(Q34581581)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11922957%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

review article

1 reference

title

Physiologically-based pharmacokinetic simulation modelling (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11922957%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

1 reference

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11922957%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

author name string

George M Grass

series ordinal

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11922957%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

language of work or name

English

0 references

publication date

1 March 2002

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11922957%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

number of pages

19

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Advanced Drug Delivery Reviews

inferred from page(s)

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11922957%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

volume

54

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11922957%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

page(s)

433-451

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11922957%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

issue

3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11922957%20AND%20SRC:MED&resulttype=core&format=json

Drug discovery: a historical perspective

8 December 2019

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7 January 2021

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7 January 2021

General principles in the characterization and use of model systems for biopharmaceutical studies.

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7 January 2021

Optimizing the science of drug development: opportunities for better candidate selection and accelerated evaluation in humans

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7 January 2021

Opportunities for integration of pharmacokinetics, pharmacodynamics, and toxicokinetics in rational drug development

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7 January 2021

How many leads from HTS?

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7 January 2021

Optimizing the science of drug development: opportunities for better candidate selection and accelerated evaluation in humans

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7 January 2021

Present and future in vitro approaches for drug metabolism.

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7 January 2021

Progress in predicting human ADME parameters in silico

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7 January 2021

Model of disposition of drugs administered into the human nasal cavity.

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7 January 2021

Mathematical modeling of deposition and disposition of drugs administered via the nose.

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7 January 2021

Theoretical pharmacokinetic and pharmacodynamic simulations of drug delivery mediated by blood--brain barrier transporters

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7 January 2021

Simulation of clinical trials

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7 January 2021

Modelling and simulation in clinical drug development

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7 January 2021

Review of theoretical passive drug absorption models: historical background, recent developments and limitations

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7 January 2021

Modelling during drug development

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7 January 2021

Linear correlation of the fraction of oral dose absorbed of 64 drugs between humans and rats

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7 January 2021

Evaluation of using dog as an animal model to study the fraction of oral dose absorbed of 43 drugs in humans.

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7 January 2021

Correlation of unbound plasma clearances of fifteen extensively metabolized drugs between humans and rats

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7 January 2021

Epithelial transport of drugs in cell culture. I: A model for studying the passive diffusion of drugs over intestinal absorptive (Caco-2) cells

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7 January 2021

Estimating human oral fraction dose absorbed: a correlation using rat intestinal membrane permeability for passive and carrier-mediated compounds.

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7 January 2021

Evaluation of the performance of controlled release dosage forms of ticlopidine using in vitro intestinal permeability and computer simulations

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7 January 2021

Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells

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7 January 2021

Correlation between oral drug absorption in humans, and apparent drug permeability in TC-7 cells, a human epithelial intestinal cell line: comparison with the parental Caco-2 cell line

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7 January 2021

Predicting fraction dose absorbed in humans using a macroscopic mass balance approach

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7 January 2021

Comparison of HT29-18-C1 and Caco-2 cell lines as models for studying intestinal paracellular drug absorption.

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7 January 2021

Comparison of intestinal permeabilities determined in multiple in vitro and in situ models: relationship to absorption in humans

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7 January 2021

Use of immobilized artificial membrane chromatography for drug transport applications

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7 January 2021

Correlation of drug absorption with molecular surface properties

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7 January 2021

Evaluation of dynamic polar molecular surface area as predictor of drug absorption: comparison with other computational and experimental predictors

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7 January 2021

Polar molecular surface properties predict the intestinal absorption of drugs in humans.

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7 January 2021

Polar molecular surface as a dominating determinant for oral absorption and brain penetration of drugs

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7 January 2021

Prediction of polar surface area and drug transport processes using simple parameters and PLS statistics

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7 January 2021

Rapid calculation of polar molecular surface area and its application to the prediction of transport phenomena. 1. Prediction of intestinal absorption

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7 January 2021

Development of predictive pharmacokinetic simulation models for drug discovery

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7 January 2021

Caco-2 cell permeability vs human gastrointestinal absorption: QSPR analysis.

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7 January 2021

Combining in vitro and in vivo pharmacokinetic data for prediction of hepatic drug clearance in humans by artificial neural networks and multivariate statistical techniques

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7 January 2021

QSAR model for drug human oral bioavailability.

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7 January 2021

Prediction of human intestinal absorption of drug compounds from molecular structure.

