(Q34582990)

3 August 2017

1 reference

title

The neurobiology of bipolar disorder: focus on signal transduction pathways and the regulation of gene expression (English)

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3 August 2017

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Yarema Bezchlibnyk

1

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3 August 2017

L Trevor Young

series ordinal

2

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3 August 2017

language of work or name

English

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publication date

1 March 2002

1 reference

Canadian Journal of Psychiatry

3 August 2017

published in

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3 August 2017

volume

47

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3 August 2017

issue

2

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3 August 2017

page(s)

135-148

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Signal sorting and amplification through G protein-coupled receptors

3 August 2017

cites work

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Blunted beta-adrenergic responsivity of peripheral blood mononuclear cells in endogenous depression. Isoproterenol dose-response studies

21 January 2018

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Ziskind-Somerfeld Research Award. Protein kinase C signaling in the brain: molecular transduction of mood stabilization in the treatment of manic-depressive illness

21 January 2018

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Receptor-to-effector signaling through G proteins: roles for beta gamma dimers as well as alpha subunits

21 January 2018

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Effects of lithium on second messenger systems in the brain

21 January 2018

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Lithium inhibits adrenergic and cholinergic increases in GTP binding in rat cortex

21 January 2018

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The mechanisms of action of lithium. II. Effects on adenylate cyclase activity and beta-adrenergic receptor binding in normal subjects

21 January 2018

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Postmortem cerebral cortex Gs alpha-subunit levels are elevated in bipolar affective disorder.

21 January 2018

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Cerebral cortex Gs alpha protein levels and forskolin-stimulated cyclic AMP formation are increased in bipolar affective disorder

21 January 2018

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G Protein-coupled cyclic AMP signaling in postmortem brain of subjects with mood disorders: effects of diagnosis, suicide, and treatment at the time of death

21 January 2018

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Hyperfunctional G proteins in mononuclear leukocytes of patients with mania.

21 January 2018

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Abnormal G protein alpha(s) - and alpha(i2)-subunit mRNA expression in bipolar affective disorder

21 January 2018

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Is lithium response related to G(s)alpha levels in transformed lymphoblasts from subjects with bipolar disorder?

21 January 2018

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https://api.crossref.org/works/10.1177%2F070674370204700203

Linkage analysis of fifty-seven microsatellite loci to bipolar disorder.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F070674370204700203

Exclusion of close linkage of bipolar disorder to the Gs-alpha subunit gene in nine Australian pedigrees

21 January 2018

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https://api.crossref.org/works/10.1177%2F070674370204700203

No abnormality in the gene for the G protein stimulatory alpha subunit in patients with bipolar disorder.

21 January 2018

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Stimulatory G-protein alpha-subunit mRNA levels are not increased in autopsied cerebral cortex from patients with bipolar disorder.

21 January 2018

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Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms

21 January 2018

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Activation of protein kinase by physiological concentrations of cyclic AMP.

21 January 2018

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Cyclic nucleotide-dependent protein kinases

21 January 2018

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Lithium modulation of second messenger signal amplification in man: inhibition of phosphatidylinositol-specific phospholipase C and adenylate cyclase activity

21 January 2018

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Differential effects of lithium on platelet protein phosphorylation in bipolar patients and healthy subjects

21 January 2018

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https://api.crossref.org/works/10.1177%2F070674370204700203

Increased cyclic AMP-dependent protein kinase activity in postmortem brain from patients with bipolar affective disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F070674370204700203

Abnormalities of cAMP-dependent endogenous phosphorylation in platelets from patients with bipolar disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F070674370204700203

Platelet alpha-adrenergic binding and biochemical responsiveness in depressed patients and controls

21 January 2018

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Regulation of polyphosphoinositide-specific phospholipase C activity by purified Gq.

21 January 2018

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Isolation and functional characterization of an inositol trisphosphate receptor from brain

21 January 2018

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https://api.crossref.org/works/10.1177%2F070674370204700203

Structure and mechanism of inositol monophosphatase.

21 January 2018

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https://api.crossref.org/works/10.1177%2F070674370204700203

Incorporation of inositol into the phosphoinositides of lymphoblastoid cell lines established from bipolar manic-depressive patients

21 January 2018

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https://api.crossref.org/works/10.1177%2F070674370204700203

Platelet alpha-2 adrenergic receptor-mediated phosphoinositide responses in endogenous depression

21 January 2018

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https://api.crossref.org/works/10.1177%2F070674370204700203

Reduced frontal cortex inositol levels in postmortem brain of suicide victims and patients with bipolar disorder.

21 January 2018

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https://api.crossref.org/works/10.1177%2F070674370204700203

Inositol-1-phosphatase in red blood cells of manic-depressive patients before and during treatment with lithium.

21 January 2018

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https://api.crossref.org/works/10.1177%2F070674370204700203

Platelet membrane phosphatidylinositol-4,5-bisphosphate alterations in bipolar disorder--evidence from a single case study

21 January 2018

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https://api.crossref.org/works/10.1177%2F070674370204700203

Platelet membrane phospholipids in euthymic bipolar disorder patients: are they affected by lithium treatment?

