(Q34580854)

3 August 2017

title

The dichloroacetate dilemma: environmental hazard versus therapeutic goldmine--both or neither? (English)

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3 August 2017

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Peter W Stacpoole

1

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3 August 2017

publication date

4 October 2010

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Environmental Health Perspectives

3 August 2017

published in

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3 August 2017

volume

119

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3 August 2017

issue

2

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3 August 2017

page(s)

155-158

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Mitochondrion as a novel site of dichloroacetate biotransformation by glutathione transferase zeta 1.

3 August 2017

cites work

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7 July 2018

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Understanding the Warburg effect: the metabolic requirements of cell proliferation

7 July 2018

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Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer

7 July 2018

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The heme precursor delta-aminolevulinate blocks peripheral myelin formation

7 July 2018

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Role of dichloroacetate in the treatment of genetic mitochondrial diseases

7 July 2018

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Age-dependent kinetics and metabolism of dichloroacetate: possible relevance to toxicity

7 July 2018

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A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth

7 July 2018

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An abnormal mitochondrial-hypoxia inducible factor-1alpha-Kv channel pathway disrupts oxygen sensing and triggers pulmonary arterial hypertension in fawn hooded rats: similarities to human pulmonary arterial hypertension

7 July 2018

1 reference

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Controlled clinical trial of dichloroacetate for treatment of congenital lactic acidosis in children

7 July 2018

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Dichloroacetate causes toxic neuropathy in MELAS: a randomized, controlled clinical trial

7 July 2018

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Chronic treatment of mitochondrial disease patients with dichloroacetate

7 July 2018

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Dichloroacetate prevents and reverses pulmonary hypertension by inducing pulmonary artery smooth muscle cell apoptosis

7 July 2018

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Mice deficient in glutathione transferase zeta/maleylacetoacetate isomerase exhibit a range of pathological changes and elevated expression of alpha, mu, and pi class glutathione transferases

7 July 2018

1 reference

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Increased mortality odds ratio of male liver cancer in a community contaminated by chlorinated hydrocarbons in groundwater.

7 July 2018

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Recent advances in mechanisms regulating glucose oxidation at the level of the pyruvate dehydrogenase complex by PDKs

7 July 2018

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Low-dose pharmacokinetics and oral bioavailability of dichloroacetate in naive and GST-zeta-depleted rats

7 July 2018

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Dichloroacetate, a metabolic modulator, prevents and reverses chronic hypoxic pulmonary hypertension in rats: role of increased expression and activity of voltage-gated potassium channels

7 July 2018

1 reference

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Metabolism of trichloroethylene

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3040600

Inhibition of glutathione S-transferase zeta and tyrosine metabolism by dichloroacetate: a potential unifying mechanism for its altered biotransformation and toxicity

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3040600

Motor neuropathy in porphobilinogen deaminase-deficient mice imitates the peripheral neuropathy of human acute porphyria

7 July 2018

1 reference

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Clinical pharmacology and toxicology of dichloroacetate

7 July 2018

1 reference

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Evidence for existence of tissue-specific regulation of the mammalian pyruvate dehydrogenase complex

7 July 2018

1 reference

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Hereditary tyrosinemia and the heme biosynthetic pathway. Profound inhibition of delta-aminolevulinic acid dehydratase activity by succinylacetone

7 July 2018

1 reference

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The pharmacology of dichloroacetate

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3040600

A controlled clinical trial of dichloroacetate for treatment of lactic acidosis in adults. The Dichloroacetate-Lactic Acidosis Study Group

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3040600

Characterizing uncertainty and population variability in the toxicokinetics of trichloroethylene and metabolites in mice, rats, and humans using an updated database, physiologically based pharmacokinetic (PBPK) model, and Bayesian approach

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3040600

Development of an updated PBPK model for trichloroethylene and metabolites in mice, and its application to discern the role of oxidative metabolism in TCE-induced hepatomegaly

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3040600

Case-control study on renal cell cancer and occupational exposure to trichloroethylene. Part II: Epidemiological aspects.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3040600

Therapeutic potential of dichloroacetate for pyruvate dehydrogenase complex deficiency.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3040600

Effect of short-term drinking water exposure to dichloroacetate on its pharmacokinetics and oral bioavailability in human volunteers: a stable isotope study.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3040600

Inhibition and recovery of rat hepatic glutathione S-transferase zeta and alteration of tyrosine metabolism following dichloroacetate exposure and withdrawal.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3040600

Glutathione transferase zeta-catalyzed bioactivation of dichloroacetic acid: reaction of glyoxylate with amino acid nucleophiles

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3040600

Pharmacologic or genetic ablation of maleylacetoacetate isomerase increases levels of toxic tyrosine catabolites in rodents

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3040600

Renal cell cancer risk and occupational exposure to trichloroethylene: results of a consecutive case-control study in Arnsberg, Germany

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3040600

Alkylation and inactivation of human glutathione transferase zeta (hGSTZ1-1) by maleylacetone and fumarylacetone

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3040600

Dichloroacetate toxicokinetics and disruption of tyrosine catabolism in B6C3F1 mice: dose-response relationships and age as a modifying factor

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3040600

Inactivation of glutathione transferase zeta by dichloroacetic acid and other fluorine-lacking alpha-haloalkanoic acids.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3040600

The extent of dichloroacetate formation from trichloroethylene, chloral hydrate, trichloroacetate, and trichloroethanol in B6C3F1 mice.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3040600

Pharmacokinetics and metabolism of [14C]dichloroacetate in male Sprague-Dawley rats. Identification of glycine conjugates, including hippurate, as urinary metabolites of dichloroacetate.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3040600

Factors affecting species differences in the kinetics of metabolites of trichloroethylene.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3040600

Pharmacokinetics, metabolism and toxicology of dichloroacetate

27 October 2018

1 reference

12 December 2020

Polymorphism- and species-dependent inactivation of glutathione transferase zeta by dichloroacetate

1 reference

12 December 2020

Pharmacokinetics of dichloroacetate in adult patients with lactic acidosis

1 reference

12 December 2020

Characterization of nonvolatile aqueous chlorination products of humic substances

1 reference

12 December 2020

Human kinetics of orally and intravenously administered low-dose 1,2-(13)C-dichloroacetate

1 reference

12 December 2020

Conversion of trichloroacetic acid to dichloroacetic acid in biological samples

1 reference

12 December 2020

Identifiers

DOI

10.1289/EHP.1002554

1 reference

release_gnlhdshwabaphpd3scjrdohgcy

3 August 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/gnlhdshwabaphpd3scjrdohgcy

24 November 2022

mapped directly with Wikidata item

PMC publication ID

3040600

1 reference

3 August 2017

1 reference