(Q34577669)

3 August 2017

5 references

12 September 2019

28 September 2019

12 October 2019

18 November 2019

19 November 2019

Simplifying complexity: genetically resculpting glycosphingolipid synthesis pathways in mice to reveal function (English)

1 reference

3 August 2017

1 reference

12 September 2019

1 reference

28 September 2019

1 reference

12 October 2019

1 reference

18 November 2019

1 reference

19 November 2019

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25351657%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

author name string

Maria Laura Allende

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25351657%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

publication date

29 October 2014

1 reference

25351657

3 August 2017

1 December 2014

5 references

12 September 2019

28 September 2019

12 October 2019

18 November 2019

19 November 2019

Glycoconjugate Journal

6 references

12 September 2019

28 September 2019

12 October 2019

18 November 2019

19 November 2019

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25351657%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

volume

31

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25351657%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

issue

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25351657%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

page(s)

613-622

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25351657%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1007/s10719-014-9563-5

7 June 2020

exact match

0 references

cites work

Normalizing glycosphingolipids restores function in CD4+ T cells from lupus patients.

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7 July 2018

1 reference

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Ganglioside GM3 depletion reverses impaired wound healing in diabetic mice by activating IGF-1 and insulin receptors.

7 July 2018

1 reference

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Sphingolipids and lysosomal pathologies

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4245496

Glycosphingolipids: synthesis and functions

7 July 2018

1 reference

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Mutations in B4GALNT1 (GM2 synthase) underlie a new disorder of ganglioside biosynthesis.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4245496

Ceramide synthesis in the epidermis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4245496

Sulfatides are required for renal adaptation to chronic metabolic acidosis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4245496

Neuronal expression of glucosylceramide synthase in central nervous system regulates body weight and energy homeostasis.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4245496

Glycosphingolipids are essential for intestinal endocytic function

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4245496

Role of sulfatide in normal and pathological cells and tissues

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4245496

Loss of GM3 synthase gene, but not sphingosine kinase 1, is protective against murine nephronophthisis-related polycystic kidney disease

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4245496

Functional roles of gangliosides in neurodevelopment: an overview of recent advances

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4245496

Gangliosides and the multiscale modulation of membrane structure

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4245496

Sphingolipid and glycosphingolipid metabolic pathways in the era of sphingolipidomics

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4245496

A view on sphingolipids and disease

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4245496

Multiple phenotypic changes in mice after knockout of the B3gnt5 gene, encoding Lc3 synthase--a key enzyme in lacto-neolacto ganglioside synthesis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4245496

Inhibition of glucosylceramide accumulation results in effective blockade of polycystic kidney disease in mouse models

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4245496

Lack of lacto/neolacto-glycolipids enhances the formation of glycolipid-enriched microdomains, facilitating B cell activation.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4245496

Brain gangliosides in axon-myelin stability and axon regeneration.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4245496

Absence of oligodendroglial glucosylceramide synthesis does not result in CNS myelin abnormalities or alter the dysmyelinating phenotype of CGT-deficient mice

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4245496

Liver-specific deficiency of serine palmitoyltransferase subunit 2 decreases plasma sphingomyelin and increases apolipoprotein E levels

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4245496

Mice lacking ganglioside GM3 synthase exhibit complete hearing loss due to selective degeneration of the organ of Corti

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4245496

The Lc3-synthase gene B3gnt5 is essential to pre-implantation development of the murine embryo

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4245496

The role and metabolism of sulfatide in the nervous system

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4245496

Normal development and function of invariant natural killer T cells in mice with isoglobotrihexosylceramide (iGb3) deficiency

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4245496

Epidermal growth factor receptor tyrosine kinase is modulated by GM3 interaction with N-linked GlcNAc termini of the receptor

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4245496

Gangliosides as components of lipid membrane domains.

7 July 2018

1 reference

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Epidermal sphingolipids: metabolism, function, and roles in skin disorders

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4245496

Targeted disruption of Gb3/CD77 synthase gene resulted in the complete deletion of globo-series glycosphingolipids and loss of sensitivity to verotoxins

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4245496

Cell-specific deletion of glucosylceramide synthase in brain leads to severe neural defects after birth.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4245496

Interruption of ganglioside synthesis produces central nervous system degeneration and altered axon-glial interactions

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4245496

Lysosomal glycosphingolipid recognition by NKT cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4245496

Infantile-onset symptomatic epilepsy syndrome caused by a homozygous loss-of-function mutation of GM3 synthase.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4245496

Enhanced insulin sensitivity in mice lacking ganglioside GM3.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4245496

"Multivalent" saccharides: development of new approaches for inhibiting the effects of glycosphingolipid-binding pathogens

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4245496

Combinatorial ganglioside biosynthesis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4245496

Paranodal junction formation and spermatogenesis require sulfoglycolipids

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4245496

Mice expressing only monosialoganglioside GM3 exhibit lethal audiogenic seizures.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4245496

cDNA cloning, genomic cloning, and tissue-specific regulation of mouse cerebroside sulfotransferase

