(Q34580081)

3 August 2017

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title

The Warburg effect and its cancer therapeutic implications (English)

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3 August 2017

Zhao Chen

1

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3 August 2017

Weiqin Lu

series ordinal

2

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3 August 2017

Celia Garcia-Prieto

series ordinal

3

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3 August 2017

Peng Huang

series ordinal

4

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3 August 2017

1 June 2007

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Journal of Bioenergetics and Biomembranes

3 August 2017

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3 August 2017

39

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3 August 2017

267-274

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3 August 2017

3

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https://scigraph.springernature.com/pub.10.1007/s10863-007-9086-x

3 August 2017

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cites work

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

1 reference

12 December 2020

Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene

1 reference

12 December 2020

Increased mitochondrial biogenesis in primary leukemia cells: the role of endogenous nitric oxide and impact on sensitivity to fludarabine

1 reference

12 December 2020

On the Origin of Cancer Cells

1 reference

12 December 2020

Perturbational profiling of a cell-line model of tumorigenesis by using metabolic measurements

1 reference

12 December 2020

Mitochondrial bound type II hexokinase: a key player in the growth and survival of many cancers and an ideal prospect for therapeutic intervention

1 reference

12 December 2020

Contributions of glycolysis and oxidative phosphorylation to adenosine 5'-triphosphate production in AS-30D hepatoma cells.

1 reference

12 December 2020

Aerobic glycolysis by proliferating cells: a protective strategy against reactive oxygen species.

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12 December 2020

Detection of resistance to imatinib by metabolic profiling: clinical and drug development implications

1 reference

12 December 2020

Mitochondrial dysfunction is a common phenotype in aging and cancer

1 reference

12 December 2020

Expression of transketolase TKTL1 predicts colon and urothelial cancer patient survival: Warburg effect reinterpreted

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12 December 2020

Why do cancers have high aerobic glycolysis?

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12 December 2020

Enhancement of doxorubicin content by the antitumor drug lonidamine in resistant ehrlich ascites tumor cells through modulation of energy metabolism

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12 December 2020

Genes of glycolysis are ubiquitously overexpressed in 24 cancer classes

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12 December 2020

Effect of oncogene transformation of rat embryo cells on cellular oxygen consumption and glycolysis.

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12 December 2020

Characterization of the rat type III hexokinase gene promoter. A functional octamer 1 motif is critical for basal promoter activity

1 reference

12 December 2020

Glucose catabolism in cancer cells. Isolation, sequence, and activity of the promoter for type II hexokinase

1 reference

12 December 2020

HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia

1 reference

12 December 2020

New nuclear functions of the glycolytic protein, glyceraldehyde-3-phosphate dehydrogenase, in mammalian cells

1 reference

12 December 2020

Substrate oxidation and ATP supply in AS-30D hepatoma cells

1 reference

12 December 2020

Greater cell cycle inhibition and cytotoxicity induced by 2-deoxy-d-glucose in tumor cells treated under hypoxic vs aerobic conditions

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12 December 2020

Isozymes of mammalian hexokinase: structure, subcellular localization and metabolic function

1 reference

12 December 2020

Remarkably enhanced expression of the type II hexokinase in rat hepatoma cell line AH130.

1 reference

12 December 2020

Advanced cancers: eradication in all cases using 3-bromopyruvate therapy to deplete ATP.

1 reference

12 December 2020

Mitochondrial hexokinases, novel mediators of the antiapoptotic effects of growth factors and Akt.

1 reference

12 December 2020

Akt-Directed Glucose Metabolism Can Prevent Bax Conformation Change and Promote Growth Factor-Independent Survival

1 reference

12 December 2020

Glucose catabolism in the rabbit VX2 tumor model for liver cancer: characterization and targeting hexokinase

1 reference

12 December 2020

Mitochondrial mutations in cancer

1 reference

12 December 2020

TIGAR, a p53-inducible regulator of glycolysis and apoptosis

1 reference

12 December 2020

Glucose catabolism in African trypanosomes. Evidence that the terminal step is catalyzed by a pyruvate transporter capable of facilitating uptake of toxic analogs.

