(Q34602588)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17227231%20AND%20SRC:MED&resulttype=core&format=json

24 December 2019

review article

1 reference

title

Protection of endogenous enkephalin catabolism as natural approach to novel analgesic and antidepressant drugs (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17227231%20AND%20SRC:MED&resulttype=core&format=json

24 December 2019

0 references

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17227231%20AND%20SRC:MED&resulttype=core&format=json

24 December 2019

author name string

Bernard P Roques

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17227231%20AND%20SRC:MED&resulttype=core&format=json

24 December 2019

language of work or name

English

0 references

publication date

1 February 2007

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17227231%20AND%20SRC:MED&resulttype=core&format=json

Expert Opinion on Therapeutic Targets

24 December 2019

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17227231%20AND%20SRC:MED&resulttype=core&format=json

24 December 2019

volume

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17227231%20AND%20SRC:MED&resulttype=core&format=json

24 December 2019

issue

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17227231%20AND%20SRC:MED&resulttype=core&format=json

24 December 2019

page(s)

145-159

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17227231%20AND%20SRC:MED&resulttype=core&format=json

(D-Ala2)-Met-enkephalinamide: a potent, long-lasting synthetic pentapeptide analgesic

24 December 2019

cites work

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.145

Stereospecific Binding of the Potent Narcotic Analgesic [ 3 H]Etorphine to Rat-Brain Homogenate

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.145

Identification of two related pentapeptides from the brain with potent opiate agonist activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.145

Pre- and postsynaptic distribution of mu, delta and kappa opioid receptors in the superficial layers of the cervical dorsal horn of the rat spinal cord

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.145

Novel approaches to targeting neuropeptide systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.145

Inhibitory potency of various peptides on enkephalinase activity from mouse striatum

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.145

Autoradiographic comparison of the distribution of the neutral endopeptidase "enkephalinase" and of mu and delta opioid receptors in rat brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.145

First discrete autoradiographic distribution of aminopeptidase N in various structures of rat brain and spinal cord using the selective iodinated inhibitor [125I]RB 129.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.145

Analgesic effects of kelatorphan, a new highly potent inhibitor of multiple enkephalin degrading enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.145

"Mixed inhibitor-prodrug" as a new approach toward systemically active inhibitors of enkephalin-degrading enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.145

Aminophosphinic inhibitors as transition state analogues of enkephalin-degrading enzymes: a class of central analgesics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.145

Long lasting antinociceptive properties of enkephalin degrading enzyme (NEP and APN) inhibitor prodrugs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.145

Pain management by a new series of dual inhibitors of enkephalin degrading enzymes: long lasting antinociceptive properties and potentiation by CCK2 antagonist or methadone

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.145

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.145

Pain responses, anxiety and aggression in mice deficient in pre-proenkephalin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.145

Pain-suppressive effects on various nociceptive stimuli (thermal, chemical, electrical and inflammatory) of the first orally active enkephalin-metabolizing enzyme inhibitor RB 120.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.145

Depressant effect on a C-fibre reflex in the rat, of RB101, a dual inhibitor of enkephalin-degrading enzymes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.145

The antinociceptive effects of SCH-32615, a neutral endopeptidase (enkephalinase) inhibitor, microinjected into the periaqueductal, ventral medulla and amygdala

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.145

Analgesic responses elicited by endogenous enkephalins (protected by mixed peptidase inhibitors) in a variety of morphine-sensitive noxious tests.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.145

In vivo occupation of mouse brain opioid receptors by endogenous enkephalins: blockade of enkephalin degrading enzymes by RB 101 inhibits [3H]diprenorphine binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.145

Evidence that endogenous enkephalins and a delta opioid receptor agonist have a common site of action in spinal antinociception

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.145

Effects of opioids and non-opioids on c-Fos-like immunoreactivity induced in rat lumbar spinal cord neurons by noxious heat stimulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.145

The effects of RB101, a mixed inhibitor of enkephalin-catabolizing enzymes, on carrageenin-induced spinal c-Fos expression are completely blocked by beta-funaltrexamine, a selective mu-opioid receptor antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.145

delta-Opioid receptor subtypes and cross-talk with mu-receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.145

Activity of mu- and delta-opioid agonists in vas deferens from mice deficient in MOR gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.145

Potent antinociceptive effects of kelatorphan (a highly efficient inhibitor of multiple enkephalin-degrading enzymes) systemically administered in normal and arthritic rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.145

Lack of significant changes in mu, delta opioid binding sites and neutral endopeptidase EC 3.4.24.11 in the brain and spinal cord of arthritic rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.145

Endothelin-B receptor activation triggers an endogenous analgesic cascade at sites of peripheral injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.145

Local analgesic effect of endogenous opioid peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.145

Antinociceptive response induced by mixed inhibitors of enkephalin catabolism in peripheral inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.145

A selective CCKB receptor antagonist potentiates, mu-, but not delta-opioid receptor-mediated antinociception in the formalin test

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.145

Enhancement of the effects of a complete inhibitor of enkephalin-catabolizing enzymes, RB 101, by a cholecystokinin-B receptor antagonist in diabetic rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.145

Behavioural evidence that systemic morphine may modulate a phasic pain-related behaviour in a rat model of peripheral mononeuropathy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.145

Antinociceptive effect of systemic kelatorphan, in mononeuropathic rats, involves different opioid receptor types

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.145

Opioids can enhance and inhibit the electrically evoked release of methionine-enkephalin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.145

