(Q34580927)

3 August 2017

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title

The insulin gene in diabetes (English)

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3 August 2017

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Alberto Pugliese

1

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3 August 2017

Donatella Miceli

series ordinal

2

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3 August 2017

publication date

1 January 2002

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Diabetes - Metabolism: Research and Reviews

3 August 2017

published in

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3 August 2017

volume

18

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3 August 2017

issue

1

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3 August 2017

page(s)

13-25

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Glucose sensing in pancreatic beta-cells: a model for the study of other glucose-regulated cells in gut, pancreas, and hypothalamus

3 August 2017

cites work

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Recent advances in our understanding of insulin action and insulin resistance

21 January 2018

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IRS proteins and beta-cell function

21 January 2018

1 reference

Molecular and genetic bases for maturity onset diabetes of youth

21 January 2018

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The analysis of parental origin of alleles may detect susceptibility loci for complex disorders

21 January 2018

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Sequence of the human insulin gene

21 January 2018

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Characterization of the two nonallelic genes encoding mouse preproinsulin

21 January 2018

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Preproinsulin I and II mRNAs and insulin electron microscopic immunoreaction are present within the rat fetal nervous system

21 January 2018

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Insulin II gene expression in rat central nervous system.

21 January 2018

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Allele specific inactivation of insulin 1 and 2, in the mouse yolk sac, indicates imprinting

21 January 2018

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T-cell tolerance toward a transgenic beta-cell antigen and transcription of endogenous pancreatic genes in thymus

21 January 2018

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Pancreatic gene expression in rare cells of thymic medulla: evidence for functional contribution to T cell tolerance

21 January 2018

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Peripheral-antigen-expressing cells in thymic medulla: factors in self-tolerance and autoimmunity

21 January 2018

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Self-antigen-presenting cells expressing diabetes-associated autoantigens exist in both thymus and peripheral lymphoid organs

21 January 2018

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Regulation of insulin gene transcription

21 January 2018

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Developmental biology of the pancreas.

21 January 2018

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Glucose stimulates translocation of the homeodomain transcription factor PDX1 from the cytoplasm to the nucleus in pancreatic beta-cells

21 January 2018

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The homeodomain of PDX-1 mediates multiple protein-protein interactions in the formation of a transcriptional activation complex on the insulin promoter

21 January 2018

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Transcription factors contributing to the pancreatic beta-cell phenotype

21 January 2018

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Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence

21 January 2018

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Insulin promoter factor-1 gene mutation linked to early-onset type 2 diabetes mellitus directs expression of a dominant negative isoprotein

21 January 2018

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Impaired insulin secretion and increased insulin sensitivity in familial maturity-onset diabetes of the young 4 (insulin promoter factor 1 gene).

21 January 2018

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Defective mutations in the insulin promoter factor-1 (IPF-1) gene in late-onset type 2 diabetes mellitus

21 January 2018

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Missense mutations in the insulin promoter factor-1 gene predispose to type 2 diabetes

21 January 2018

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Functional consequences of mutations in the MODY4 gene (IPF1) and coexistence with MODY3 mutations

21 January 2018

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Mutations in NEUROD1 are associated with the development of type 2 diabetes mellitus

21 January 2018

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Phenotypic characteristics of early-onset autosomal-dominant type 2 diabetes unlinked to known maturity-onset diabetes of the young (MODY) genes.

21 January 2018

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NeuroD/BETA2 gene variability and diabetes: no associations to late-onset type 2 diabetes but an A45 allele may represent a susceptibility marker for type 1 diabetes among Danes. Danish Study Group of Diabetes in Childhood, and the Danish IDDM Epide

21 January 2018

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Regulation of the pancreatic islet-specific gene BETA2 (neuroD) by neurogenin 3.

21 January 2018

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Regulation of the pancreatic pro-endocrine gene neurogenin3.

21 January 2018

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Polymorphisms in the neurogenin 3 gene (NEUROG) and their relation to altered insulin secretion and diabetes in the Danish Caucasian population

21 January 2018

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The highly polymorphic region near the human insulin gene is composed of simple tandemly repeating sequences

21 January 2018

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The minisatellite in the diabetes susceptibility locus IDDM2 regulates insulin transcription.

21 January 2018

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Regulation of insulin gene expression by the IDDM associated, insulin locus haplotype

21 January 2018

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Analysis of a 1963-bp polymorphic region flanking the human insulin gene

21 January 2018

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The human insulin gene linked polymorphic region exhibits an altered DNA structure

21 January 2018

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Unusual DNA structure of the diabetes susceptibility locus IDDM2 and its effect on transcription by the insulin promoter factor Pur-1/MAZ.

