(Q34567906)

3 August 2017

1 reference

title

Methylated arsenicals: the implications of metabolism and carcinogenicity studies in rodents to human risk assessment (English)

1 reference

3 August 2017

Samuel M Cohen

1

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3 August 2017

Lora L Arnold

2

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3 August 2017

Michal Eldan

3

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3 August 2017

Ari S Lewis

4

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3 August 2017

Barbara D Beck

5

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3 August 2017

language of work or name

English

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publication date

1 February 2006

1 reference

Critical Reviews in Toxicology

3 August 2017

published in

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3 August 2017

volume

36

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3 August 2017

issue

2

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3 August 2017

page(s)

99-133

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Cytotoxic effect of three arsenic compounds in HeLa human tumor and bacterial cells.

3 August 2017

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21 January 2018

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Association of chromosomal alterations with arsenite-induced tumorigenicity of human HaCaT keratinocytes in nude mice

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Urothelial cytotoxicity and regeneration induced by dimethylarsinic acid in rats

21 January 2018

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Possible role of dimethylarsinous acid in dimethylarsinic acid-induced urothelial toxicity and regeneration in the rat.

21 January 2018

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The human relevance of information on carcinogenic modes of action: overview

21 January 2018

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Evaluating the human relevance of chemically induced animal tumors

21 January 2018

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Role of glutathione in reduction of arsenate and of gamma-glutamyltranspeptidase in disposition of arsenite in rats

21 January 2018

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Arsenic speciation in bile and urine following oral and intravenous exposure to inorganic and organic arsenics in rats

21 January 2018

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Arsenic speciation in the environment

21 January 2018

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Determination of trivalent methylated arsenicals in biological matrices.

21 January 2018

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Effects of arsenic on DNA damage and repair in human fetal lung fibroblasts

21 January 2018

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Uptake of inorganic and organic derivatives of arsenic associated with induced cytotoxic and genotoxic effects in Chinese hamster ovary (CHO) cells.

21 January 2018

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Arsenic uptake, cytotoxicity and detoxification studied in mammalian cells in culture.

21 January 2018

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Arsenic methylation is a process of detoxification through accelerated excretion

21 January 2018

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Inorganic arsenic methylation by rat tissue slices

21 January 2018

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https://api.crossref.org/works/10.1080%2F10408440500534230

Arsenic enhancement of skin neoplasia by chronic stimulation of growth factors

21 January 2018

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https://api.crossref.org/works/10.1080%2F10408440500534230

A perspective on current and future uses of alternative models for carcinogenicity testing

21 January 2018

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The glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase works as an arsenate reductase in human red blood cells and rat liver cytosol

21 January 2018

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Arsenic level in drinking water and mortality of lung cancer (Taiwan).

21 January 2018

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Coordination of altered DNA repair and damage pathways in arsenite-exposed keratinocytes

21 January 2018

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A new metabolic pathway of arsenite: arsenic-glutathione complexes are substrates for human arsenic methyltransferase Cyt19.

21 January 2018

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Enzymatic methylation of arsenic compounds: IV. In vitro and in vivo deficiency of the methylation of arsenite and monomethylarsonic acid in the guinea pig.

21 January 2018

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Dissimilatory arsenate reductase activity and arsenate-respiring bacteria in bovine rumen fluid, hamster feces, and the termite hindgut

21 January 2018

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Difference in uptake and toxicity of trivalent and pentavalent inorganic arsenic in rat heart microvessel endothelial cells

21 January 2018

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The accumulation and toxicity of methylated arsenicals in endothelial cells: important roles of thiol compounds

21 January 2018

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Arsenic toxicity is enzyme specific and its affects on ligation are not caused by the direct inhibition of DNA repair enzymes

21 January 2018

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Is the human carcinogen arsenic carcinogenic to laboratory animals?

21 January 2018

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Arsenic toxicity and potential mechanisms of action

21 January 2018

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Interaction of trivalent arsenicals with metallothionein

21 January 2018

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The MRP2/cMOAT transporter and arsenic-glutathione complex formation are required for biliary excretion of arsenic

21 January 2018

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Formation and urinary excretion of arsenic triglutathione and methylarsenic diglutathione

21 January 2018

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DNA damage induced in cultured human alveolar (L-132) cells by exposure to dimethylarsinic acid

21 January 2018

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Active arsenic species produced by GSH-dependent reduction of dimethylarsinic acid cause micronuclei formation in peripheral reticulocytes of mice

