(Q34612373)

3 August 2017

title

An APPL1/Akt signaling complex regulates dendritic spine and synapse formation in hippocampal neurons (English)

1 reference

3 August 2017

1 reference

Devi Majumdar

1

1 reference

3 August 2017

Caroline A Nebhan

2

1 reference

3 August 2017

Lan Hu

3

1 reference

3 August 2017

Bridget Anderson

4

1 reference

3 August 2017

Donna J Webb

5

1 reference

3 August 2017

publication date

12 January 2011

1 reference

Molecular and Cellular Neuroscience

3 August 2017

published in

1 reference

3 August 2017

volume

46

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3 August 2017

issue

3

1 reference

3 August 2017

page(s)

633-644

1 reference

Vasodilator-stimulated phosphoprotein (VASP) induces actin assembly in dendritic spines to promote their development and potentiate synaptic strength

3 August 2017

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1 reference

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7 July 2018

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Structure and function of dendritic spines within the hippocampus.

7 July 2018

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A phosphoinositide switch controls the maturation and signaling properties of APPL endosomes

7 July 2018

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7 July 2018

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Distinct, but compensatory roles of PAK1 and PAK3 in spine morphogenesis

7 July 2018

1 reference

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N-wasp and the arp2/3 complex are critical regulators of actin in the development of dendritic spines and synapses

7 July 2018

1 reference

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The PAR-6 polarity protein regulates dendritic spine morphogenesis through p190 RhoGAP and the Rho GTPase

7 July 2018

1 reference

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A role of the Lowe syndrome protein OCRL in early steps of the endocytic pathway

7 July 2018

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Akt mediates the effect of insulin on epithelial sodium channels by inhibiting Nedd4-2

7 July 2018

1 reference

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Structure of the APPL1 BAR-PH domain and characterization of its interaction with Rab5

7 July 2018

1 reference

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Crystal structures of the BAR-PH and PTB domains of human APPL1

7 July 2018

1 reference

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LTP inhibits LTD in the hippocampus via regulation of GSK3beta

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046229

GIPC is recruited by APPL to peripheral TrkA endosomes and regulates TrkA trafficking and signaling

7 July 2018

1 reference

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APPL1 associates with TrkA and GIPC1 and is required for nerve growth factor-mediated signal transduction

7 July 2018

1 reference

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APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function

7 July 2018

1 reference

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Regulation of dendritic morphogenesis by Ras-PI3K-Akt-mTOR and Ras-MAPK signaling pathways.

7 July 2018

1 reference

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A GIT1/PIX/Rac/PAK signaling module regulates spine morphogenesis and synapse formation through MLC

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046229

The mental retardation protein PAK3 contributes to synapse formation and plasticity in hippocampus

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046229

Structural basis of long-term potentiation in single dendritic spines

7 July 2018

1 reference

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Altered cortical synaptic morphology and impaired memory consolidation in forebrain- specific dominant-negative PAK transgenic mice

7 July 2018

1 reference

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Human follicle-stimulating hormone (FSH) receptor interacts with the adaptor protein APPL1 in HEK 293 cells: potential involvement of the PI3K pathway in FSH signaling

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046229

APPL proteins link Rab5 to nuclear signal transduction via an endosomal compartment

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046229

Akt Phosphorylation of Serine 21 on Pak1 Modulates Nck Binding and Cell Migration

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046229

Mechanisms of synapse assembly and disassembly

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046229

Use of RNA interference-mediated gene silencing and adenoviral overexpression to elucidate the roles of AKT/protein kinase B isoforms in insulin actions

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046229

Synapse formation is regulated by the signaling adaptor GIT1

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046229

APPL suppresses androgen receptor transactivation via potentiating Akt activity

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046229

Rapid induction of dendritic spine morphogenesis by trans-synaptic ephrinB-EphB receptor activation of the Rho-GEF kalirin

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046229

AMPA receptor trafficking and synaptic plasticity

7 July 2018

1 reference

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Mediation of the DCC apoptotic signal by DIP13 alpha

7 July 2018

1 reference

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Dendritic spines: structure, dynamics and regulation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046229

Temporal and spatial distribution of activated Pak1 in fibroblasts

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046229

Missense mutation in PAK3, R67C, causes X-linked nonspecific mental retardation.

7 July 2018

1 reference

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Identification of a chromosome 3p14.3-21.1 gene, APPL, encoding an adaptor molecule that interacts with the oncoprotein-serine/threonine kinase AKT2

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046229

Early induction of Talpha1 alpha-tubulin transcription in neurons of the developing nervous system.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046229

PAK3 mutation in nonsyndromic X-linked mental retardation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046229

Mechanism of activation of protein kinase B by insulin and IGF-1

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046229

Imaging exocytosis and endocytosis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046229

Optical analysis of synaptic vesicle recycling at the frog neuromuscular junction

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046229

The endosomal protein Appl1 mediates Akt substrate specificity and cell survival in vertebrate development

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046229

Pak1 regulates dendritic branching and spine formation

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046229

Role of p21-activated kinase pathway defects in the cognitive deficits of Alzheimer disease.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046229

Bidirectional activity-dependent morphological plasticity in hippocampal neurons

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046229

The kinetics of synaptic vesicle recycling measured at single presynaptic boutons

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046229

Activity-dependent fluorescent staining and destaining of living vertebrate motor nerve terminals

26 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21236345

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Dendritic Spine Pathology: Cause or Consequence of Neurological Disorders?

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21236345

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.MCN.2011.01.003

1 reference

3 August 2017

1 reference

3 August 2017

1 reference