21 January 2018

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Insulin-IGF2 region on chromosome 11p encodes a gene implicated in HLA-DR4-dependent diabetes susceptibility

21 January 2018

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Insulin gene region-encoded susceptibility to type 1 diabetes is not restricted to HLA-DR4-positive individuals

21 January 2018

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Human type 1 diabetes and the insulin gene: principles of mapping polygenes

21 January 2018

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IDDM2-VNTR-encoded susceptibility to type 1 diabetes: dominant protection and parental transmission of alleles of the insulin gene-linked minisatellite locus

21 January 2018

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Variation in the sequence and modification state of the human insulin gene flanking regions

21 January 2018

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The search for IDDM susceptibility genes: the next generation

21 January 2018

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Paternally transmitted IDDM2 influences diabetes susceptibility despite biallelic expression of the insulin gene in human pancreas.

21 January 2018

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Tissue- and developmental stage-specific imprinting of the mouse proinsulin gene, Ins2.

21 January 2018

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Paramutation and related allelic interactions

21 January 2018

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Imprinting at the mouse Ins2 locus: evidence for cis- and trans-allelic interactions.

21 January 2018

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Early expression of antiinsulin autoantibodies of humans and the NOD mouse: evidence for early determination of subsequent diabetes

21 January 2018

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A disease-associated cellular immune response in type 1 diabetics to an immunodominant epitope of insulin

21 January 2018

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Diabetogenic T-cell clones

21 January 2018

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Identification of an MHC class I-restricted autoantigen in type 1 diabetes by screening an organ-specific cDNA library.

21 January 2018

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The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes.

21 January 2018

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Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus.

21 January 2018

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Aberrant expression of tissue-specific proteins in the thymus: a hypothesis for the development of central tolerance

21 January 2018

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Evidence for a differential avidity model of T cell selection in the thymus

21 January 2018

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Intrathymic and extrathymic clonal deletion of T cells

21 January 2018

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Intravenous injection of soluble antigen induces thymic and peripheral T-cells apoptosis.

21 January 2018

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An acetylcholine receptor alpha subunit promoter confers intrathymic expression in transgenic mice. Implications for tolerance of a transgenic self-antigen and for autoreactivity in myasthenia gravis

21 January 2018

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Deregulation of both imprinted and expressed alleles of the insulin-like growth factor 2 gene during beta-cell tumorigenesis

21 January 2018

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The intrathymic expression of insulin-related genes: implications for pathophysiology and prevention of Type 1 diabetes

21 January 2018

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Thymic expression of insulin-related genes in an animal model of autoimmune type 1 diabetes.

21 January 2018

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BB rat thymocytes cultured in the presence of islets lose their ability to transfer autoimmune diabetes

21 January 2018

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beta-cell dysfunction and failure in type 2 diabetes: potential mechanisms.

21 January 2018

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Polymorphism in the 5′ Flanking Region of the Human Insulin Gene: A Genetic Marker for Non-Insulin-Dependent Diabetes

21 January 2018

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Lack of association of the polymorphic locus in the 5'-flanking region of the human insulin gene and diabetes in American blacks

21 January 2018

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Insulin gene in diabetes. Analysis through RFLP.

21 January 2018

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The insulin gene VNTR, type 2 diabetes and birth weight

21 January 2018

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Minisatellites: mutability and genome architecture.

21 January 2018

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The insulin gene VNTR is associated with fasting insulin levels and development of juvenile obesity.

21 January 2018

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Associations of IGF2 ApaI RFLP and INS VNTR class I allele size with obesity

21 January 2018

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Central obesity and hyperinsulinaemia in women are associated with polymorphism in the 5' flanking region of the human insulin gene

21 January 2018

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Polymorphism at the 5' end flanking region of the insulin gene is associated with reduced insulin secretion in healthy individuals.

21 January 2018

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Fetal and infant growth and impaired glucose tolerance at age 64.

21 January 2018

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Association of the INS VNTR with size at birth. ALSPAC Study Team. Avon Longitudinal Study of Pregnancy and Childhood

21 January 2018

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The INS 5' variable number of tandem repeats is associated with IGF2 expression in humans

21 January 2018

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Imprinted and Genotype-specific Expression of Genes at theIDDM2Locus in Pancreas and Leucocytes

21 January 2018

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Insulin VNTR allele-specific effect in type 1 diabetes depends on identity of untransmitted paternal allele

21 January 2018

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Autoimmune diabetes as a consequence of locally produced interleukin-2

21 January 2018

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A functional analysis of the role of IGF2 in IDDM2-encoded susceptibility to type 1 diabetes

21 January 2018

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No evidence of linkage or diabetes-associated mutations in the transcription factors BETA2/NEUROD1 and PAX4 in Type II diabetes in France

21 January 2018

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Susceptibility to human type 1 diabetes at IDDM2 is determined by tandem repeat variation at the insulin gene minisatellite locus

21 January 2018

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Evidence that insulin is imprinted in the human yolk sac

21 January 2018

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7 January 2021

Evidence for biosynthesis of preproinsulin in gut of rat

1 reference

7 January 2021

Pancreatic hormone expression in the murine thymus: localization in dendritic cells and macrophages

1 reference

7 January 2021

Mutations in the insulin promoter factor-1 gene in late-onset type 2 diabetes mellitus

1 reference

7 January 2021

Association of polymorphism in the NeuroD/BETA2 gene with type 1 diabetes in the Japanese