21 January 2018

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A concise review of the toxicity and carcinogenicity of dimethylarsinic acid

21 January 2018

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Recent advances in arsenic carcinogenesis: modes of action, animal model systems, and methylated arsenic metabolites

21 January 2018

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Oxidative stress as a possible mode of action for arsenic carcinogenesis

21 January 2018

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https://api.crossref.org/works/10.1080%2F10408440500534230

Methylated trivalent arsenicals as candidate ultimate genotoxic forms of arsenic: Induction of chromosomal mutations but not gene mutations

21 January 2018

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https://api.crossref.org/works/10.1080%2F10408440500534230

Effects of acute and chronic arsenic exposure of human-derived keratinocytes in an In Vitro human skin equivalent system: a novel model of human arsenicism

21 January 2018

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https://api.crossref.org/works/10.1080%2F10408440500534230

Stability of arsenic metabolites, arsenic triglutathione [As(GS)3] and methylarsenic diglutathione [CH3As(GS)2], in rat bile

21 January 2018

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https://api.crossref.org/works/10.1080%2F10408440500534230

Effect of trivalent and pentavalent arsenic in causing chromosome alterations in cultured Chinese hamster ovary (CHO) cells.

21 January 2018

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https://api.crossref.org/works/10.1080%2F10408440500534230

Speciation of key arsenic metabolic intermediates in human urine.

21 January 2018

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Drinking water arsenic in Utah: A cohort mortality study

21 January 2018

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Promotion of NCI-Black-Reiter male rat bladder carcinogenesis by dimethylarsinic acid an organic arsenic compound.

21 January 2018

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https://api.crossref.org/works/10.1080%2F10408440500534230

A novel S-adenosyl-L-methionine:arsenic(III) methyltransferase from rat liver cytosol

21 January 2018

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Speciation of dimethylarsinous acid and trimethylarsine oxide in urine from rats fed with dimethylarsinic acid and dimercaptopropane sulfonate.

21 January 2018

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Evidence of hemoglobin binding to arsenic as a basis for the accumulation of arsenic in rat blood

21 January 2018

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https://api.crossref.org/works/10.1080%2F10408440500534230

Arsenic and urinary bladder cell proliferation

21 January 2018

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Vesicular membrane permeability of monomethylarsonic and dimethylarsinic acids

21 January 2018

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Identification of dimethylarsinous and monomethylarsonous acids in human urine of the arsenic-affected areas in West Bengal, India.

21 January 2018

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Speciation of arsenic in biological samples

21 January 2018

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The role of the methylation in the detoxication of arsenate in the rabbit.

21 January 2018

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Methylated trivalent arsenic species are genotoxic

21 January 2018

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A framework for human relevance analysis of information on carcinogenic modes of action

21 January 2018

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Promotion of skin carcinogenesis by dimethylarsinic acid in keratin (K6)/ODC transgenic mice.

21 January 2018

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https://api.crossref.org/works/10.1080%2F10408440500534230

Arsenite induces delayed mutagenesis and transformation in human osteosarcoma cells at extremely low concentrations

21 January 2018

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https://api.crossref.org/works/10.1080%2F10408440500534230

Reduction of arsenate to arsenite by human erythrocyte lysate and rat liver cytosol - characterization of a glutathione- and NAD-dependent arsenate reduction linked to glycolysis

21 January 2018

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DNA damage induced by methylated trivalent arsenicals is mediated by reactive oxygen species

21 January 2018

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Promoting effects of monomethylarsonic acid, dimethylarsinic acid and trimethylarsine oxide on induction of rat liver preneoplastic glutathione S-transferase placental form positive foci: a possible reactive oxygen species mechanism

21 January 2018

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In vivo genotoxicity evaluation of dimethylarsinic acid in MutaMouse.

21 January 2018

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Public health. Worldwide occurrences of arsenic in ground water

21 January 2018

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Induction of centrosome injury, multipolar spindles and multipolar division in cultured V79 cells exposed to dimethylarsinic acid: role for microtubules in centrosome dynamics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440500534230

A trivalent dimethylarsenic compound, dimethylarsine iodide, induces cellular transformation, aneuploidy, centrosome abnormality and multipolar spindle formation in Syrian hamster embryo cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440500534230

Induction of DNA double strand breaks by arsenite: comparative studies with DNA breaks induced by X-rays

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440500534230

Determination of trivalent methylated arsenicals in rat urine by liquid chromatography-inductively coupled plasma mass spectrometry after solvent extraction

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440500534230

Monomethylarsonous acid (MMA(III)) is more toxic than arsenite in Chang human hepatocytes

21 January 2018

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https://api.crossref.org/works/10.1080%2F10408440500534230

Chronic arsenic toxicity in Bangladesh and West Bengal, India--a review and commentary.