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7 January 2021

Analysis of drug permeation across Caco-2 monolayer: implication for predicting in vivo drug absorption.

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7 January 2021

Optimized conditions for prediction of intestinal drug permeability using Caco-2 cells

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7 January 2021

A compartmental absorption and transit model for estimating oral drug absorption.

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7 January 2021

An integrated model for determining causes of poor oral drug absorption.

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7 January 2021

Prediction of hepatic clearance from microsomes, hepatocytes, and liver slices

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7 January 2021

Influence of First-Pass Effect on Availability of Drugs on Oral Administration

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7 January 2021

Differentiation of absorption and first-pass gut and hepatic metabolism in humans: studies with cyclosporine

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7 January 2021

Prediction of hepatic metabolic clearance: comparison and assessment of prediction models

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7 January 2021

Physiologic modeling of cyclosporin kinetics in rat and man.

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7 January 2021

A physiologically based pharmacokinetic model incorporating dispersion principles to describe solute distribution in the perfused rat hindlimb preparation.

1 reference

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7 January 2021

A biologically-based algorithm for predicting human tissue: blood partition coefficients of organic chemicals.

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7 January 2021

An approach for incorporating tissue composition data into physiologically based pharmacokinetic models

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7 January 2021

An algorithm for predicting tissue: blood partition coefficients of organic chemicals from n-octanol: water partition coefficient data

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7 January 2021

Prediction of adipose tissue: plasma partition coefficients for structurally unrelated drugs

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7 January 2021

A priori prediction of tissue:plasma partition coefficients of drugs to facilitate the use of physiologically-based pharmacokinetic models in drug discovery.

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7 January 2021

Optimal experimental design for precise estimation of the parameters of the axial dispersion model of hepatic elimination

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7 January 2021

Effect of altered tissue binding on the disposition of barbital in the isolated perfused rat liver: application of the axial dispersion model

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7 January 2021

A Two-compartment Dispersion Model Describes the Hepatic Outflow Profile of Diclofenac in the Presence of its Binding Protein

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7 January 2021

Physiologic models of hepatic drug clearance: influence of altered protein binding on the elimination of diclofenac in the isolated perfused rat liver

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7 January 2021

Theoretical calculation and prediction of Caco-2 cell permeability using MolSurf parametrization and PLS statistics

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7 January 2021

Improved prediction of in vivo peroral absorption from in vitro intestinal permeability using an internal standard to control for intra- and inter-rat variability

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7 January 2021

Permeability characteristics of various intestinal regions of rabbit, dog, and monkey

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7 January 2021

A correlation of permeabilities for passively transported compounds in monkey and rabbit jejunum.

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7 January 2021

VolSurf: a new tool for the pharmacokinetic optimization of lead compounds

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7 January 2021

Correlation of human jejunal permeability (in vivo) of drugs with experimentally and theoretically derived parameters. A multivariate data analysis approach

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7 January 2021

On the recognition of mammalian microsomal cytochrome P450 substrates and their characteristics: towards the prediction of human p450 substrate specificity and metabolism

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7 January 2021

Whole-cell simulation: a grand challenge of the 21st century

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7 January 2021

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7 January 2021

E-CELL: software environment for whole-cell simulation

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7 January 2021

A general computational framework for modeling cellular structure and function

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7 January 2021

Physiological modeling with virtual cell framework

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7 January 2021

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900013-3

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7 January 2021

Biological simulations in drug discovery

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7 January 2021

Simulation of toluene kinetics in the rat by a physiologically based pharmacokinetic model with application of biotransformation parameters derived independently in vitro and in vivo.

1 reference

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7 January 2021

Pharmacogenetics of the human drug-transporter gene MDR1: impact of polymorphisms on pharmacotherapy

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7 January 2021

Kinetic and biochemical analysis of carrier-mediated efflux of drugs through the blood-brain and blood-cerebrospinal fluid barriers: importance in the drug delivery to the brain

1 reference

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7 January 2021

Substrate recognition by P-glycoprotein and the multidrug resistance-associated protein MRP1: a comparison.

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7 January 2021

RETRACTED: Structure of MsbA from E. coli: a homolog of the multidrug resistance ATP binding cassette (ABC) transporters

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7 January 2021

Potential role of P-glycoprotein in affecting hepatic metabolism of drugs

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7 January 2021

10.1016/S0169-409X(02)00013-3

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11922957%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

1 reference