(Q34608711)

3 August 2017

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title

Structure-based screening and design in drug discovery (English)

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3 August 2017

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Maria van Dongen

1

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3 August 2017

Johan Weigelt

2

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3 August 2017

Jonas Uppenberg

3

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3 August 2017

Johan Schultz

4

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3 August 2017

Mats Wikström

5

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3 August 2017

publication date

1 April 2002

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3 August 2017

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3 August 2017

volume

7

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3 August 2017

issue

8

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3 August 2017

page(s)

471-478

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Novel inhibitors of DNA gyrase: 3D structure based biased needle screening, hit validation by biophysical methods, and 3D guided optimization. A promising alternative to random screening

3 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902233-X

7 January 2021

Discovering high-affinity ligands for proteins: SAR by NMR

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902233-X

7 January 2021

Mapping of the binding interfaces of the proteins of the bacterial phosphotransferase system, HPr and IIAglc

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902233-X

7 January 2021

Identification of the Contact Surface of a Streptococcal Protein G Domain Complexed with a Human Fc Fragment

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902233-X

7 January 2021

Virtual screening—an overview

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902233-X

7 January 2021

Discovery of small-molecule inhibitors of Bcl-2 through structure-based computer screening

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902233-X

7 January 2021

Applications of NMR in drug discovery

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902233-X

7 January 2021

Library design for NMR-based screening

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902233-X

7 January 2021

The SHAPES strategy: an NMR-based approach for lead generation in drug discovery.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902233-X

7 January 2021

Nuclear magnetic resonance-based approaches for lead generation in drug discovery.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902233-X

7 January 2021

Spin label enhanced NMR screening

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902233-X

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902233-X

7 January 2021

Spin Diffusion Measurements: Spin Echoes in the Presence of a Time-Dependent Field Gradient

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902233-X

7 January 2021

A T1 rho-filtered two-dimensional transferred NOE spectrum for studying antibody interactions with peptide antigens

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902233-X

7 January 2021

Mixture Analysis in Combinatorial Chemistry. Application of Diffusion-Resolved NMR Spectroscopy

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902233-X

7 January 2021

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902233-X

1 reference

7 January 2021

Conformation of a peptide ligand bound to its G-protein coupled receptor

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902233-X

7 January 2021

Characterization of Ligand Binding by Saturation Transfer Difference NMR Spectroscopy

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902233-X

7 January 2021

Identification of compounds with binding affinity to proteins via magnetization transfer from bulk water.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902233-X

7 January 2021

WaterLOGSY as a method for primary NMR screening: practical aspects and range of applicability.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902233-X

7 January 2021

Determination of the binding specificity of an integral membrane protein by saturation transfer difference NMR: RGD peptide ligands binding to integrin alphaIIbbeta3.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902233-X

7 January 2021

Attenuated T2 relaxation by mutual cancellation of dipole-dipole coupling and chemical shift anisotropy indicates an avenue to NMR structures of very large biological macromolecules in solution

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902233-X

7 January 2021

Site-selective screening by NMR spectroscopy with labeled amino acid pairs

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902233-X

7 January 2021

Assignment of the three methionyl carbonyl carbon resonances in Streptomyces subtilisin inhibitor by a carbon-13 and nitrogen-15 double-labeling technique. A new strategy for structural studies of proteins in solution

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902233-X

7 January 2021

Dual amino acid-selective and site-directed stable-isotope labeling of the human c-Ha-Ras protein by cell-free synthesis

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902233-X

7 January 2021

Uncoupling of obesity from insulin resistance through a targeted mutation in aP2, the adipocyte fatty acid binding protein

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902233-X

7 January 2021

Structural studies on human muscle fatty acid binding protein at 1.4 A resolution: binding interactions with three C18 fatty acids

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902233-X

7 January 2021

NMR-based discovery of lead inhibitors that block DNA binding of the human papillomavirus E2 protein

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902233-X

7 January 2021

Phosphopeptide binding to the N‐terminal SH2 domain of the p85α subunit of PI 3′‐kinase: A heteronuclear NMR study

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902233-X

7 January 2021

Solution structure and peptide binding of the SH3 domain from human Fyn

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902233-X

7 January 2021

Protein-ligand interactions: exchange processes and determination of ligand conformation and protein-ligand contacts

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902233-X

7 January 2021

Microsecond time scale dynamics in the RXR DNA-binding domain from a combination of spin-echo and off-resonance rotating frame relaxation measurements

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902233-X

7 January 2021

Direct measurements of the dissociation-rate constant for inhibitor-enzyme complexes via the T1 rho and T2 (CPMG) methods.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902233-X

7 January 2021

Site-directed ligand discovery

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902233-X

7 January 2021

Design of adenosine kinase inhibitors from the NMR-based screening of fragments

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902233-X

7 January 2021

High-throughput nuclear magnetic resonance-based screening

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902233-X

7 January 2021

Improved sensitivity of HSQC spectra of exchanging protons at short interscan delays using a new fast HSQC (FHSQC) detection scheme that avoids water saturation

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902233-X

7 January 2021

10.1016/S1359-6446(02)02233-X

Identifiers

DOI

1 reference

3 August 2017

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