(Q34547596)

2 August 2017

title

Characterization of the interaction of ingenol 3-angelate with protein kinase C. (English)

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2 August 2017

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1 reference

Noemi Kedei

1

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2 August 2017

Daniel J Lundberg

2

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2 August 2017

Attila Toth

3

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2 August 2017

Peter Welburn

4

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2 August 2017

Susan H Garfield

5

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2 August 2017

Peter M Blumberg

6

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2 August 2017

language of work or name

English

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publication date

1 May 2004

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2 August 2017

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2 August 2017

volume

64

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2 August 2017

issue

9

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2 August 2017

page(s)

3243-3255

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The extended protein kinase C superfamily

2 August 2017

cites work

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The paradigm of IL-6: from basic science to medicine

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Differential localization of protein kinase C delta by phorbol esters and related compounds using a fusion protein with green fluorescent protein

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Role of lymphotoxin in expression of interleukin 6 in human fibroblasts. Stimulation and regulation

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Overexpression of protein kinase C betaII induces colonic hyperproliferation and increased sensitivity to colon carcinogenesis

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12 April 2024

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Structural basis of binding of high-affinity ligands to protein kinase C: prediction of the binding modes through a new molecular dynamics method and evaluation by site-directed mutagenesis.

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Protein kinase Cdelta targets mitochondria, alters mitochondrial membrane potential, and induces apoptosis in normal and neoplastic keratinocytes when overexpressed by an adenoviral vector

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12 April 2024

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Arachidonic acid-induced IL-6 expression is mediated by PKC alpha activation in osteoblastic cells

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12 April 2024

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Unique T cell proliferation associated with PKCmu activation and impaired ZAP-70 phosphorylation in recognition of overexpressed HLA/partially agonistic peptide complexes.

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Interleukin-6 production by murine B cells and B cell lines

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Protein kinase C translocation by modified phorbol esters with functionalized lipophilic regions

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The use of fluorescent phorbol esters in studies of protein kinase C-membrane interactions

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12 April 2024

https://opencitations.net/index/api/v1/references/10.1158/0008-5472.CAN-03-3403

Protein kinase C as a molecular machine for decoding calcium and diacylglycerol signals

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12 April 2024

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The pathogenesis of squamous cell cancer: lessons learned from studies of skin carcinogenesis

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12 April 2024

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Skin tumor promotion by phorbol esters is a two-stage process

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12 April 2024

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The role of the calpain-calpastatin system in thyrotropin-releasing hormone-induced selective down-regulation of a protein kinase C isozyme, nPKC epsilon, in rat pituitary GH4C1 cells

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12 April 2024

https://opencitations.net/index/api/v1/references/10.1158/0008-5472.CAN-03-3403

HOME TREATMENT OF SKIN CANCER AND SOLAR KERATOSES

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12 April 2024

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Activation of latent HIV-1 expression by the potent anti-tumor promoter 12-deoxyphorbol 13-phenylacetate

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12 April 2024

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Modulation of lipopolysaccharide-induced NF-IL6 activation by protein kinase C-alpha in a mouse macrophage cell line

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12 April 2024

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Targeted disruption of the IL-6 related genes: gp130 and NF-IL-6.

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12 April 2024

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Biologically active diterpene esters from euphorbia peplus

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12 April 2024

https://opencitations.net/index/api/v1/references/10.1158/0008-5472.CAN-03-3403

Solution structure of a cysteine rich domain of rat protein kinase C.

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12 April 2024

https://opencitations.net/index/api/v1/references/10.1158/0008-5472.CAN-03-3403

Direct visualization of the translocation of the gamma-subspecies of protein kinase C in living cells using fusion proteins with green fluorescent protein

1 reference

12 April 2024

https://opencitations.net/index/api/v1/references/10.1158/0008-5472.CAN-03-3403

Dramatic switching of protein kinase C agonist/antagonist activity by modifying the 12-ester side chain of phorbol esters

1 reference

12 April 2024

https://opencitations.net/index/api/v1/references/10.1158/0008-5472.CAN-03-3403

Active site mutations of Pseudomonas aeruginosa exotoxin A. Analysis of the His440 residue

1 reference

12 April 2024

https://opencitations.net/index/api/v1/references/10.1158/0008-5472.CAN-03-3403

Diacylglycerol (DAG)-lactones, a new class of protein kinase C (PKC) agonists, induce apoptosis in LNCaP prostate cancer cells by selective activation of PKCalpha

1 reference

12 April 2024

https://opencitations.net/index/api/v1/references/10.1158/0008-5472.CAN-03-3403

Bryostatin, an activator of the calcium phospholipid-dependent protein kinase, blocks phorbol ester-induced differentiation of human promyelocytic leukemia cells HL-60.

