(Q34583429)

English

Design of donecopride, a dual serotonin subtype 4 receptor agonist/acetylcholinesterase inhibitor with potential interest for Alzheimer's disease treatment

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

Design of donecopride, a dual serotonin subtype 4 receptor agonist/acetylcholinesterase inhibitor with potential interest for Alzheimer's disease treatment (English)

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

Alzheimer's disease

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author name string

Cédric Lecoutey

1

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

Damien Hedou

2

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

Thomas Freret

3

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

Patrizia Giannoni

4

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

Florence Gaven

5

1 reference

Europe PubMed Central

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3 August 2017

Marc Since

6

1 reference

Europe PubMed Central

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3 August 2017

Valentine Bouet

7

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

Céline Ballandonne

8

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

Sophie Corvaisier

9

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

Aurélie Malzert Fréon

10

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

Serge Mignani

11

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

Thierry Cresteil

12

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

Michel Boulouard

13

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

Sylvie Claeysen

14

1 reference

Europe PubMed Central

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3 August 2017

Christophe Rochais

15

1 reference

Europe PubMed Central

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3 August 2017

Patrick Dallemagne

16

1 reference

Europe PubMed Central

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3 August 2017

language of work or name

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publication date

25 August 2014

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Europe PubMed Central

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3 August 2017

Proceedings of the National Academy of Sciences of the United States of America

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Europe PubMed Central

PubMed publication ID

3 August 2017

111

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Europe PubMed Central

PubMed publication ID

3 August 2017

36

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

E3825-30

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

Genetic modulation of soluble Aβ rescues cognitive and synaptic impairment in a mouse model of Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246933

7 July 2018

An antidepressant decreases CSF Aβ production in healthy individuals and in transgenic AD mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246933

7 July 2018

Synthesis and structure-activity relationship studies of conformationally flexible tetrahydroisoquinolinyl triazole carboxamide and triazole substituted benzamide analogues as σ2 receptor ligands.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246933

7 July 2018

Multi-target design strategies in the context of Alzheimer's disease: acetylcholinesterase inhibition and NMDA receptor antagonism as the driving forces

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246933

7 July 2018

Early administration of RS 67333, a specific 5-HT4 receptor agonist, prevents amyloidogenesis and behavioral deficits in the 5XFAD mouse model of Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246933

7 July 2018

A review on cholinesterase inhibitors for Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246933

7 July 2018

5-HT4 receptors constitutively promote the non-amyloidogenic pathway of APP cleavage and interact with ADAM10.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246933

7 July 2018

Identification of multiple 5-HT₄ partial agonist clinical candidates for the treatment of Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246933

7 July 2018

A biphasic and brain-region selective down-regulation of cyclic adenosine monophosphate concentrations supports object recognition in the rat

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246933

7 July 2018

Serotonin signaling is associated with lower amyloid-β levels and plaques in transgenic mice and humans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246933

7 July 2018

Alzheimer's disease: strategies for disease modification

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246933

7 July 2018

Effects of the 5-HT(4) receptor agonist RS67333 and paroxetine on hippocampal extracellular 5-HT levels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246933

7 July 2018

Virtual screening discovery of new acetylcholinesterase inhibitors issued from CERMN chemical library

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246933

7 July 2018

Selective serotonin reuptake inhibitors potentiate the rapid antidepressant-like effects of serotonin4 receptor agonists in the rat

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246933

7 July 2018

Design, synthesis, and biological evaluation of new 5-HT4 receptor agonists: application as amyloid cascade modulators and potential therapeutic utility in Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246933

7 July 2018

Multi-target-directed ligands to combat neurodegenerative diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246933

7 July 2018

Recent developments in cholinesterases inhibitors for Alzheimer's disease treatment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246933

7 July 2018

Serotonin(4) (5-HT(4)) receptor agonists are putative antidepressants with a rapid onset of action

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246933

7 July 2018

Anti-dementia drugs and hippocampal-dependent memory in rodents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246933