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F070674370204700203

G protein diversity: a distinct class of alpha subunits is present in vertebrates and invertebrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F070674370204700203

Increased G alpha q/11 immunoreactivity in postmortem occipital cortex from patients with bipolar affective disorder.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F070674370204700203

Increased membrane-associated protein kinase C activity and translocation in blood platelets from bipolar affective disorder patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F070674370204700203

Enhanced protein kinase C activity and translocation in bipolar affective disorder brains.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F070674370204700203

Protein kinase C in the postmortem brain of teenage suicide victims.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F070674370204700203

myo-Inositol 1,4,5-trisphosphate stimulates protein phosphorylation in saponin-permeabilized human platelets

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F070674370204700203

Calcium and membrane permeability

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F070674370204700203

The calcium messenger system (1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F070674370204700203

Multiple types of neuronal calcium channels and their selective modulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F070674370204700203

Regulation of inositol 1,4,5-trisphosphate-induced calcium release by inositol 1,4,5-trisphosphate and calcium in human platelets

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F070674370204700203

Intracellular calcium homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F070674370204700203

The multifunctional Ca2+/calmodulin-dependent protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F070674370204700203

Calcium signaling in neurons: molecular mechanisms and cellular consequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F070674370204700203

Calcium/calmodulin-dependent protein kinase types II and IV differentially regulate CREB-dependent gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F070674370204700203

Increased Serum Calcium and Phosphorus with the ‘Switch’ into Manic or Excited Psychotic States

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F070674370204700203

Abnormal intracellular calcium ion concentration in platelets and lymphocytes of bipolar patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F070674370204700203

Increased platelet intracellular calcium concentration in patients with bipolar affective disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F070674370204700203

The calcium second messenger system in bipolar disorders: data supporting new research directions

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F070674370204700203

Elevated basal and thapsigargin-stimulated intracellular calcium of platelets and lymphocytes from bipolar affective disorder patients measured by a fluorometric microassay

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F070674370204700203

Serotonin-induced platelet intracellular calcium mobilization in various psychiatric disorders: is it specific to bipolar disorder?

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F070674370204700203

A G protein directly regulates mammalian cardiac calcium channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F070674370204700203

Associated disturbances in calcium homeostasis and G protein-mediated cAMP signaling in bipolar I disorder.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F070674370204700203

Elevated intracellular calcium levels after 5-HT2 receptor stimulation in platelets of depressed patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F070674370204700203

Platelet and lymphocyte free intracellular calcium in affective disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F070674370204700203

Effects of lithium on platelet ionic intracellular calcium concentration in patients with bipolar (manic-depressive) disorder and healthy controls

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F070674370204700203

High intracellular calcium concentrations in transformed lymphoblasts from subjects with bipolar I disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F070674370204700203

Abnormalities in the cAMP signaling pathway in post-mortem brain tissue from the Stanley Neuropathology Consortium.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F070674370204700203

Calcium function in affective disorders and healthy controls.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F070674370204700203

Calmodulin-activated calcium ATPase in bipolar illness.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F070674370204700203

Deficiency of erythrocyte sodium pump activity in bipolar manic-depressive psychosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F070674370204700203

Cation transport mediated by Na+,K(+)-adenosine triphosphatase in lymphoblastoma cells from patients with bipolar I disorder, their relatives, and unrelated control subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F070674370204700203

The regulation and function of c-fos and other immediate early genes in the nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F070674370204700203

CREB: a stimulus-induced transcription factor activated by a diverse array of extracellular signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F070674370204700203

Identification of a cyclic-AMP-responsive element within the rat somatostatin gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F070674370204700203

Increased temporal cortex CREB concentrations and antidepressant treatment in major depression

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F070674370204700203

Valproate robustly enhances AP-1 mediated gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F070674370204700203

The activation of protein kinase B by H2O2 or heat shock is mediated by phosphoinositide 3-kinase and not by mitogen-activated protein kinase-activated protein kinase-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F070674370204700203

WNT-1 and HGF regulate GSK3 beta activity and beta-catenin signaling in mammary epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F070674370204700203

Differential phosphorylation of human tau isoforms containing three repeats by several protein kinases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F070674370204700203

The multifaceted roles of glycogen synthase kinase 3beta in cellular signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F070674370204700203

The mood-stabilizing agent valproate inhibits the activity of glycogen synthase kinase-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F070674370204700203

CREB DNA binding activity is inhibited by glycogen synthase kinase-3 beta and facilitated by lithium

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F070674370204700203

A molecular mechanism for the effect of lithium on development

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F070674370204700203

Caspase-3 activation induced by inhibition of mitochondrial complex I is facilitated by glycogen synthase kinase-3beta and attenuated by lithium

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F070674370204700203

Regulation and localization of tyrosine216 phosphorylation of glycogen synthase kinase-3beta in cellular and animal models of neuronal degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F070674370204700203

Glycogen synthase kinase-3beta facilitates staurosporine- and heat shock-induced apoptosis. Protection by lithium

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F070674370204700203

Gene expression differences in bipolar disorder revealed by cDNA array analysis of post-mortem frontal cortex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F070674370204700203

The mood-stabilizing agents lithium and valproate robustly increase the levels of the neuroprotective protein bcl-2 in the CNS

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F070674370204700203

Differential display PCR reveals increased expression of 2',3'-cyclic nucleotide 3'-phosphodiesterase by lithium.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F070674370204700203

Identification of a novel lithium regulated gene in rat brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F070674370204700203

Neuronal plasticity and survival in mood disorders.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F070674370204700203

A molecular and cellular theory of depression

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F070674370204700203

Transduction of psychosocial stress into the neurobiology of recurrent affective disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F070674370204700203

A speculative model of affective illness cyclicity based on patterns of drug tolerance observed in amygdala-kindled seizures

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F070674370204700203

21 January 2018

Replenishing the stores

1 reference

https://api.crossref.org/works/10.1177%2F070674370204700203

10.1177/070674370204700203

21 January 2018

Identifiers

DOI

0 references

1 reference