1 reference

7 January 2021

A consensus repeat sequence from the human insulin gene linked polymorphic region adopts multiple quadriplex DNA structures in vitro

1 reference

7 January 2021

A Polymorphic Locus Near the Human Insulin Gene Is Associated with Insulin-dependent Diabetes Melliitus

1 reference

7 January 2021

Localization of a type I diabetes susceptibility locus to the variable tandem repeat region flanking the insulin gene

1 reference

7 January 2021

Insulin gene region-encoded susceptibility to IDDM maps upstream of the insulin gene

1 reference

7 January 2021

The insulin gene region and susceptibility to insulin-dependent diabetes mellitus in four races; new insights from Afro-Caribbean race-specific haplotypes

1 reference

7 January 2021

Diabetes susceptibility at IDDM2 cannot be positively mapped to the VNTR locus of the insulin gene

1 reference

7 January 2021

The paternally inherited insulin gene B allele (1,428 FokI site) confers protection from insulin-dependent diabetes in families

1 reference

7 January 2021

Concordance for type 1 diabetes in identical twins is affected by insulin genotype

1 reference

7 January 2021

Allele diversity and germline mutation at the insulin minisatellite

1 reference

7 January 2021

Influence of allele lineage on the role of the insulin minisatellite in susceptibility to type 1 diabetes

1 reference

7 January 2021

Parental genomic imprinting of the human IGF2 gene

1 reference

7 January 2021

Anomalous behaviour of the 5' insulin gene polymorphism allele 814: lack of association with Type I diabetes in Basques. GEPV-N Group. Basque-Navarre Endocrinology and Paediatrics

1 reference

7 January 2021

Homologous association of oppositely imprinted chromosomal domains

1 reference

7 January 2021

Insulin Antibodies in Insulin-Dependent Diabetics Before Insulin Treatment

1 reference

7 January 2021

Concentration of insulin autoantibodies at onset of type I diabetes. Inverse log-linear correlation with age

1 reference

7 January 2021

Competitive insulin autoantibody assay. Prospective evaluation of subjects at high risk for development of type I diabetes mellitus

1 reference

7 January 2021

Effects of free fatty acids and glucose on splanchnic insulin dynamics

1 reference

7 January 2021

Cellular immune responses against proinsulin: no evidence for enhanced reactivity in individuals with IDDM

1 reference

7 January 2021

Intrathymic expression of genes involved in organ specific autoimmune disease

1 reference

7 January 2021

Positive and negative thymocyte selection induced by different concentrations of a single peptide

1 reference

7 January 2021

Escape of thymocytes and mature T cells from clonal deletion due to limiting tolerogen expression levels

1 reference

7 January 2021

Transgenic expression of mouse proinsulin II prevents diabetes in nonobese diabetic mice

1 reference

7 January 2021

Evidence of IgG autoantibodies against human proinsulin in patients with IDDM before insulin treatment

1 reference

7 January 2021

Characterization of insulin autoantibodies in relatives of patients with type I diabetes

1 reference

7 January 2021

Autoantibodies to insulin and to proinsulin in type 1 diabetic patients and in at-risk probands differentiate only little between both antigens

1 reference

7 January 2021

Effect of polymorphism in the insulin gene region on IDDM susceptibility and insulin secretion. The Childhood Diabetes in Finland (DiMe) Study Group

1 reference

7 January 2021

GAD65 and insulin B chain peptide (9-23) are not primary autoantigens in the type 1 diabetes syndrome of the BB rat

1 reference

7 January 2021

Oral insulin does not prevent insulin-dependent diabetes mellitus in BB rats

1 reference

7 January 2021

Polymorphism in the 5′-Flanking Region of the Human Insulin Gene and Its Possible Relation to Type 2 Diabetes

1 reference

7 January 2021

Restriction Fragment Length Polymorphism of the Insulin Gene in Diabetes Mellitus

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7 January 2021

Polymorphisms in the 5′-Flanking Region of the Insulin Gene and Non-Insulin-Dependent Diabetes

1 reference

7 January 2021

Islet beta-cell function and polymorphism in the 5'-flanking region of the human insulin gene

1 reference

7 January 2021

High frequency of class 3 allele in the human insulin gene in Japanese type 2 (non-insulin-dependent) diabetic patients with a family history of diabetes

1 reference

7 January 2021

Allelic variants at insulin-receptor and insulin gene loci and susceptibility to NIDDM in Welsh population

1 reference

7 January 2021

Analysis of parent-offspring trios provides evidence for linkage and association between the insulin gene and type 2 diabetes mediated exclusively through paternally transmitted class III variable number tandem repeat alleles

1 reference

7 January 2021

INS VNTR allelic variation and dynamic insulin secretion in healthy adult non-diabetic Caucasian subjects

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7 January 2021

Linkage and association of insulin gene VNTR regulatory polymorphism with polycystic ovary syndrome

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7 January 2021

Identifiers

DOI

10.1002/DMRR.261

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3 August 2017

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