7 July 2018

5-HT4 receptor and Alzheimer's disease: the amyloid connection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246933

7 July 2018

Activation of 5-HT4 receptors inhibits secretion of beta-amyloid peptides and increases neuronal survival

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246933

7 July 2018

Acquisition, retention, and recall of memory after injection of RS67333, a 5-HT(4) receptor agonist, into the nucleus basalis magnocellularis of the rat.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246933

7 July 2018

A new and rapid colorimetric determination of acetylcholinesterase activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246933

7 July 2018

SL65.0155, a novel 5-hydroxytryptamine(4) receptor partial agonist with potent cognition-enhancing properties

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246933

7 July 2018

Enhancement of place and object recognition memory in young adult and old rats by RS 67333, a partial agonist of 5-HT4 receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246933

7 July 2018

Neurochemical and electrophysiological evidence that 5-HT4 receptors exert a state-dependent facilitatory control in vivo on nigrostriatal, but not mesoaccumbal, dopaminergic function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246933

7 July 2018

Evidence for involvement of central 5-HT(4) receptors in cholinergic function associated with cognitive processes: behavioral, electrophysiological, and neurochemical studies.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246933

7 July 2018

Donepezil hydrochloride (E2020) and other acetylcholinesterase inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246933

7 July 2018

The effects of novel, selective 5-hydroxytryptamine (5-HT)4 receptor ligands in rat spatial navigation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246933

7 July 2018

Ability of 5-HT4 receptor ligands to modulate rat striatal dopamine release in vitro and in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246933

7 July 2018

5-HT4 receptor-mediated modulation of 5-HT release in the rat hippocampus in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246933

7 July 2018

Serotonin 5-HT2a and 5-HT2c receptors stimulate amyloid precursor protein ectodomain secretion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246933

7 July 2018

Pharmacological characterization of two novel and potent 5-HT4 receptor agonists, RS 67333 and RS 67506, in vitro and in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246933

7 July 2018

5-HT4 receptor stimulation facilitates acetylcholine release in rat frontal cortex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246933

7 July 2018

Effects of 5-HT4 receptor stimulation on basal and electrically evoked release of acetylcholine from guinea-pig myenteric plexus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246933

7 July 2018

Effects of a putative antidepressant with a rapid onset of action in defeated mice with different coping strategies.

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1410315111

21 January 2018

Dual effects of 5-HT4 receptor activation on GABA release from guinea pig hippocampal slices

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1410315111

21 January 2018

Increased particulate phosphodiesterase 4 in the prefrontal cortex supports 5-HT4 receptor-induced improvement of object recognition memory in the rat.

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1410315111

21 January 2018

Combined treatment with galanthaminium bromide, a new cholinesterase inhibitor, and RS 67333, a partial agonist of 5-HT4 receptors, enhances place and object recognition in young adult and old rats.

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1410315111

21 January 2018

Acetylcholinesterase accelerates assembly of amyloid-beta-peptides into Alzheimer's fibrils: possible role of the peripheral site of the enzyme.

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1410315111

21 January 2018

Synergistic effect of acetylcholinesterase inhibition (donepezil) and 5-HT(4) receptor activation (RS67333) on object recognition in mice.

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1410315111

21 January 2018

Crosstalk between Rap1 and Rac regulates secretion of sAPPalpha

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1410315111

21 January 2018

High throughput UV method for the estimation of thermodynamic solubility and the determination of the solubility in biorelevant media

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1410315111

21 January 2018

The physicochemical challenges of designing multiple ligands

1 reference

https://pubmed.ncbi.nlm.nih.gov/25157130

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A steric blockade model for inhibition of acetylcholinesterase by peripheral site ligands and substrate

1 reference

https://pubmed.ncbi.nlm.nih.gov/25157130

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PAMPA--critical factors for better predictions of absorption

1 reference

https://pubmed.ncbi.nlm.nih.gov/25157130

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1073/PNAS.1410315111

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

2014PNAS..111E3825L

0 references

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

ResearchGate publication ID

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