(Q34576408)

3 August 2017

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title

Haematopoietic cell-fate decisions, chromatin regulation and ikaros (English)

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3 August 2017

Katia Georgopoulos

1

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3 August 2017

publication date

1 March 2002

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Nature Reviews Immunology

3 August 2017

published in

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3 August 2017

volume

2

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3 August 2017

issue

3

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3 August 2017

page(s)

162-174

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Purification and characterization of mouse hematopoietic stem cells

3 August 2017

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Chromatin goes global

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HATs on and beyond chromatin

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Histone H4 isoforms acetylated at specific lysine residues define individual chromosomes and chromatin domains in Drosophila polytene nuclei

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Methylation of histone H3 at lysine 4 is highly conserved and correlates with transcriptionally active nuclei in Tetrahymena

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Methylation of histone H4 at arginine 3 facilitating transcriptional activation by nuclear hormone receptor

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Transitions in distinct histone H3 methylation patterns at the heterochromatin domain boundaries

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Correlation between histone lysine methylation and developmental changes at the chicken beta-globin locus

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Histone deacetylases associated with the mSin3 corepressor mediate mad transcriptional repression

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Signal-specific co-activator domain requirements for Pit-1 activation

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Transcriptional activators direct histone acetyltransferase complexes to nucleosomes

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Rb targets histone H3 methylation and HP1 to promoters

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Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain

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Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins

21 January 2018

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The bromodomain: a chromatin-targeting module?

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Structure and function of a human TAFII250 double bromodomain module

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The structural basis for the recognition of acetylated histone H4 by the bromodomain of histone acetyltransferase gcn5p

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Nonequivalent nuclear location of immunoglobulin alleles in B lymphocytes.

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ATP-dependent remodeling and acetylation as regulators of chromatin fluidity

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The "dark side" of chromatin remodeling: repressive effects on transcription

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Promoter targeting and chromatin remodeling by the SWI/SNF complex

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ATP-dependent chromatin remodeling activities.

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The many faces of chromatin remodeling: SWItching beyond transcription

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Stimulation of GAL4 derivative binding to nucleosomal DNA by the yeast SWI/SNF complex

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Binding of disparate transcriptional activators to nucleosomal DNA is inherently cooperative

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Ordered recruitment of transcription and chromatin remodeling factors to a cell cycle- and developmentally regulated promoter.

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Recruitment of the SWI/SNF chromatin remodeling complex by transcriptional activators

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Histone acetyltransferase complexes stabilize swi/snf binding to promoter nucleosomes.

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Early transcription and silencing of cytokine genes underlie polarization of T helper cell subsets.

21 January 2018

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Members of the Ikaros gene family are present in early representative vertebrates

21 January 2018

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Ikaros, an early lymphoid-specific transcription factor and a putative mediator for T cell commitment

21 January 2018

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Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation

21 January 2018

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Helios, a novel dimerization partner of Ikaros expressed in the earliest hematopoietic progenitors

21 January 2018

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Hematopoietic stem cells and lymphoid progenitors express different Ikaros isoforms, and Ikaros is localized to heterochromatin in immature lymphocytes.

21 January 2018

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Association of transcriptionally silent genes with Ikaros complexes at centromeric heterochromatin

21 January 2018

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Helios, a T cell-restricted Ikaros family member that quantitatively associates with Ikaros at centromeric heterochromatin

21 January 2018

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Aiolos regulates B cell activation and maturation to effector state

21 January 2018

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The Ikaros gene encodes a family of functionally diverse zinc finger DNA-binding proteins

21 January 2018

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The lymphoid transcription factor LyF-1 is encoded by specific, alternatively spliced mRNAs derived from the Ikaros gene

21 January 2018

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Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes

21 January 2018

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The Ikaros gene is required for the development of all lymphoid lineages

21 January 2018

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Defects in hemopoietic stem cell activity in Ikaros mutant mice

21 January 2018

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Selective defects in the development of the fetal and adult lymphoid system in mice with an Ikaros null mutation

21 January 2018

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Pre-T cell receptor (TCR) and TCR-controlled checkpoints in T cell differentiation are set by Ikaros

21 January 2018

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Eos: a novel member of the Ikaros gene family expressed predominantly in the developing nervous system

21 January 2018

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Targeting of Ikaros to pericentromeric heterochromatin by direct DNA binding

21 January 2018

1 reference

The dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activities

21 January 2018

1 reference

NURD, a novel complex with both ATP-dependent chromatin-remodeling and histone deacetylase activities

21 January 2018

1 reference

Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex

21 January 2018

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Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes

21 January 2018

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Ikaros interactions with CtBP reveal a repression mechanism that is independent of histone deacetylase activity

21 January 2018

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Purification and characterization of mSin3A-containing Brg1 and hBrm chromatin remodeling complexes

21 January 2018

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An ikaros-containing chromatin-remodeling complex in adult-type erythroid cells

21 January 2018

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Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene

21 January 2018

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DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development

21 January 2018

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Down-regulation of TDT transcription in CD4(+)CD8(+) thymocytes by Ikaros proteins in direct competition with an Ets activator

21 January 2018

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Ikaros, a lymphoid-cell-specific transcription factor, contributes to the leukemogenic phenotype of a mink cell focus-inducing murine leukemia virus

21 January 2018

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Enforced expression of the Ikaros isoform IK5 decreases the numbers of extrathymic intraepithelial lymphocytes and natural killer 1.1+ T cells.

21 January 2018

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dMi-2, a hunchback-interacting protein that functions in polycomb repression

21 January 2018

1 reference

Structure-function analysis of SUV39H1 reveals a dominant role in heterochromatin organization, chromosome segregation, and mitotic progression

21 January 2018

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Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability

21 January 2018

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Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities

21 January 2018

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Mutations in a new gene, encoding a zinc-finger protein, cause tricho-rhino-phalangeal syndrome type I

21 January 2018

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Transcriptional repression and developmental functions of the atypical vertebrate GATA protein TRPS1.

21 January 2018

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Clipping the carbon–carbon bond

21 January 2018

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Identification of a fetal hematopoietic precursor with B cell, T cell, and macrophage potential

21 January 2018

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Identification of very early lymphoid precursors in bone marrow and their regulation by estrogen

31 March 2020

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31 March 2020

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Dynamic repositioning of genes in the nucleus of lymphocytes preparing for cell division

31 March 2020

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Modulation of chromatin structure regulates cytokine gene expression during T cell differentiation

31 March 2020

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Unconventional potentiation of gene expression by Ikaros

31 March 2020

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Ikaros sets thresholds for T cell activation and regulates chromosome propagation

31 March 2020

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Binding of Ikaros to the lambda5 promoter silences transcription through a mechanism that does not require heterochromatin formation

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRI747

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3 August 2017

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