1 reference

12 April 2024

https://opencitations.net/index/api/v1/references/10.1158/0008-5472.CAN-03-3403

Non-promoting 12-deoxyphorbol 13-esters as potent inhibitors of phorbol 12-myristate 13-acetate-induced acute and chronic biological responses in CD-1 mouse skin

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12 April 2024

https://opencitations.net/index/api/v1/references/10.1158/0008-5472.CAN-03-3403

The atypical protein kinase Cs. Functional specificity mediated by specific protein adapters

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12 April 2024

https://opencitations.net/index/api/v1/references/10.1158/0008-5472.CAN-03-3403

Proteasome implication in phorbol ester- and GnRH-induced selective down-regulation of PKC (alpha, epsilon, zeta) in alpha T(3)-1 and L beta T(2) gonadotrope cell lines

1 reference

12 April 2024

https://opencitations.net/index/api/v1/references/10.1158/0008-5472.CAN-03-3403

Contributions to maxima in protein kinase C activation

1 reference

12 April 2024

https://opencitations.net/index/api/v1/references/10.1158/0008-5472.CAN-03-3403

Bryostatin 1, an activator of protein kinase C, inhibits tumor promotion by phorbol esters in SENCAR mouse skin

1 reference

12 April 2024

https://opencitations.net/index/api/v1/references/10.1158/0008-5472.CAN-03-3403

Roles of ionic residues of the C1 domain in protein kinase C-alpha activation and the origin of phosphatidylserine specificity.

1 reference

12 April 2024

https://opencitations.net/index/api/v1/references/10.1158/0008-5472.CAN-03-3403

Synergistic Stimulation of Interleukin 6 Release and Gene Expression by Phorbol Esters and Interleukin 1β in Rat Cortical Astrocytes: Role of Protein Kinase C Activation and Blockade

1 reference

12 April 2024

https://opencitations.net/index/api/v1/references/10.1158/0008-5472.CAN-03-3403

Contribution of the C1A and C1B Domains to the Membrane Interaction of Protein Kinase C

1 reference

12 April 2024

https://opencitations.net/index/api/v1/references/10.1158/0008-5472.CAN-03-3403

Protein kinase C: structural and spatial regulation by phosphorylation, cofactors, and macromolecular interactions

1 reference

12 April 2024

https://opencitations.net/index/api/v1/references/10.1158/0008-5472.CAN-03-3403

Protein Kinase C- (PKC- ): Its Unique Structure and Function

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12 April 2024

https://opencitations.net/index/api/v1/references/10.1158/0008-5472.CAN-03-3403

The potential role of PKC beta in diabetic retinopathy and macular edema

1 reference

12 April 2024

https://opencitations.net/index/api/v1/references/10.1158/0008-5472.CAN-03-3403

[3H]Phorbol 12,13-dibutyrate binding assay for protein kinase C and related proteins

1 reference

12 April 2024

https://opencitations.net/index/api/v1/references/10.1158/0008-5472.CAN-03-3403

Isoenzymes of protein kinase C: differential involvement in apoptosis and pathogenesis

1 reference

12 April 2024

https://opencitations.net/index/api/v1/references/10.1158/0008-5472.CAN-03-3403

Low affinity binding of phorbol esters to protein kinase C and its recombinant cysteine-rich region in the absence of phospholipids

1 reference

12 April 2024

https://opencitations.net/index/api/v1/references/10.1158/0008-5472.CAN-03-3403

Adenovirus-mediated gene transfer to keratinocytes--a review

1 reference

12 April 2024

https://opencitations.net/index/api/v1/references/10.1158/0008-5472.CAN-03-3403

Prospects for targeting protein kinase C isozymes in the therapy of drug-resistant cancer--an evolving story

1 reference

12 April 2024

https://opencitations.net/index/api/v1/references/10.1158/0008-5472.CAN-03-3403

The lipophilicity of phorbol esters as a critical factor in determining the pattern of translocation of protein kinase C delta fused to green fluorescent protein

1 reference

12 April 2024

https://opencitations.net/index/api/v1/references/10.1158/0008-5472.CAN-03-3403

Involvement of PKC-beta in PTH, TNF-alpha, and IL-1 beta effects on IL-6 promoter in osteoblastic cells and on PTH-stimulated bone resorption