Facilitation of enkephalins catabolism inhibitor-induced antinociception by drugs classically used in pain management

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.145

The d- and l-isomers of methadone bind to the non-competitive site on the N-methyl-D-aspartate (NMDA) receptor in rat forebrain and spinal cord

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.145

Opioid analgesics as noncompetitive N-methyl-D-aspartate (NMDA) antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.145

Combined opioid-NMDA antagonist therapies. What advantages do they offer for the control of pain syndromes?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.145

Antinociceptive effects of RB101(S), a complete inhibitor of enkephalin‐catabolizing enzymes, are enhanced by (+)‐HA966, a functional NMDA receptor antagonist: a c‐Fos study in the rat spinal cord

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.145

Drug choices for intravenous and spinal analgesia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.145

Evidence for the Neuropeptide Cholecystokinin as an Antagonist of Opiate Analgesia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.145

The role of CCK caerulein, and CCK antagonists in nociception

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.145

Cholecystokinin-A but not cholecystokinin-B receptor stimulation induces endogenous opioid-dependent antinociceptive effects in the hot plate test in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.145

Differential interactions of cholecystokinin and FLFQPQRF-NH2 with mu and delta opioid antinociception in the rat spinal cord

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.145

Cholecystokinin and morphine analgesia: variations on a theme

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.145

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.145

CI 988, an antagonist of the cholecystokinin-B receptor, potentiates endogenous opioid-mediated antinociception at spinal level

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.145

A systematic review of psychological factors as predictors of chronicity/disability in prospective cohorts of low back pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.145

Psychological factors in chronic pain: a worthwhile undertaking for nursing?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.145

Antidepressant-type effects of endogenous enkephalins protected by systemic RB 101 are mediated by opioid delta and dopamine D1 receptor stimulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.145

Behavioral and neurobiological effects of the enkephalinase inhibitor RB101 relative to its antidepressant effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.145

Mice deficient for delta- and mu-opioid receptors exhibit opposing alterations of emotional responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.145

Physiological control of emotion-related behaviors by endogenous enkephalins involves essentially the delta opioid receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.145

Female preproenkephalin-knockout mice display altered emotional responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.145

Differences in physical dependence induced by selective mu or delta opioid agonists and by endogenous enkephalins protected by peptidase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.145

Lack of physical dependence in mice after repeated systemic administration of the mixed inhibitor prodrug of enkephalin-degrading enzymes, RB101

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.145

Repeated systemic administration of the mixed inhibitor of enkephalin-degrading enzymes, RB101, does not induce either antinociceptive tolerance or cross-tolerance with morphine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.145

RB101(S), a dual inhibitor of enkephalinases does not induce antinociceptive tolerance, or cross-tolerance with morphine: a c-Fos study at the spinal level.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.145

Inhibition of enkephalin metabolism and activation of mu- or delta-opioid receptors elicit opposite effects on reward and motility in the ventral mesencephalon

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.145

Analgesic doses of the enkephalin degrading enzyme inhibitor RB 120 do not have discriminative stimulus properties.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.145

Unlike morphine the endogenous enkephalins protected by RB101 are unable to establish a conditioned place preference in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.145

Enkephalinase inhibition facilitates sexual behavior in the male rat but does not produce conditioned place preference.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.145

The CCKB antagonist PD-134,308 facilitates rewarding effects of endogenous enkephalins but does not induce place preference in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.145

Potentiation of opioid-induced conditioned place preference by the selective serotonin reuptake inhibitor fluoxetine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.145

Effect of inhibiting enkephalin catabolism in the VTA on motor activity and extracellular dopamine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.145

Acetorphan, an Enkephalinase Inhibitor, Modulates Dopaminergic Transmission in Rat Olfactory Tubercle, but not in the Nucleus Accumbens and Striatum

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.145

Agonists at mu-opioid receptors spin the wheels to keep the action going

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.145

Receptor endocytosis counteracts the development of opioid tolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.145

Endocytosis of the mu opioid receptor reduces tolerance and a cellular hallmark of opiate withdrawal

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.145

Differential sorting of human delta-opioid receptors after internalization by peptide and alkaloid agonists.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.145

Functional dissociation of mu opioid receptor signaling and endocytosis: implications for the biology of opiate tolerance and addiction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.145

Molecular basis of long-term plasticity underlying addiction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.145

Reduction of morphine abstinence in mice with a mutation in the gene encoding CREB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.145

Different effects of μ and δ opiate agonists on respiration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.145

Effects of the potent analgesic enkephalin-catabolizing enzyme inhibitors RB101 and kelatorphan on respiration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.145

Human Opiorphin, a natural antinociceptive modulator of opioid-dependent pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.145

Pharmacological profile of the selective FAAH inhibitor KDS-4103 (URB597).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.145

NK1 (substance P) receptor antagonists--why are they not analgesic in humans?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.145

Have Cox2 inhibitors lived up to expectations?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.145

Efficacy and tolerability of racecadotril in acute diarrhea in children

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.145

Stereospecific Interaction Between Narcotic Analgesics and a Synaptic Plasma Membrane Fraction of Rat Cerebral Cortex

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.145

Analgesia induced in vivo by central administration of enkephalin in rat

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.145

The enkephalinase inhibitor thiorphan shows antinociceptive activity in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.145

10.1517/14728222.11.2.145

21 January 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17227231%20AND%20SRC:MED&resulttype=core&format=json

24 December 2019

1 reference