(Q34623795)

3 August 2017

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title

The subcellular destinations of APC proteins (English)

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3 August 2017

Mariann Bienz

1

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3 August 2017

language of work or name

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1 May 2002

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Nature Reviews Molecular Cell Biology

3 August 2017

published in

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3 August 2017

volume

3

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3 August 2017

issue

5

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3 August 2017

page(s)

328-338

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Lessons from hereditary colorectal cancer

3 August 2017

cites work

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Mutations of the APC (adenomatous polyposis coli) gene

31 March 2020

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Familial adenomatous polyposis

31 March 2020

1 reference

Identification and characterization of the familial adenomatous polyposis coli gene

31 March 2020

1 reference

Identification of FAP locus genes from chromosome 5q21

31 March 2020

1 reference

Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene

31 March 2020

1 reference

The type of somatic mutation at APC in familial adenomatous polyposis is determined by the site of the germline mutation: a new facet to Knudson's 'two-hit' hypothesis

31 March 2020

1 reference

APC, signal transduction and genetic instability in colorectal cancer

31 March 2020

1 reference

Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein

31 March 2020

1 reference

Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma

31 March 2020

1 reference

Identification of APC2, a homologue of the adenomatous polyposis coli tumour suppressor

31 March 2020

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A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse

31 March 2020

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Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene

31 March 2020

1 reference

Top-down morphogenesis of colorectal tumors

31 March 2020

1 reference

A Drosophila homolog of the tumor suppressor gene adenomatous polyposis coli down-regulates beta-catenin but its zygotic expression is not essential for the regulation of Armadillo

31 March 2020

1 reference

Identification and characterization of E-APC, a novel Drosophila homologue of the tumour suppressor APC.

31 March 2020

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A Drosophila APC tumour suppressor homologue functions in cellular adhesion

31 March 2020

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Regulation of armadillo by a Drosophila APC inhibits neuronal apoptosis during retinal development

31 March 2020

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A new Drosophila APC homologue associated with adhesive zones of epithelial cells.

31 March 2020

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Drosophila APC2 is a cytoskeletally-associated protein that regulates wingless signaling in the embryonic epidermis

31 March 2020

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Wnt signaling and an APC-related gene specify endoderm in early C. elegans embryos

31 March 2020

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The APC gene product in normal and tumor cells

31 March 2020

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Association of the APC tumor suppressor protein with catenins

31 March 2020

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Association of the APC gene product with beta-catenin

31 March 2020

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From cadherins to catenins: cytoplasmic protein interactions and regulation of cell adhesion

31 March 2020

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The genetic basis of patterned baldness in Drosophila

31 March 2020

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Signal transduction through beta-catenin and specification of cell fate during embryogenesis

31 March 2020

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Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta

31 March 2020

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Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta

31 March 2020

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Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin

31 March 2020

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Apc1638T: a mouse model delineating critical domains of the adenomatous polyposis coli protein involved in tumorigenesis and development

31 March 2020

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Hot spots in beta-catenin for interactions with LEF-1, conductin and APC

31 March 2020

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Axin-dependent phosphorylation of the adenomatous polyposis coli protein mediated by casein kinase 1epsilon

31 March 2020

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Control of beta-catenin stability: reconstitution of the cytoplasmic steps of the wnt pathway in Xenopus egg extracts

31 March 2020

1 reference

31 March 2020

APC: the plot thickens

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The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation

31 March 2020

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Domains of axin involved in protein-protein interactions, Wnt pathway inhibition, and intracellular localization

31 March 2020

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DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability

31 March 2020

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Axin prevents Wnt-3a-induced accumulation of beta-catenin

31 March 2020

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Signaling specificity by Frizzled receptors in Drosophila.

31 March 2020

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Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway

31 March 2020

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arrow encodes an LDL-receptor-related protein essential for Wingless signalling

31 March 2020

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31 March 2020

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Nuclear and cytoplasmic localizations of the adenomatous polyposis coli protein.

31 March 2020

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Cell density and phosphorylation control the subcellular localization of adenomatous polyposis coli protein

31 March 2020

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The adenomatous polyposis coli tumor suppressor protein localizes to plasma membrane sites involved in active cell migration.

31 March 2020

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APC expression in normal human tissues

31 March 2020

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Actin-dependent membrane association of the APC tumour suppressor in polarized mammalian epithelial cells

31 March 2020

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The APC tumour suppressor has a nuclear export function.

31 March 2020

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Nuclear-cytoplasmic shuttling of APC regulates beta-catenin subcellular localization and turnover

31 March 2020

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Adenomatous polyposis coli protein contains two nuclear export signals and shuttles between the nucleus and cytoplasm

31 March 2020

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APC-mediated downregulation of beta-catenin activity involves nuclear sequestration and nuclear export

31 March 2020

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Leptomycin B inhibition of signal-mediated nuclear export by direct binding to CRM1

31 March 2020

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ARM domain-dependent nuclear import of adenomatous polyposis coli protein is stimulated by the B56 alpha subunit of protein phosphatase 2A.

