(Q34574036)

3 August 2017

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title

Recent advances in the pharmacogenomics of thiopurine methyltransferase (English)

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3 August 2017

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Coulthard SA

1

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3 August 2017

Hall AG

series ordinal

2

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3 August 2017

publication date

1 January 2001

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The Pharmacogenomics Journal

3 August 2017

published in

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3 August 2017

volume

1

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3 August 2017

issue

4

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3 August 2017

page(s)

254-261

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Role of postreplicative DNA mismatch repair in the cytotoxic action of thioguanine.

3 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500066

Altered mercaptopurine metabolism, toxic effects, and dosage requirement in a thiopurine methyltransferase-deficient child with acute lymphocytic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500066

Non-compliance with oral chemotherapy in childhood leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500066

Pharmacogenetics of acute azathioprine toxicity: relationship to thiopurine methyltransferase genetic polymorphism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500066

Thiopurine methyltransferase pharmacogenetics: human gene cloning and characterization of a common polymorphism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500066

Functional characterization of the human thiopurine S-methyltransferase (TPMT) gene promoter.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500066

Thiopurine methyltransferase polymorphic tandem repeat: genotype-phenotype correlation analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500066

Human erythrocyte thiopurine methyltransferase: radiochemical microassay and biochemical properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500066

A single point mutation leading to loss of catalytic activity in human thiopurine S-methyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500066

Enhanced proteolysis of thiopurine S-methyltransferase (TPMT) encoded by mutant alleles in humans (TPMT*3A, TPMT*2): mechanisms for the genetic polymorphism of TPMT activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500066

Genetic polymorphism of thiopurine methyltransferase and its clinical relevance for childhood acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500066

Human thiopurine methyltransferase pharmacogenetics: gene sequence polymorphisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500066

Isolation of a human thiopurine S-methyltransferase (TPMT) complementary DNA with a single nucleotide transition A719G (TPMT*3C) and its association with loss of TPMT protein and catalytic activity in humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500066

Molecular diagnosis of thiopurine S-methyltransferase deficiency: genetic basis for azathioprine and mercaptopurine intolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500066

Detection of known and new mutations in the thiopurine S-methyltransferase gene by single-strand conformation polymorphism analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500066

The use of denaturing high-pressure liquid chromatography for the detection of mutations in thiopurine methyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500066

Genotypic and phenotypic analysis of the polymorphic thiopurine S-methyltransferase gene (TPMT) in a European population.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500066

Azathioprine-induced myelosuppression in thiopurine methyltransferase deficient heart transplant recipient.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500066

Azathioprine-induced severe pancytopenia due to a homozygous two-point mutation of the thiopurine methyltransferase gene in a patient with juvenile HLA-B27-associated spondylarthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500066

Congenital thiopurine methyltransferase deficiency and 6-mercaptopurine toxicity during treatment for acute lymphoblastic leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500066

Severe 6-thioguanine-induced marrow aplasia in a child with acute lymphoblastic leukemia and inherited thiopurine methyltransferase deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500066

Genotypic analysis of thiopurine S-methyltransferase in patients with Crohn's disease and severe myelosuppression during azathioprine therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500066

High incidence of secondary brain tumours after radiotherapy and antimetabolites.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500066

Possible carcinogenic effect of 6-mercaptopurine on bone marrow stem cells: relation to thiopurine metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500066

Thiopurine methyltransferase activity and its relationship to the occurrence of rejection episodes in paediatric renal transplant recipients treated with azathioprine

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500066

A tellurite-resistance genetic determinant from phytopathogenic pseudomonads encodes a thiopurine methyltransferase: evidence of a widely-conserved family of methyltransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500066

Azathioprine in dermatology: a survey of current practice in the U.K.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500066

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500066

Genomic structure and multiple single-nucleotide polymorphisms (SNPs) of the thiopurine S-methyltransferase (TPMT) gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500066

Thiopurine methyltransferase alleles in British and Ghanaian populations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500066

Inhibition of phosphoribosyl pyrophosphate amidotransferase from Ehrlich ascites-tumour cells by thiopurine nucleotides

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500066

7 January 2021

Pharmacokinetics and metabolism of thiopurines in children with acute lymphoblastic leukemia receiving 6-thioguanine versus 6-mercaptopurine

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500066

7 January 2021

The importance of methylthio-IMP for methylmercaptopurine ribonucleoside (Me-MPR) cytotoxicity in Molt F4 human malignant T-lymphoblasts

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500066

7 January 2021

The cytotoxicity of thioguanine vs mercaptopurine in acute lymphoblastic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500066

7 January 2021

Segregation analysis of human red blood cell thiopurine methyltransferase activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500066

7 January 2021

A comparison of molecular and enzyme-based assays for the detection of thiopurine methyltransferase mutations

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500066

7 January 2021

Polymorphism of the thiopurine S-methyltransferase gene in African-Americans

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500066

7 January 2021

Ethnic differences in thiopurine methyltransferase pharmacogenetics: evidence for allele specificity in Caucasian and Kenyan individuals.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500066

7 January 2021

The frequency and distribution of thiopurine methyltransferase alleles in Caucasian and Asian populations

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https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500066

7 January 2021

Thiopurine methyltransferase genotype and the toxicity of azathioprine in Japanese

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500066

7 January 2021

High throughput detection of drug-metabolizing enzyme polymorphisms by allele-specific fluorogenic 5' nuclease chain reaction assay

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500066

7 January 2021

Thiopurine methyltransferase levels should be measured before commencing patients on azathioprine

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500066

7 January 2021

Pharmacokinetics, dose adjustments, and 6-mercaptopurine/methotrexate drug interactions in two patients with thiopurine methyltransferase deficiency

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500066

7 January 2021

Reduced thiopurine methyltransferase activity and development of side effects of azathioprine treatment in patients with rheumatoid arthritis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500066

7 January 2021

Preponderance of thiopurine S-methyltransferase deficiency and heterozygosity among patients intolerant to mercaptopurine or azathioprine

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500066

7 January 2021

Normal thiopurine methyltransferase levels do not eliminate 6-mercaptopurine or azathioprine toxicity in children with inflammatory bowel disease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500066

7 January 2021

Etoposide and antimetabolite pharmacology in patients who develop secondary acute myeloid leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500066

7 January 2021

Genetic variation in response to 6-mercaptopurine for childhood acute lymphoblastic leukaemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500066

7 January 2021

Identifiers

DOI

10.1038/SJ.TPJ.6500066

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Dimensions Publication ID

3 August 2017

1031895354

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