21 January 2018

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Influence of sodium arsenite on the genotoxicity of potassium dichromate and ethyl methanesulfonate: studies with the wing spot test in Drosophila.

21 January 2018

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Mechanism of arsenic carcinogenesis: an integrated approach

21 January 2018

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Arsenite is a cocarcinogen with solar ultraviolet radiation for mouse skin: an animal model for arsenic carcinogenesis.

21 January 2018

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Implications of arsenic genotoxicity for dose response of carcinogenic effects

21 January 2018

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Expression of base excision DNA repair genes is a sensitive biomarker for in vivo detection of chemical-induced chronic oxidative stress: identification of the molecular source of radicals responsible for DNA damage by peroxisome proliferators

21 January 2018

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Inorganic and methylated arsenic compounds induce cell death in murine macrophages via different mechanisms

21 January 2018

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A major human arsenic metabolite, dimethylarsinic acid, requires reduced glutathione to induce apoptosis

21 January 2018

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Cellular glutathione prevents cytolethality of monomethylarsonic acid

21 January 2018

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https://api.crossref.org/works/10.1080%2F10408440500534230

Arsenic toxicity at low doses: epidemiological and mode of action considerations

21 January 2018

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Upregulation of glutathione-related genes and enzyme activities in cultured human cells by sublethal concentrations of inorganic arsenic.

21 January 2018

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Induction of oxidative DNA damage by arsenite and its trivalent and pentavalent methylated metabolites in cultured human cells and isolated DNA.

21 January 2018

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https://api.crossref.org/works/10.1080%2F10408440500534230

Lack of promoting effect due to oral administration of dimethylarsinic acid on rat lung carcinogenesis initiated with N-bis(2-hydroxypropyl)nitrosamine

21 January 2018

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Inorganic cadmium- and arsenite-induced malignant transformation of human bladder urothelial cells

21 January 2018

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Distribution and toxicity of monosodium methanearsonate following oral administration of the herbicide to dairy sheep and goats.

21 January 2018

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Induction of glutathione S-transferase placental form positive foci in liver and epithelial hyperplasia in urinary bladder, but no tumor development in male Fischer 344 rats treated with monomethylarsonic acid for 104 weeks

21 January 2018

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Arsenite causes DNA damage in keratinocytes via generation of hydroxyl radicals

21 January 2018

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https://api.crossref.org/works/10.1080%2F10408440500534230

Animal species difference in the uptake of dimethylarsinous acid (DMA(III)) by red blood cells

21 January 2018

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https://api.crossref.org/works/10.1080%2F10408440500534230

IPCS conceptual framework for evaluating a mode of action for chemical carcinogenesis

21 January 2018

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https://api.crossref.org/works/10.1080%2F10408440500534230

Cytotoxic and genotoxic effects of As, MMA, and DMA on leukocytes and stimulated human lymphocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440500534230

Arsenite disrupts mitosis and induces apoptosis in SV40-transformed human skin fibroblasts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440500534230

Comparative toxicity of trivalent and pentavalent inorganic and methylated arsenicals in rat and human cells

21 January 2018

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https://api.crossref.org/works/10.1080%2F10408440500534230

The role of biomethylation in toxicity and carcinogenicity of arsenic: a research update

21 January 2018

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https://api.crossref.org/works/10.1080%2F10408440500534230

Gene damage induced in human alveolar type II (L-132) cells by exposure to dimethylarsinic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440500534230

The cellular metabolism and systemic toxicity of arsenic

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440500534230

Elucidating the pathway for arsenic methylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440500534230

A chemical hypothesis for arsenic methylation in mammals

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440500534230

Inorganic arsenic compounds and methylated metabolites induce morphological transformation in two-stage BALB/c 3T3 cell assay and inhibit metabolic cooperation in V79 cell assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440500534230

Role of metabolism in arsenic toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440500534230

Differential effects of trivalent and pentavalent arsenicals on cell proliferation and cytokine secretion in normal human epidermal keratinocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440500534230

Dimethylarsinic acid induces 8-hydroxy-2'-deoxyguanosine formation in the kidney of NCI-Black-Reiter rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440500534230

Transplacental carcinogenicity of inorganic arsenic in the drinking water: induction of hepatic, ovarian, pulmonary, and adrenal tumors in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440500534230