31 March 2020

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Phosphorylation near nuclear localization signal regulates nuclear import of adenomatous polyposis coli protein

31 March 2020

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Nuclear localization signal-independent and importin/karyopherin-independent nuclear import of beta-catenin

31 March 2020

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beta-catenin can be transported into the nucleus in a Ran-unassisted manner

31 March 2020

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Structural basis for the interaction between FxFG nucleoporin repeats and importin-beta in nuclear trafficking

31 March 2020

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CRM1- and Ran-independent nuclear export of beta-catenin.

31 March 2020

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Nuclear export of human beta-catenin can occur independent of CRM1 and the adenomatous polyposis coli tumor suppressor

31 March 2020

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Aneuploid colon cancer cells have a robust spindle checkpoint

31 March 2020

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Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC

31 March 2020

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Negative regulation of Wingless signaling by D-axin, a Drosophila homolog of axin

31 March 2020

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Apical membrane localization of the adenomatous polyposis coli tumor suppressor protein and subcellular distribution of the beta-catenin destruction complex in polarized epithelial cells

31 March 2020

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The tumor suppressor protein APC colocalizes with beta-catenin in the colon epithelial cells

31 March 2020

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Actin-dependent membrane association of a Drosophila epithelial APC protein and its effect on junctional Armadillo.

31 March 2020

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Crystallographic analysis of the recognition of a nuclear localization signal by the nuclear import factor karyopherin alpha

31 March 2020

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Drosophila APC2 and Armadillo participate in tethering mitotic spindles to cortical actin.

31 March 2020

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Ubiquitous expression of a Drosophila adenomatous polyposis coli homolog and its localization in cortical actin caps

31 March 2020

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Adherens junctions inhibit asymmetric division in the Drosophila epithelium

31 March 2020

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Orientation of spindle axis and distribution of plasma membrane proteins during cell division in polarized MDCKII cells

31 March 2020

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Adenomatous polyposis coli (APC) protein moves along microtubules and concentrates at their growing ends in epithelial cells

31 March 2020

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Binding of the adenomatous polyposis coli protein to microtubules increases microtubule stability and is regulated by GSK3 beta phosphorylation

31 March 2020

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Microtubule "plus-end-tracking proteins": The end is just the beginning

31 March 2020

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Critical role for the EB1 and APC interaction in the regulation of microtubule polymerization

31 March 2020

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NH2-terminal deletion of beta-catenin results in stable colocalization of mutant beta-catenin with adenomatous polyposis coli protein and altered MDCK cell adhesion

31 March 2020

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Targeting, capture, and stabilization of microtubules at early focal adhesions

31 March 2020

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Enforced polarisation and locomotion of fibroblasts lacking microtubules

31 March 2020

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Asef, a link between the tumor suppressor APC and G-protein signaling

31 March 2020

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The adenomatous polyposis coli-binding protein EB1 is associated with cytoplasmic and spindle microtubules

31 March 2020

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EB1, a protein which interacts with the APC tumour suppressor, is associated with the microtubule cytoskeleton throughout the cell cycle

31 March 2020

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The dynamic behavior of the APC-binding protein EB1 on the distal ends of microtubules

31 March 2020

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BIM1 encodes a microtubule-binding protein in yeast

31 March 2020

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Mal3, the fission yeast homologue of the human APC-interacting protein EB-1 is required for microtubule integrity and the maintenance of cell form

31 March 2020

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Molecular linkage underlying microtubule orientation toward cortical sites in yeast

31 March 2020

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Positioning of the mitotic spindle by a cortical-microtubule capture mechanism

31 March 2020

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Bim1p/Yeb1p mediates the Kar9p-dependent cortical attachment of cytoplasmic microtubules

31 March 2020

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Kar9p is a novel cortical protein required for cytoplasmic microtubule orientation in yeast

31 March 2020

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Spindles cotton on to junctions, APC and EB1.

31 March 2020

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A role for the Adenomatous Polyposis Coli protein in chromosome segregation

31 March 2020

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Mutations in the APC tumour suppressor gene cause chromosomal instability

31 March 2020

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Genetic instability in colorectal cancers

31 March 2020

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Kinetochore localization of murine Bub1 is required for normal mitotic timing and checkpoint response to spindle damage

31 March 2020

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APC mutations in sporadic colorectal tumors: A mutational "hotspot" and interdependence of the "two hits"

31 March 2020

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Chromosome number and structure both are markedly stable in RER colorectal cancers and are not destabilized by mutation of p53

31 March 2020

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Spectral karyotyping suggests additional subsets of colorectal cancers characterized by pattern of chromosome rearrangement.

31 March 2020

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Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly

31 March 2020

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Casein kinase I phosphorylates the Armadillo protein and induces its degradation in Drosophila

31 March 2020

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Casein kinase I transduces Wnt signals

31 March 2020

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Casein kinase iepsilon in the wnt pathway: regulation of beta-catenin function

31 March 2020

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Regulation and function of the interaction between the APC tumour suppressor protein and EB1

31 March 2020

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Structural basis of the Axin-adenomatous polyposis coli interaction

31 March 2020

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Molecular mechanisms of beta-catenin recognition by adenomatous polyposis coli revealed by the structure of an APC-beta-catenin complex

31 March 2020

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31 March 2020

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Apoptosis and APC in colorectal tumorigenesis

31 March 2020

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Linking colorectal cancer to Wnt signaling

31 March 2020

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Pathways of chromosome alteration in human epithelial cancers.

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRM806

1 reference

Dimensions Publication ID

3 August 2017

1021935829

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