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4245496

A vital role for glycosphingolipid synthesis during development and differentiation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4245496

Mice lacking complex gangliosides develop Wallerian degeneration and myelination defects

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4245496

Complex gangliosides are essential in spermatogenesis of mice: possible roles in the transport of testosterone

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4245496

Molecular cloning and expression of mouse ceramide glucosyltransferase.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4245496

Myelin-associated glycoprotein is a myelin signal that modulates the caliber of myelinated axons.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4245496

Functional breakdown of the lipid bilayer of the myelin membrane in central and peripheral nervous system by disrupted galactocerebroside synthesis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4245496

Mice with disrupted GM2/GD2 synthase gene lack complex gangliosides but exhibit only subtle defects in their nervous system

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4245496

Expression cloning of a cDNA for human ceramide glucosyltransferase that catalyzes the first glycosylation step of glycosphingolipid synthesis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4245496

Ceramide UDPgalactosyltransferase from myelinating rat brain: purification, cloning, and expression

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4245496

Early developmental expression of the gene encoding glucosylceramide synthase, the enzyme controlling the first committed step of glycosphingolipid synthesis.

7 July 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10719-014-9563-5

Conditional LoxP-flanked glucosylceramide synthase allele controlling glycosphingolipid synthesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10719-014-9563-5

Integrity and barrier function of the epidermis critically depend on glucosylceramide synthesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10719-014-9563-5

Differentiation of epidermal keratinocytes is dependent on glucosylceramide:ceramide processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10719-014-9563-5

Hepatic glycosphingolipid deficiency and liver function in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10719-014-9563-5

Beta4-galactosyltransferase-5 is a lactosylceramide synthase essential for mouse extra-embryonic development

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10719-014-9563-5

A functional role for complex gangliosides: motor deficits in GM2/GD2 synthase knockout mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10719-014-9563-5

Deficits in cognitive function and hippocampal plasticity in GM2/GD2 synthase knockout mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10719-014-9563-5

Novel class of glycosphingolipids involved in male fertility.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10719-014-9563-5

GD3 synthase gene knockout mice exhibit thermal hyperalgesia and mechanical allodynia but decreased response to formalin-induced prolonged noxious stimulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10719-014-9563-5

Reduced motor and sensory functions and emotional response in GM3-only mice: emergence from early stage of life and exacerbation with aging.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10719-014-9563-5

Myelination in the absence of galactocerebroside and sulfatide: normal structure with abnormal function and regional instability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10719-014-9563-5

Oligodendrocyte-specific ceramide galactosyltransferase (CGT) expression phenotypically rescues CGT-deficient mice and demonstrates that CGT activity does not limit brain galactosylceramide level

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10719-014-9563-5

Chemistry and functional distribution of sulfoglycolipids

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10719-014-9563-5

Nodal protrusions, increased Schmidt-Lanterman incisures, and paranodal disorganization are characteristic features of sulfatide-deficient peripheral nerves.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10719-014-9563-5

Kidney sulfatides in mouse models of inherited glycosphingolipid disorders: determination by nano-electrospray ionization tandem mass spectrometry.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10719-014-9563-5

Etiology of vision loss in ganglioside GM3 synthase deficiency.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10719-014-9563-5

Glycosphingolipid synthesis in cerebellar Purkinje neurons: roles in myelin formation and axonal homeostasis

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4245496

A myelin galactolipid, sulfatide, is essential for maintenance of ion channels on myelinated axon but not essential for initial cluster formation.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4245496

Lysosomal sulfoglycolipid storage in the kidneys of mice deficient for arylsulfatase A (ASA) and of double-knockout mice deficient for ASA and galactosylceramide synthase.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4245496

Galectin-3 drives glycosphingolipid-dependent biogenesis of clathrin-independent carriers

27 October 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10719-014-9563-5

Early lethality of beta-1,4-galactosyltransferase V-mutant mice by growth retardation

21 January 2018

1 reference

12 December 2020

b-series Ganglioside deficiency exhibits no definite changes in the neurogenesis and the sensitivity to Fas-mediated apoptosis but impairs regeneration of the lesioned hypoglossal nerve

1 reference

12 December 2020

Refractory skin injury in complex knock-out mice expressing only the GM3 ganglioside

1 reference

12 December 2020

Cloned beta 1,4 N-acetylgalactosaminyltransferase synthesizes GA2 as well as gangliosides GM2 and GD2. GM3 synthesis has priority over GA2 synthesis for utilization of lactosylceramide substrate in vivo

1 reference

12 December 2020

Sulfatide decrease in myelin influences formation of the paranodal axo-glial junction and conduction velocity in the sciatic nerve

1 reference

12 December 2020

Cutaneous dyspigmentation in patients with ganglioside GM3 synthase deficiency

1 reference

12 December 2020

10.1007/S10719-014-9563-5

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25351657%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

7 June 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25351657%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

25351657

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25351657%20AND%20SRC:MED&resulttype=core&format=json