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The diversity of p53 mutations among human brain tumors and their functional consequences.
scientific article
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scholarly article
1 reference
stated in
Europe PubMed Central
PubMed ID
11900859
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11900859%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 December 2019
review article
1 reference
stated in
Europe PubMed Central
title
The diversity of p53 mutations among human brain tumors and their functional consequences
(English)
1 reference
stated in
Europe PubMed Central
PubMed ID
11900859
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11900859%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 December 2019
main subject
brain tumor
1 reference
based on heuristic
inferred from title
author
Bożena Kamińska-Kaczmarek
series ordinal
2
1 reference
stated in
Europe PubMed Central
PubMed ID
11900859
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11900859%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 December 2019
author name string
Agata Zupanska
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed ID
11900859
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11900859%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 December 2019
publication date
1 June 2002
1 reference
stated in
Europe PubMed Central
PubMed ID
11900859
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11900859%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 December 2019
published in
Neurochemistry International
1 reference
stated in
Europe PubMed Central
PubMed ID
11900859
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11900859%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 December 2019
volume
40
1 reference
stated in
Europe PubMed Central
PubMed ID
11900859
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11900859%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 December 2019
issue
7
1 reference
stated in
Europe PubMed Central
PubMed ID
11900859
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11900859%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 December 2019
page(s)
637-645
1 reference
stated in
Europe PubMed Central
PubMed ID
11900859
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11900859%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 December 2019
cites work
The p53 gene and its role in human brain tumors.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0197-0186%2801%2900114-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Analysis of JNK, Mdm2 and p14(ARF) contribution to the regulation of mutant p53 stability
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0197-0186%2801%2900114-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Activation of the ATM kinase by ionizing radiation and phosphorylation of p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0197-0186%2801%2900114-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cell cycle. Piecing together the p53 puzzle.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0197-0186%2801%2900114-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Functional analyses of a unique p53 germline mutant (Y236delta) associated with a familial brain tumor syndrome
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0197-0186%2801%2900114-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0197-0186%2801%2900114-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Activating mutations for transformation by p53 produce a gene product that forms an hsc70-p53 complex with an altered half-life
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0197-0186%2801%2900114-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Pharmacological rescue of mutant p53 conformation and function
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0197-0186%2801%2900114-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The p53 protein is an unusually shaped tetramer that binds directly to DNA.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0197-0186%2801%2900114-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
MEKK1/JNK signaling stabilizes and activates p53.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0197-0186%2801%2900114-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Conformational phenotype of p53 is linked to nuclear translocation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0197-0186%2801%2900114-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Protein synthesis required to anchor a mutant p53 protein which is temperature-sensitive for nuclear transport
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0197-0186%2801%2900114-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Demonstration of p53 protein and TP53 gene mutations in oligodendrogliomas.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0197-0186%2801%2900114-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Expression and functional activity of heat shock proteins in human glioblastoma multiforme
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0197-0186%2801%2900114-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Adenovirus-mediated wild-type p53 gene transfer and overexpression induces apoptosis of human glioma cells independent of endogenous p53 status.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0197-0186%2801%2900114-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Immunological evidence for the association of p53 with a heat shock protein, hsc70, in p53-plus-ras-transformed cell lines
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0197-0186%2801%2900114-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Allosteric activation of latent p53 tetramers
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0197-0186%2801%2900114-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Strategies for manipulating the p53 pathway in the treatment of human cancer.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0197-0186%2801%2900114-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Profile of gene expression regulated by induced p53: connection to the TGF-beta family
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0197-0186%2801%2900114-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Expression of human p53 requires synergistic activation of transcription from the p53 promoter by AP-1, NF-kappaB and Myc/Max
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0197-0186%2801%2900114-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Reduced latency but no increased brain tumor penetrance in mice with astrocyte specific expression of a human p53 mutant.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0197-0186%2801%2900114-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Germline p53 gene mutations in subsets of glioma patients.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0197-0186%2801%2900114-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Characterization of the human p53 gene
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0197-0186%2801%2900114-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Adenovirus-mediated p53 gene therapy for human gliomas
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0197-0186%2801%2900114-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Familial Brain Tumour Syndrome Associated with a p53 Germline Deletion of Codon 236
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0197-0186%2801%2900114-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cellular localization and cell cycle regulation by a temperature-sensitive p53 protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0197-0186%2801%2900114-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Negative growth regulation in a glioblastoma tumor cell line that conditionally expresses human wild-type p53.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0197-0186%2801%2900114-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cotranslation of activated mutant p53 with wild type drives the wild-type p53 protein into the mutant conformation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0197-0186%2801%2900114-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0197-0186%2801%2900114-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cyclosporin A, an immunosuppressive drug, induces programmed cell death in rat C6 glioma cells by a mechanism that involves the AP-1 transcription factor.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0197-0186%2801%2900114-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A correlative study of p53 protein alteration and p53 gene mutation in glioblastoma multiforme.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0197-0186%2801%2900114-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The DNA-binding domain of p53 contains the four conserved regions and the major mutation hot spots
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0197-0186%2801%2900114-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Effect of extracellular signal-regulated kinase on p53 accumulation in response to cisplatin
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0197-0186%2801%2900114-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A model for p53-induced apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0197-0186%2801%2900114-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Transcriptional regulation of the p53 tumor suppressor gene
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0197-0186%2801%2900114-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Human p53 oncogene contains one promoter upstream of exon 1 and a second, stronger promoter within intron 1.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0197-0186%2801%2900114-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Phosphorylation of serine 392 stabilizes the tetramer formation of tumor suppressor protein p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0197-0186%2801%2900114-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Effect of phosphorylation on tetramerization of the tumor suppressor protein p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0197-0186%2801%2900114-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
DNA damage activates p53 through a phosphorylation-acetylation cascade
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0197-0186%2801%2900114-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Adenovirus-mediated transfer of p53 and Fas ligand drastically enhances apoptosis in gliomas
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0197-0186%2801%2900114-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
DNA damage induces phosphorylation of the amino terminus of p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0197-0186%2801%2900114-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Amplification and overexpression of mdm2 gene in ependymomas
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0197-0186%2801%2900114-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0197-0186%2801%2900114-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mutations in serines 15 and 20 of human p53 impair its apoptotic activity.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0197-0186%2801%2900114-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p53 function and dysfunction
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0197-0186%2801%2900114-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Surfing the p53 network
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0197-0186%2801%2900114-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
NIH 3T3 cells malignantly transformed by mot-2 show inactivation and cytoplasmic sequestration of the p53 protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0197-0186%2801%2900114-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0197-0186%2801%2900114-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Wild-type p53-dependent etoposide-induced apoptosis mediated by caspase-3 activation in human glioma cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0197-0186%2801%2900114-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification and classification of p53-regulated genes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0197-0186%2801%2900114-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S0197-0186(01)00114-0
1 reference
stated in
Europe PubMed Central
PubMed ID
11900859
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11900859%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 December 2019
PubMed ID
11900859
1 reference
stated in
Europe PubMed Central
PubMed ID
11900859
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11900859%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 December 2019
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