development of ischaemic cell loss in the rat hippocampus

1 reference

12 December 2020

Consequences of activation and adenosine-mediated inhibition of granulocytes during myocardial ischemia

1 reference

12 December 2020

Quantitative autoradiographic analysis of muscarinic cholinergic and adenosine A1 binding sites after transient forebrain ischemia in the gerbil

1 reference

12 December 2020

The control of the metabolism and the hormonal role of adenosine

1 reference

12 December 2020

Characterization of the antinociceptive effects of some adenosine analogues in the rat

1 reference

12 December 2020

Is adenosine an endogenous anticonvulsant?

1 reference

12 December 2020

Metabolic studies with carbocyclic analogs of purine nucleosides

1 reference

12 December 2020

Halogenated pyrrolopyrimidine analogues of adenosine from marine organisms: Pharmacological activities and potent inhibition of adenosine kinase

1 reference

12 December 2020

The control of adenosine concentration in polymorphonuclear leucocytes, cultured heart cells and isolated perfused heart from the rat.

1 reference

12 December 2020

Changes in brain adenosine during bicuculline-induced seizures in rats. Effects of hypoxia and altered systemic blood pressure

1 reference

12 December 2020

The antiinflammatory effects of an adenosine kinase inhibitor are mediated by adenosine

1 reference

12 December 2020

Anti-inflammatory effects of an adenosine kinase inhibitor. Decreased neutrophil accumulation and vascular leakage

1 reference

12 December 2020

Inhibition of adenosine kinase increases endogenous adenosine and depresses neuronal activity in hippocampal slices

1 reference

12 December 2020

Intrinsic tryptophan fluorescence of bovine liver adenosine kinase, characterization of ligand binding sites and conformational changes

1 reference

12 December 2020

Protective effect of an adenosine kinase inhibitor in septic shock

1 reference

12 December 2020

New adenosine kinase inhibitors with oral antiinflammatory activity: synthesis and biological evaluation

1 reference

12 December 2020

The adenosine kinase inhibitor, 5-iodotubercidin, is not protective against cerebral ischemic injury in the gerbil

1 reference

12 December 2020

Manipulation of endogenous adenosine in the rat prepiriform cortex modulates seizure susceptibility

1 reference

12 December 2020

Cloning of human adenosine kinase cDNA: sequence similarity to microbial ribokinases and fructokinases

1 reference

12 December 2020

Antinociception by adenosine analogs and an adenosine kinase inhibitor: dependence on formalin concentration

1 reference

12 December 2020

Adenosine kinase inhibitors augment release of adenosine from spinal cord slices

1 reference

12 December 2020

Pre- and peristroke treatment with the adenosine kinase inhibitor, 5'-deoxyiodotubercidin, significantly reduces infarct volume after temporary occlusion of the middle cerebral artery in rats

1 reference

12 December 2020

Spinal cord adenosine receptor stimulation in rats inhibits peripheral neutrophil accumulation. The role of N-methyl-D-aspartate receptors

1 reference

12 December 2020

Adenosine kinase inhibition protects brain against transient focal ischemia in rats

1 reference

12 December 2020

Cloning and expression of the adenosine kinase gene from rat and human tissues

1 reference

12 December 2020

Adenosine for pain control.

1 reference

12 December 2020

The effect of GP683, an adenosine kinase inhibitor, on the desflurane anesthetic requirement in dogs.

1 reference

12 December 2020

Peripheral antinociceptive effect of an adenosine kinase inhibitor, with augmentation by an adenosine deaminase inhibitor, in the rat formalin test

1 reference

12 December 2020

Antinociception by adenosine analogs and inhibitors of adenosine metabolism in an inflammatory thermal hyperalgesia model in the rat

1 reference

12 December 2020

Delayed treatment with an adenosine kinase inhibitor, GP683, attenuates infarct size in rats with temporary middle cerebral artery occlusion

1 reference

12 December 2020

Inhibition of adenosine kinase during oxygen-glucose deprivation in rat cortical neuronal cultures

1 reference

12 December 2020

Structure of human adenosine kinase at 1.5 A resolution

1 reference

12 December 2020

An adenosine kinase inhibitor attenuates tactile allodynia in a rat model of diabetic neuropathic pain

1 reference

12 December 2020

10.1111/J.1527-3458.2001.TB00208.X

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6741667&resulttype=core&format=json

12 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6741667&resulttype=core&format=json

12 May 2020

PubMed publication ID

11830758

1 reference