(Q34557926)

3 August 2017

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title

Active drug metabolites. An overview of their relevance in clinical pharmacokinetics (English)

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3 August 2017

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Garattini S

1

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3 August 2017

publication date

1 May 1985

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Clinical Pharmacokinetics

3 August 2017

published in

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3 August 2017

volume

10

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3 August 2017

issue

3

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3 August 2017

page(s)

216-227

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Specific tricyclic antidepressant binding sites in rat brain

3 August 2017

cites work

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12 December 2020

Binding of [14C]-adriamycin to cellular macromolecules in vivo

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12 December 2020

Different synaptic location of mianserin and imipramine binding sites

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12 December 2020

Daunorubicinol, a major metabolite of daunorubicin: isolation from human urine and enzymatic reactions

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12 December 2020

The Effect of Altered Function of Dopaminergic Neurones on the Cholinergic System in the Striatum

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12 December 2020

Modulation of neuronal serotonin uptake by a putative endogenous ligand of imipramine recognition sites

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12 December 2020

Brain concentrations of clobazam and N-desmethylclobazam and antileptazol activity

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12 December 2020

Metabolic and pharmacological studies with N-methyl-N'-methyl-2'-allyl-2-benzoyl-4-chloro-glycinanilide (F 1797).

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12 December 2020

The antidepressant effects of trazodone and inhibition of platelet serotonin reuptake

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12 December 2020

The site of dopamine formation in rat striatum after L-dopa administration

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12 December 2020

Effect of two non tricyclic antidepressant drugs on [14C]5-hydroxytryptamine uptake by rat platelets

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12 December 2020

The in vivo and in vitro occupation of [3H]-spiperone binding sites in the frontal cortex and striatum by putative 5-hydroxytryptamine antagonists

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12 December 2020

Clinical Pharmacokinetics of Prednisone and Prednisolone

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12 December 2020

Selective inhibition of serotonin uptake by trazodone, a new antidepressant agent

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12 December 2020

Chlorophenylpiperazine: a central serotonin agonist causing powerful anorexia in rats

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12 December 2020

Role of one-electron and two-electron reduction products of adriamycin and daunomycin in deoxyribonucleic acid binding

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12 December 2020

Species differences in the kinetics and metabolism of fenfluramine isomers

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12 December 2020

Notes on buspirone's mechanisms of action.

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12 December 2020

Time-dependence in benzodiazepine pharmacokinetics. Mechanisms and clinical significance

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12 December 2020

Plasma concentrations of trazodone and 1-(3-chlorophenyl)piperazine in man after a single oral dose of trazodone

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12 December 2020

Anorectic effect of fenfluramine isomers and metabolites: relationship between brain levels and in vitro potencies on serotonergic mechanisms

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12 December 2020

A general mechanism for microsomal activation of quinone anticancer agents to free radicals

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12 December 2020

Molecular geometry of inhibitors of the uptake of catecholamines and serotonin in synaptosomal preparations of rat brain

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12 December 2020

Determination of plasma and brain concentrations of trazodone and its metabolite, l-m-chlorophenylpiperazine, by gas-liquid chromatography

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12 December 2020

Toxicity and antitumor activity of hexamethylmelamine and its N-demethylated metabolites in mice with transplantable tumors

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12 December 2020

N-Hydroxymethylpentamethylmelamine, a major in vitro metabolite of hexamethylmelamine

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12 December 2020

The effects of microiontophoretically applied trazodone on single neurones in the rat brainstem

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12 December 2020

Diazepam metabolism during chronic medication unbound fraction in plasma, erythrocytes and urine

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12 December 2020

Intact rat liver nuclei catalyze adriamycin irreversible interactions with DNA and nuclear proteins

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12 December 2020

Benzodiazepines: clinical pharmacology and therapeutic use.

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12 December 2020

3H-reserpine persistently bound "in vivo" to rat brain subcellular components: limited removal by peanut oil extraction

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12 December 2020

Antileptazol activity and kinetics of clobazam and N-desmethyl-clobazam in the guinea-pig

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12 December 2020

Does acute L-DOPA increase active release of dopamine from dopaminergic neurons?

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12 December 2020

Plasma levels of salicylate and aspirin in healthy volunteers: relevance to drug interaction on platelet function

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12 December 2020

Different sensitivity of two Walker 256 carcinoma lines to cyclophosphamide: correlation with drug distribution, biotransformation and macromolecule binding

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12 December 2020

Identification and quantitation of 1-(2-pyrimidinyl)piperazine, an active metabolite of the anxiolytic agent buspirone, in rat plasma and brain

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12 December 2020

The comparative efficacy of buspirone and diazepam in the treatment of anxiety

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12 December 2020

(—)-m-Chlorophenyl-piperazine, a central 5-hydroxytryptamine agonist, is a metabolite of trazodone

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12 December 2020

Salicylate-aspirin interaction and thrombosis prevention trials

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12 December 2020

Relationship between camazepam, N-methyl-oxazepam and oxazepam brain concentrations and antileptazol effect in the rat

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12 December 2020

The effect of etoperidone, a new potential antidepressant drug, on the central serotonin system

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12 December 2020

The anticancer agent adriamycin can be actively cytotoxic without entering cells

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12 December 2020

Central mechanisms of fenfluramine and related anorectic drugs

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12 December 2020

Differences between d-fenfluramine and d-norfenfluramine in serotonin presynaptic mechanisms

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12 December 2020

Cytotoxic activity of in vitro activated cyclophosphamide on tumors in primary culture

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12 December 2020

Some studies of the active intermediates formed in the microsomal metabolism of cyclophosphamide and isophosphamide

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12 December 2020

Pharmacological properties of AF 1161, a new psychotropic drug

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12 December 2020

In vivo and in vitro irreversible binding of hexamethylmelamine to liver and ovarian tumor macromolecules of mice

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12 December 2020

Stereoselective disposition of fenfluramine enantiomers in the rat

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12 December 2020

Effect of etoperidone on the depletion of brain 5-hydroxytryptamine and catecholamines induced respectively by p-chloromethamphetamine and 6-hydroxydopamine in rats

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12 December 2020

Distribution, metabolism, and irreversible binding of hexamethylmelamine in mice bearing ovarian carcinoma

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12 December 2020

1-m-Chlorophenylpiperazine is an active metabolite common to the psychotropic drugs trazodone, etoperidone and mepiprazole

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12 December 2020

Salicylate-aspirin interaction in the rat. Evidence that salicylate accumulating during aspirin administration may protect vascular prostacyclin from aspirin-induced inhibition

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12 December 2020

Differential salicylate-aspirin interaction on vascular prostacyclin and platelet thromboxane synthesis in patients undergoing saphenectomy

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12 December 2020

Trazodone, a central serotonin antagonist and agonist

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12 December 2020

Kinetics and metabolism of clobazam in animals and man

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12 December 2020

Disposition and metabolism of buspirone and its metabolite 1-(2-pyrimidinyl)-piperazine in the rat

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12 December 2020

Evidence for covalent binding of adriamycin to rat liver microsomal proteins

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12 December 2020

Differential effects of amphetamine, fenfluramine and norfenfluramine stereoisomers on the increase of striatum homovanillic acid in rats

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12 December 2020

Strand scission of DNA by bound adriamycin and daunorubicin in the presence of reducing agents

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12 December 2020

10.2165/00003088-198510030-00002

Identifiers

DOI

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Dimensions Publication ID

3 August 2017

1045012710

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