1 reference

12 April 2024

https://opencitations.net/index/api/v1/references/10.1158/0008-5472.CAN-03-3403

Increased proliferation of B cells and auto-immunity in mice lacking protein kinase Cdelta

1 reference

12 April 2024

https://opencitations.net/index/api/v1/references/10.1158/0008-5472.CAN-03-3403

Protein kinase C isozymes and the regulation of diverse cell responses

1 reference

12 April 2024

https://opencitations.net/index/api/v1/references/10.1158/0008-5472.CAN-03-3403

Novel "nonkinase" phorbol ester receptors: the C1 domain connection

1 reference

12 April 2024

https://opencitations.net/index/api/v1/references/10.1158/0008-5472.CAN-03-3403

Effect of intravenous infusions of 12-O-tetradecanoylphorbol-13-acetate (TPA) in patients with myelocytic leukemia: preliminary studies on therapeutic efficacy and toxicity

1 reference

12 April 2024

https://opencitations.net/index/api/v1/references/10.1158/0008-5472.CAN-03-3403

Getting to know protein kinase D.

1 reference

12 April 2024

https://opencitations.net/index/api/v1/references/10.1158/0008-5472.CAN-03-3403

Regulation of IL6 gene expression

1 reference

12 April 2024

https://opencitations.net/index/api/v1/references/10.1158/0008-5472.CAN-03-3403

Biological assays for irritant tumor-initiating and -promoting activities. I. Kinetics of the irritant response in relation to the initiation-promoting activity of polyfunctional diterpenes representing tigliane and some daphnane types

1 reference

12 April 2024

https://opencitations.net/index/api/v1/references/10.1158/0008-5472.CAN-03-3403

Crystal structure of the cys2 activator-binding domain of protein kinase C delta in complex with phorbol ester

1 reference

12 April 2024

https://opencitations.net/index/api/v1/references/10.1158/0008-5472.CAN-03-3403

Multiple regulatory elements in the interleukin-6 gene mediate induction by prostaglandins, cyclic AMP, and lipopolysaccharide.

1 reference

12 April 2024

https://opencitations.net/index/api/v1/references/10.1158/0008-5472.CAN-03-3403

The clinical development of the bryostatins

1 reference

12 April 2024

https://opencitations.net/index/api/v1/references/10.1158/0008-5472.CAN-03-3403

Synergistic effects of diacylglycerols and fatty acids on membrane structure and protein kinase C activity.

1 reference

12 April 2024

https://opencitations.net/index/api/v1/references/10.1158/0008-5472.CAN-03-3403

Establishment of a binding assay for protein kinase C isozymes using synthetic C1 peptides and development of new medicinal leads with protein kinase C isozyme and C1 domain selectivity

1 reference

12 April 2024

https://opencitations.net/index/api/v1/references/10.1158/0008-5472.CAN-03-3403

Contrasting effects of the protein kinase C inhibitor staurosporine on the interleukin-1 and phorbol ester activation pathways in the EL4-6.1 thymoma cell line

1 reference

12 April 2024

https://opencitations.net/index/api/v1/references/10.1158/0008-5472.CAN-03-3403

Synthetic diacylglycerols (DAG) and DAG-lactones as activators of protein kinase C (PK-C).

1 reference

12 April 2024

https://opencitations.net/index/api/v1/references/10.1158/0008-5472.CAN-03-3403

Protein kinase C alpha (PKC alpha): regulation and biological function

1 reference

12 April 2024

https://opencitations.net/index/api/v1/references/10.1158/0008-5472.CAN-03-3403

The catalytic domain of protein kinase Cdelta confers protection from down-regulation induced by bryostatin 1.

1 reference

12 April 2024

https://opencitations.net/index/api/v1/references/10.1158/0008-5472.CAN-03-3403

Conformationally constrained analogues of diacylglycerol (DAG). 16. How much structural complexity is necessary for recognition and high binding affinity to protein kinase C?

1 reference

12 April 2024

https://opencitations.net/index/api/v1/references/10.1158/0008-5472.CAN-03-3403

Evidence for an altered protein kinase C (PKC) signaling pathway in psoriasis

1 reference

12 April 2024

https://opencitations.net/index/api/v1/references/10.1158/0008-5472.CAN-03-3403

Identifiers

DOI

10.1158/0008-5472.CAN-03-3403

1 reference

2 August 2017

1 reference