1 reference

12 December 2020

Hypoxia--a key regulatory factor in tumour growth

1 reference

12 December 2020

Synergistic effect of targeting mTOR by rapamycin and depleting ATP by inhibition of glycolysis in lymphoma and leukemia cells

1 reference

12 December 2020

Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance

1 reference

12 December 2020

Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase

1 reference

12 December 2020

Hexokinase-II expression in untreated oral squamous cell carcinoma: comparison with FDG PET imaging

1 reference

12 December 2020

Novel therapy for liver cancer: direct intraarterial injection of a potent inhibitor of ATP production.

1 reference

12 December 2020

Time to progression in metastatic breast cancer patients treated with epirubicin is not improved by the addition of either cisplatin or lonidamine: final results of a phase III study with a factorial design

1 reference

12 December 2020

Optimizing cancer radiotherapy with 2-deoxy-d-glucose dose escalation studies in patients with glioblastoma multiforme

1 reference

12 December 2020

Imatinib (STI571)-mediated changes in glucose metabolism in human leukemia BCR-ABL-positive cells

1 reference

12 December 2020

Mitochondrial DNA mutations in primary leukemia cells after chemotherapy: clinical significance and therapeutic implications.

1 reference

12 December 2020

Hypersensitization of tumor cells to glycolytic inhibitors

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12 December 2020

Inhibition of glycolysis in cancer cells: a novel strategy to overcome drug resistance associated with mitochondrial respiratory defect and hypoxia.

1 reference

12 December 2020

Elevated levels of glucose transport and transporter messenger RNA are induced by ras or src oncogenes.

1 reference

12 December 2020

Glycolysis inhibition for anticancer treatment

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12 December 2020

Mitochondrial tumour suppressors: a genetic and biochemical update

1 reference

12 December 2020

6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase and tumor cell glycolysis

1 reference

12 December 2020

2-deoxy-D-glucose increases the efficacy of adriamycin and paclitaxel in human osteosarcoma and non-small cell lung cancers in vivo

1 reference

12 December 2020

Efficacy of 2-halogen substituted D-glucose analogs in blocking glycolysis and killing "hypoxic tumor cells".

1 reference

12 December 2020

Lonidamine: efficacy and safety in clinical trials for the treatment of solid tumors

1 reference

12 December 2020

Oxythiamine and dehydroepiandrosterone induce a G1 phase cycle arrest in Ehrlich's tumor cells through inhibition of the pentose cycle

1 reference

12 December 2020

Effect of lonidamine on the cytotoxicity of four alkylating agents in vitro

1 reference

12 December 2020

Hypoxia increases tumor cell sensitivity to glycolytic inhibitors: a strategy for solid tumor therapy (Model C).

1 reference

12 December 2020

p53 regulates mitochondrial respiration

1 reference

12 December 2020

Glufosfamide administered using a 1-hour infusion given as first-line treatment for advanced pancreatic cancer. A phase II trial of the EORTC-new drug development group

1 reference

12 December 2020

Determining and understanding the control of glycolysis in fast-growth tumor cells. Flux control by an over-expressed but strongly product-inhibited hexokinase

1 reference

12 December 2020

Hexokinase II: cancer's double-edged sword acting as both facilitator and gatekeeper of malignancy when bound to mitochondria

1 reference

12 December 2020

The tumor suppressor cybL, a component of the respiratory chain, mediates apoptosis induction

1 reference

12 December 2020

Lonidamine, a selective inhibitor of aerobic glycolysis of murine tumor cells

1 reference

12 December 2020

Mutations in the transketolase-like gene TKTL1: clinical implications for neurodegenerative diseases, diabetes and cancer

1 reference

12 December 2020

A mutation in the SDHC gene of complex II increases oxidative stress, resulting in apoptosis and tumorigenesis.

1 reference

12 December 2020

Functional significance of mitochondrial bound hexokinase in tumor cell metabolism. Evidence for preferential phosphorylation of glucose by intramitochondrially generated ATP.

1 reference

12 December 2020

Glufosfamide administered by 1-hour infusion as a second-line treatment for advanced non-small cell lung cancer; a phase II trial of the EORTC-New Drug Development Group

1 reference

12 December 2020

Mitochondrial respiration defects in cancer cells cause activation of Akt survival pathway through a redox-mediated mechanism

1 reference

12 December 2020

10.1007/S10863-007-9086-X

Identifiers

DOI

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Dimensions Publication ID

3 August 2017

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