(Q34540047)

2 August 2017

title

Endoglin requirement for BMP9 signaling in endothelial cells reveals new mechanism of action for selective anti-endoglin antibodies (English)

1 reference

2 August 2017

0 references

1 reference

Olivier Nolan-Stevaux

1

1 reference

2 August 2017

Wendy Zhong

2

1 reference

2 August 2017

Stacey Culp

3

1 reference

2 August 2017

Kathy Shaffer

4

1 reference

2 August 2017

Joseph Hoover

5

1 reference

2 August 2017

Dineli Wickramasinghe

6

1 reference

2 August 2017

Astrid Ruefli-Brasse

7

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2 August 2017

language of work or name

English

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publication date

27 December 2012

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2 August 2017

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2 August 2017

volume

7

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2 August 2017

issue

12

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2 August 2017

page(s)

e50920

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Creative Commons Attribution 4.0 International

2 August 2017

copyright license

start time

27 December 2012

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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Anti-human activin receptor-like kinase 1 (ALK1) antibody attenuates bone morphogenetic protein 9 (BMP9)-induced ALK1 signaling and interferes with endothelial cell sprouting

7 July 2018

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Structural and functional insights into endoglin ligand recognition and binding.

7 July 2018

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Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10 via its orphan domain, inhibits blood vessel formation, and suppresses tumor growth

7 July 2018

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TGF-β receptor signaling pathways in angiogenesis; emerging targets for anti-angiogenesis therapy.

7 July 2018

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ALK1 as an emerging target for antiangiogenic therapy of cancer

7 July 2018

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Endoglin promotes TGF-β/Smad1 signaling in scleroderma fibroblasts

7 July 2018

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7 July 2018

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The physiological role of endoglin in the cardiovascular system.

7 July 2018

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Signaling by members of the TGF-beta family in vascular morphogenesis and disease

7 July 2018

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ALK1-Fc inhibits multiple mediators of angiogenesis and suppresses tumor growth

7 July 2018

1 reference

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Genetic and pharmacological targeting of activin receptor-like kinase 1 impairs tumor growth and angiogenesis.

7 July 2018

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7 July 2018

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Expression of vascular endothelial growth factor is coordinately regulated by the activin-like kinase receptors 1 and 5 in endothelial cells

7 July 2018

1 reference

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Emerging role of bone morphogenetic proteins in angiogenesis

7 July 2018

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Mural cell associated VEGF is required for organotypic vessel formation

7 July 2018

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Bone morphogenetic protein (BMP) and activin type II receptors balance BMP9 signals mediated by activin receptor-like kinase-1 in human pulmonary artery endothelial cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3531442

TGFbeta-stimulated Smad1/5 phosphorylation requires the ALK5 L45 loop and mediates the pro-migratory TGFbeta switch

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3531442

Transforming growth factor beta-induced Smad1/5 phosphorylation in epithelial cells is mediated by novel receptor complexes and is essential for anchorage-independent growth

7 July 2018

1 reference

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Endoglin (CD105): a marker of tumor vasculature and potential target for therapy

7 July 2018

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Bone morphogenetic protein-9 is a circulating vascular quiescence factor

7 July 2018

1 reference

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Anti-tumor activity of an anti-endoglin monoclonal antibody is enhanced in immunocompetent mice

7 July 2018

1 reference

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Endoglin-mediated vascular remodeling: mechanisms underlying hereditary hemorrhagic telangiectasia

7 July 2018

1 reference

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Extracellular control of TGFbeta signalling in vascular development and disease

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3531442

BMP-9 signals via ALK1 and inhibits bFGF-induced endothelial cell proliferation and VEGF-stimulated angiogenesis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3531442

Reduced tumor growth and angiogenesis in endoglin-haploinsufficient mice

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3531442

Structural model of human endoglin, a transmembrane receptor responsible for hereditary hemorrhagic telangiectasia.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3531442

Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3531442

Crystal structure of BMP-9 and functional interactions with pro-region and receptors

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3531442

Interaction and functional interplay between endoglin and ALK-1, two components of the endothelial transforming growth factor-beta receptor complex

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3531442

Endoglin promotes endothelial cell proliferation and TGF-beta/ALK1 signal transduction

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3531442

Loss of distinct arterial and venous boundaries in mice lacking endoglin, a vascular-specific TGFbeta coreceptor

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3531442

Activin receptor-like kinase 1 is implicated in the maturation phase of angiogenesis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3531442

Balancing the activation state of the endothelium via two distinct TGF-beta type I receptors

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3531442

How cells read TGF-beta signals

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3531442

Arteriovenous malformations in mice lacking activin receptor-like kinase-1

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3531442

A murine model of hereditary hemorrhagic telangiectasia

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3531442

Expression analysis of four endoglin missense mutations suggests that haploinsufficiency is the predominant mechanism for hereditary hemorrhagic telangiectasia type 1.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3531442

Defective angiogenesis in mice lacking endoglin

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3531442

Endoglin forms a heteromeric complex with the signaling receptors for transforming growth factor-beta

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3531442

Endoglin is a component of the transforming growth factor-beta receptor system in human endothelial cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3531442

Transforming Growth Factor {beta} Can Stimulate Smad1 Phosphorylation Independently of Bone Morphogenic Protein Receptors

7 July 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0050920

Matrix GLA protein stimulates VEGF expression through increased transforming growth factor-beta1 activity in endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0050920

Blood outgrowth endothelial cells from Hereditary Haemorrhagic Telangiectasia patients reveal abnormalities compatible with vascular lesions

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0050920

BMP9 is produced by hepatocytes and circulates mainly in an active mature form complexed to its prodomain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0050920

Transforming growth factor-beta1 circulates in normal human plasma and is unchanged in advanced metastatic breast cancer

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23300529

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Endoglin structure and function: Determinants of endoglin phosphorylation by transforming growth factor-beta receptors

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23300529

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

An in vitro model of angiogenesis: basic features

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23300529

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PONE.0050920

1 reference

2 August 2017

0 references

1 reference

2 August 2017

1 reference