(Q34547059)

2 August 2017

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title

Genes, telomeres and mammalian ageing (English)

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2 August 2017

Malcolm H Goyns

1

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2 August 2017

publication date

1 April 2002

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Mechanisms of Ageing and Development

2 August 2017

published in

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2 August 2017

volume

123

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2 August 2017

issue

7

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2 August 2017

page(s)

791-799

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Endogenous DNA damage as related to cancer and aging

2 August 2017

cites work

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Alteration of the adrenal antioxidant defense system during aging in rats

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Telomere shortening and tumor formation by mouse cells lacking telomerase RNA

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Extension of life-span by introduction of telomerase into normal human cells

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DNA damage, mutation and fine structure DNA repair in aging.

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7 January 2021

Telomerase activity in normal and malignant hematopoietic cells

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7 January 2021

Telomerase regulation during entry into the cell cycle in normal human T cells

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7 January 2021

The biology of replicative senescence

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7 January 2021

Differential display analysis can reveal patterns of gene expression in immortalised hepatoma cells which are similar to those observed in young adult but not old adult liver cells

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7 January 2021

DNA methylation and gene activity

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7 January 2021

Differential expression of telomerase activity in hematopoietic progenitors from adult human bone marrow

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7 January 2021

Telomerase activity in human ovarian carcinoma

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7 January 2021

Effect of dietary restriction on in vivo somatic mutation in mice.

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7 January 2021

Cellular and molecular mechanisms of aging

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7 January 2021

Rapid accumulation of genome rearrangements in liver but not in brain of old mice

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7 January 2021

Random intracellular drift explains the clonal expansion of mitochondrial DNA mutations with age.

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7 January 2021

Elevated levels of C-jun and c-fos transcripts in the aged rat liver

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7 January 2021

Differential display analysis of gene expression indicates that age-related changes are restricted to a small cohort of genes.

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7 January 2021

Telomere length regulation

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7 January 2021

Poly(ADP-ribose) polymerase activity in mononuclear leukocytes of 13 mammalian species correlates with species-specific life span

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7 January 2021

Intracellular oxidation/reduction status in the regulation of transcription factors NF-kappaB and AP-1.

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7 January 2021

Telomerase activity in the regenerative basal layer of the epidermis inhuman skin and in immortal and carcinoma-derived skin keratinocytes

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7 January 2021

Telomeres shorten during ageing of human fibroblasts

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7 January 2021

Aging: a theory based on free radical and radiation chemistry

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7 January 2021

THE LIMITED IN VITRO LIFETIME OF HUMAN DIPLOID CELL STRAINS

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7 January 2021

Theories of biological aging

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7 January 2021

Impact of age and environment on somatic mutation at the hprt gene of T lymphocytes in humans

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7 January 2021

AP-1 function and regulation

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7 January 2021

Specific Association of Human Telomerase Activity with Immortal Cells and Cancer

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7 January 2021

Tissue-specific distribution of multiple mitochondrial DNA rearrangements during human aging

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7 January 2021

Increased expression of the S25 ribosomal protein gene occurs during ageing of the rat liver

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7 January 2021

Gene expression profile of aging and its retardation by caloric restriction

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7 January 2021

Gene-expression profile of the ageing brain in mice

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7 January 2021

Multiple mitochondrial DNA deletions associated with age in skeletal muscle of rhesus monkeys.

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7 January 2021

Comparative analysis of DNA mutations in lacI transgenic mice with age.

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7 January 2021

Association of age-related mitochondrial abnormalities with skeletal muscle fiber atrophy

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7 January 2021

Essential role of mouse telomerase in highly proliferative organs

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7 January 2021

Telomere end-replication problem and cell aging

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7 January 2021

Instability and decay of the primary structure of DNA

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7 January 2021

Cataloging altered gene expression in young and senescent cells using enhanced differential display

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7 January 2021

Mutations in mitochondrial DNA accumulate differentially in three different human tissues during ageing

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7 January 2021

Somatic mutations are frequent and increase with age in human kidney epithelial cells

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7 January 2021

Conservation of the human telomere sequence (TTAGGG)n among vertebrates

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7 January 2021

GFAP mRNA increases with age in rat and human brain

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7 January 2021

The concentration of glial fibrillary acidic protein increases with age in the mouse and rat brain.

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7 January 2021

DNA base modifications in chromatin of human cancerous tissues

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7 January 2021

A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon

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7 January 2021

Nuclear proto-oncogenes fos and jun.

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7 January 2021

Normal oxidative damage to mitochondrial and nuclear DNA is extensive

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7 January 2021

Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice

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7 January 2021

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7 January 2021

Fluorescence in situ hybridization analysis of the fos/jun ratio in the ageing brain

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7 January 2021

Down-regulation of Ku autoantigen, DNA-dependent protein kinase, and poly(ADP-ribose) polymerase during cellular senescence

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900424-9

7 January 2021

Altered composition and DNA binding activity of the AP-1 transcription factor during the ageing of human fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900424-9

7 January 2021

Effects of age on c-fos and c-myc gene expression in response to hemodynamic stress in isolated, perfused rat hearts

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900424-9

7 January 2021

Protein oxidation and aging

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900424-9

7 January 2021

ON THE NATURE OF THE AGING PROCESS

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900424-9

7 January 2021

Methylated cytosine level in human liver DNA does not decline in aging process

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https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900424-9

7 January 2021

Aging-associated deletions of human diaphragmatic mitochondrial DNA

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https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900424-9

7 January 2021

Analysis and modulation of DNA repair in aging

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https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900424-9

7 January 2021

Apoptosis: a two-edged sword in aging

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7 January 2021

PLEIOTROPY, NATURAL SELECTION, AND THE EVOLUTION OF SENESCENCE

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900424-9

7 January 2021

DNA methylation decreases in aging but not in immortal cells

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https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900424-9

7 January 2021

Damage to DNA by reactive oxygen and nitrogen species: role in inflammatory disease and progression to cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900424-9

7 January 2021

Positional cloning of the Werner's syndrome gene

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900424-9

7 January 2021

Role of oxidative stress in telomere length regulation and replicative senescence

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900424-9

7 January 2021

10.1016/S0047-6374(01)00424-9

Identifiers

DOI

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2 August 2017

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