(Q34572719)

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Profiling pathway-specific novel therapeutics in preclinical assessment for central nervous system atypical teratoid rhabdoid tumors (CNS ATRT): favorable activity of targeting EGFR- ErbB2 signaling with lapatinib

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scholarly article

1 reference

Europe PubMed Central

27 September 2017

Profiling pathway-specific novel therapeutics in preclinical assessment for central nervous system atypical teratoid rhabdoid tumors (CNS ATRT): favorable activity of targeting EGFR- ErbB2 signaling with lapatinib (English)

1 reference

Europe PubMed Central

27 September 2017

author name string

Anjali Singh

1

1 reference

Europe PubMed Central

27 September 2017

Xueqing Lun

2

1 reference

Europe PubMed Central

27 September 2017

Aarthi Jayanthan

3

1 reference

Europe PubMed Central

27 September 2017

Halah Obaid

4

1 reference

Europe PubMed Central

27 September 2017

Yibing Ruan

5

1 reference

Europe PubMed Central

27 September 2017

Douglas Strother

6

1 reference

Europe PubMed Central

27 September 2017

Susan N Chi

7

1 reference

Europe PubMed Central

27 September 2017

Amy Smith

8

1 reference

Europe PubMed Central

27 September 2017

Peter Forsyth

9

1 reference

Europe PubMed Central

27 September 2017

Aru Narendran

10

1 reference

Europe PubMed Central

27 September 2017

publication date

11 January 2013

1 reference

Europe PubMed Central

27 September 2017

Molecular Oncology

1 reference

Europe PubMed Central

27 September 2017

7

1 reference

Europe PubMed Central

27 September 2017

3

1 reference

Europe PubMed Central

27 September 2017

497-512

1 reference

Europe PubMed Central

27 September 2017

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5528492/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

High-resolution genomic analysis suggests the absence of recurrent genomic alterations other than SMARCB1 aberrations in atypical teratoid/rhabdoid tumors

1 reference

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Absence of oncogenic canonical pathway mutations in aggressive pediatric rhabdoid tumors.

1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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High throughput RNAi assay optimization using adherent cell cytometry

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The dual EGFR/HER2 inhibitor lapatinib synergistically enhances the antitumor activity of the histone deacetylase inhibitor panobinostat in colorectal cancer models.

1 reference

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Evasion mechanisms to Igf1r inhibition in rhabdomyosarcoma

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Atypical teratoid/rhabdoid tumor: short clinical description and insight into possible mechanism of the disease.

1 reference

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Synergistic interaction between trastuzumab and EGFR/HER-2 tyrosine kinase inhibitors in HER-2 positive breast cancer cells

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Epidermal growth factor receptor in triple-negative and basal-like breast cancer: promising clinical target or only a marker?

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Initial testing (stage 1) of lapatinib by the pediatric preclinical testing program

1 reference

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Delineation of molecular mechanisms of sensitivity to lapatinib in breast cancer cell lines using global gene expression profiles

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

https://pubmed.ncbi.nlm.nih.gov/23375777

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1016/J.MOLONC.2013.01.001

1 reference

Europe PubMed Central

27 September 2017

1 reference

Europe PubMed Central

27 September 2017

1 reference

Europe PubMed Central

27 September 2017

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