Estrogen signaling in livers of male mice with hepatocellular carcinoma induced by exposure to arsenic in utero

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440500534230

Induction of tumors of the liver, lung, ovary and adrenal in adult mice after brief maternal gestational exposure to inorganic arsenic: promotional effects of postnatal phorbol ester exposure on hepatic and pulmonary, but not dermal cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440500534230

Active oxygen species are involved in the induction of micronuclei by arsenite in XRS-5 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440500534230

Arsenite induces oxidative DNA adducts and DNA-protein cross-links in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440500534230

A review of animal models for the study of arsenic carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440500534230

Arsenic speciation in urine from acute promyelocytic leukemia patients undergoing arsenic trioxide treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440500534230

Promotion of rat hepatocarcinogenesis by dimethylarsinic acid: association with elevated ornithine decarboxylase activity and formation of 8-hydroxydeoxyguanosine in the liver.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440500534230

Understanding arsenic carcinogenicity by the use of animal models

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440500534230

Endogenous reductants support the catalytic function of recombinant rat cyt19, an arsenic methyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440500534230

Glutathione modulates recombinant rat arsenic (+3 oxidation state) methyltransferase-catalyzed formation of trimethylarsine oxide and trimethylarsine

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440500534230

Carcinogenicity of dimethylarsinic acid in male F344 rats and genetic alterations in induced urinary bladder tumors

21 January 2018

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https://api.crossref.org/works/10.1080%2F10408440500534230

Effects of co-administration of antioxidants and arsenicals on the rat urinary bladder epithelium

21 January 2018

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https://api.crossref.org/works/10.1080%2F10408440500534230

Dose-response relation between arsenic concentration in well water and mortality from cancers and vascular diseases

21 January 2018

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https://api.crossref.org/works/10.1080%2F10408440500534230

Enhancement of chromosomal damage by arsenic: implications for mechanism

21 January 2018

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https://api.crossref.org/works/10.1080%2F10408440500534230

Possible carcinogenic potential of dimethylarsinic acid as assessed in rat in vivo models: a review

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440500534230

Induction of lung-specific DNA damage by metabolically methylated arsenics via the production of free radicals

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440500534230

Mutagenicity of dimethylated metabolites of inorganic arsenics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440500534230

Induction of DNA damage by dimethylarsine, a metabolite of inorganic arsenics, is for the major part likely due to its peroxyl radical

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440500534230

Crosslink formation between DNA and nuclear proteins by in vivo and in vitro exposure of cells to dimethylarsinic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440500534230

Involvement of preferential formation of apurinic/apyrimidinic sites in dimethylarsenic-induced DNA strand breaks and DNA-protein crosslinks in cultured alveolar epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440500534230

Exposure to dimethylarsinic acid, a main metabolite of inorganic arsenics, strongly promotes tumorigenesis initiated by 4-nitroquinoline 1-oxide in the lungs of mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440500534230

DNA single-strand breaks in L-132 cells resulting from inhibition of repair polymerization shortly after exposure to dimethylarsinic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440500534230

Oral administration of dimethylarsinic acid, a main metabolite of inorganic arsenic, in mice promotes skin tumorigenesis initiated by dimethylbenz(a)anthracene with or without ultraviolet B as a promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440500534230

Oral exposure of dimethylarsinic acid, a main metabolite of inorganic arsenics, in mice leads to an increase in 8-Oxo-2'-deoxyguanosine level, specifically in the target organs for arsenic carcinogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440500534230

Oxidative DNA damage following exposure to dimethylarsinous iodide: the formation of cis-thymine glycol

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440500534230

Enzymatic reduction of arsenic compounds in mammalian systems: the rate-limiting enzyme of rabbit liver arsenic biotransformation is MMA(V) reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440500534230

Enzymatic methylation of arsenic compounds. VII. Monomethylarsonous acid (MMAIII) is the substrate for MMA methyltransferase of rabbit liver and human hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440500534230

Sulfur-Containing Arsenical Mistaken for Dimethylarsinous Acid [DMA(III)] and Identified as a Natural Metabolite in Urine: Major Implications for Studies on Arsenic Metabolism and Toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440500534230

Incidence of Transitional Cell Carcinoma and Arsenic in Drinking Water: A Follow-up Study of 8,102 Residents in an Arseniasis-endemic Area in Northeastern Taiwan

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408440500534230

10.1080/10408440500534230

21 January 2018

Identifiers

DOI

1 reference

3 August 2017

1 reference