(Q34587682)

3 August 2017

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title

Preorganization and protein dynamics in enzyme catalysis (English)

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3 August 2017

P T Ravi Rajagopalan

1

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3 August 2017

Stephen J Benkovic

series ordinal

2

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3 August 2017

language of work or name

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1 January 2002

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3 August 2017

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3 August 2017

volume

2

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3 August 2017

issue

1

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3 August 2017

page(s)

24-36

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3 August 2017

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Chemical basis for enzyme catalysis

21 January 2018

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A perspective on biological catalysis

21 January 2018

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Electrostatic origin of the catalytic power of enzymes and the role of preorganized active sites

21 January 2018

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Phosphonate analogues of carboxypeptidase A substrates are potent transition-state analogue inhibitors

21 January 2018

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Synthesis and evaluation of an inhibitor of carboxypeptidase A with a Ki value in the femtomolar range

21 January 2018

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Transition-state characterization: a new approach combining inhibitor analogs and variation in enzyme structure

21 January 2018

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At the crossroads of chemistry and immunology: catalytic antibodies

21 January 2018

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21 January 2018

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21 January 2018

Computational enzymology

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The importance of reactant positioning in enzyme catalysis: a hybrid quantum mechanics/molecular mechanics study of a haloalkane dehalogenase

21 January 2018

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Active site dynamics of the HhaI methyltransferase: insights from computer simulation

21 January 2018

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The small subunit of carbamoyl phosphate synthetase: snapshots along the reaction pathway

21 January 2018

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Computer simulations of enzyme catalysis: finding out what has been optimized by evolution.

21 January 2018

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Unmasking of hydrogen tunneling in the horse liver alcohol dehydrogenase reaction by site-directed mutagenesis

21 January 2018

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Entropic Contributions to Rate Accelerations in Enzymic and Intramolecular Reactions and the Chelate Effect

21 January 2018

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So do we understand how enzymes work?

21 January 2018

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How important are entropic contributions to enzyme catalysis?

21 January 2018

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Dynamics of the dihydrofolate reductase-folate complex: catalytic sites and regions known to undergo conformational change exhibit diverse dynamical features

21 January 2018

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Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence

21 January 2018

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Crystal structures of Escherichia coli dihydrofolate reductase: the NADP+ holoenzyme and the folate.NADP+ ternary complex. Substrate binding and a model for the transition state

21 January 2018

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Determination by Raman spectroscopy of the pKa of N5 of dihydrofolate bound to dihydrofolate reductase: mechanistic implications

21 January 2018

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Crystal structures of Escherichia coli dihydrofolate reductase complexed with 5-formyltetrahydrofolate (folinic acid) in two space groups: evidence for enolization of pteridine O4

21 January 2018

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Construction and evaluation of the kinetic scheme associated with dihydrofolate reductase from Escherichia coli

21 January 2018

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Stretching exercises--flexibility in dihydrofolate reductase catalysis

21 January 2018

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Insights into enzyme function from studies on mutants of dihydrofolate reductase

21 January 2018

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Nonadditivity of mutational effects at the folate binding site of Escherichia coli dihydrofolate reductase

21 January 2018

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Interloop contacts modulate ligand cycling during catalysis by Escherichia coli dihydrofolate reductase

21 January 2018

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Molecular basis for nonadditive mutational effects in Escherichia coli dihydrofolate reductase

21 January 2018

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Dynamics of a flexible loop in dihydrofolate reductase from Escherichia coli and its implication for catalysis.

21 January 2018

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Enzyme dynamics and hydrogen tunnelling in a thermophilic alcohol dehydrogenase.

21 January 2018

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Converting trypsin to chymotrypsin: the role of surface loops

21 January 2018

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Structural origins of substrate discrimination in trypsin and chymotrypsin

21 January 2018

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Evolutionarily conserved pathways of energetic connectivity in protein families

21 January 2018

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Rates of Uncatalyzed Peptide Bond Hydrolysis in Neutral Solution and the Transition State Affinities of Proteases

21 January 2018

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Energetically most likely substrate and active-site protonation sites and pathways in the catalytic mechanism of dihydrofolate reductase

21 January 2018

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Ground State and Transition State Contributions to the Rates of Intramolecular and Enzymatic Reactions

21 January 2018

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Molecular Dynamics Simulations of Ground and Transition States for the Hydride Transfer from Formate to NAD+in the Active Site of Formate Dehydrogenase

21 January 2018

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Nature of Forces between Large Molecules of Biological Interest*

21 January 2018

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Enzymatic transition states and transition state analog design

21 January 2018

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MECHANISM OF ENZYME CATALYSIS

21 January 2018

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Solvation, reorganization energy, and biological catalysis

21 January 2018

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21 January 2018

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Temperature effects on the catalytic efficiency, rate enhancement, and transition state affinity of cytidine deaminase, and the thermodynamic consequences for catalysis of removing a substrate "anchor"

21 January 2018

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21 January 2018

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Functionally important correlated motions in the single-stranded DNA-binding protein encoded by filamentous phage Pf3

21 January 2018

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Evidence for a functional role of the dynamics of glycine-121 of Escherichia coli dihydrofolate reductase obtained from kinetic analysis of a site-directed mutant

21 January 2018

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Functional role of a mobile loop of Escherichia coli dihydrofolate reductase in transition-state stabilization

21 January 2018

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Strength of an interloop hydrogen bond determines the kinetic pathway in catalysis by Escherichia coli dihydrofolate reductase

21 January 2018

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Deletion of a highly motional residue affects formation of the Michaelis complex for Escherichia coli dihydrofolate reductase

21 January 2018

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Complementary perturbation of the kinetic mechanism and catalytic effectiveness of dihydrofolate reductase by side-chain interchange

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/TCR.10009

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3 August 2017

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