(Q34623823)

3 August 2017

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title

The hypocretins: setting the arousal threshold (English)

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hypocretin receptor binding

3 August 2017

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Gene Ontology release 2020-05-02

J Gregor Sutcliffe

1

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3 August 2017

Luis de Lecea

series ordinal

2

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3 August 2017

language of work or name

English

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publication date

1 May 2002

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Nature Reviews Neuroscience

3 August 2017

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3 August 2017

3

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3 August 2017

339-349

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3 August 2017

5

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https://scigraph.springernature.com/pub.10.1038/nrn808

3 August 2017

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cites work

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21 January 2018

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21 January 2018

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Solution structure of a new hypothalamic neuropeptide, human hypocretin-2/orexin-B

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The lateral hypothalamic area revisited: neuroanatomy, body weight regulation, neuroendocrinology and metabolism

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21 January 2018

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Hypocretin/orexin- and melanin-concentrating hormone-expressing cells form distinct populations in the rodent lateral hypothalamus: relationship to the neuropeptide Y and agouti gene-related protein systems.

21 January 2018

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Chemically defined projections linking the mediobasal hypothalamus and the lateral hypothalamic area.

21 January 2018

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Leptin receptor- and STAT3-immunoreactivities in hypocretin/orexin neurones of the lateral hypothalamus.

21 January 2018

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The suprachiasmatic nucleus projects to posterior hypothalamic arousal systems.

21 January 2018

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Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems

21 January 2018

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Orexin A activates locus coeruleus cell firing and increases arousal in the rat.

21 January 2018

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Orexin receptors couple to Ca2+ channels different from store-operated Ca2+ channels

21 January 2018

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Characterization of recombinant human orexin receptor pharmacology in a Chinese hamster ovary cell-line using FLIPR

21 January 2018

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Orexin-a activates phospholipase C- and protein kinase C-mediated Ca2+ signaling in dopamine neurons of the ventral tegmental area

21 January 2018

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Expression of orexin-A and functional orexin type 2 receptors in the human adult adrenals: implications for adrenal function and energy homeostasis

21 January 2018

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Expression and coupling characteristics of the CRH and orexin type 2 receptors in human fetal adrenals

21 January 2018

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Interaction of the hypocretins with neurotransmitters in the nucleus accumbens

21 January 2018

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Widespread distribution of orexin in rat brain and its regulation upon fasting.

21 January 2018

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Food intake elicited by central administration of orexins/hypocretins: identification of hypothalamic sites of action.

21 January 2018

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Effect of intracerebroventricular orexin-B on food intake in sheep

21 January 2018

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Down regulation of the prepro-orexin gene expression in genetically obese mice

21 January 2018

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Hypothalamic hypocretin/orexin and neuropeptide Y: divergent interaction with energy depletion and leptin.

21 January 2018

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Leptin regulation of prepro-orexin and orexin receptor mRNA levels in the hypothalamus.

21 January 2018

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Neuropeptide Y in central control of feeding and interactions with orexin and leptin.

21 January 2018

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Insulin-induced hypoglycemia increases preprohypocretin (orexin) mRNA in the rat lateral hypothalamic area.

21 January 2018

1 reference

Neurons containing orexin in the lateral hypothalamic area of the adult rat brain are activated by insulin-induced acute hypoglycemia.

21 January 2018

1 reference

Hypoglycemia activates orexin neurons and selectively increases hypothalamic orexin-B levels: responses inhibited by feeding and possibly mediated by the nucleus of the solitary tract

21 January 2018

1 reference

Lowering glucose concentrations increases cytosolic Ca2+ in orexin neurons of the rat lateral hypothalamus

21 January 2018

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Effect of lateral cerebroventricular injection of the appetite-stimulating neuropeptide, orexin and neuropeptide Y, on the various behavioral activities of rats

21 January 2018

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The effect of the orexins on food intake: comparison with neuropeptide Y, melanin-concentrating hormone and galanin.

21 January 2018

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Feeding response to central orexins.

21 January 2018

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Distribution and quantification of immunoreactive orexin A in rat tissues.

21 January 2018

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Characterization of melanin concentrating hormone and preproorexin expression in the murine hypothalamus

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Fluctuation of extracellular hypocretin-1 (orexin A) levels in the rat in relation to the light-dark cycle and sleep-wake activities.

21 January 2018

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Changes in CSF hypocretin-1 (orexin A) levels in rats across 24 hours and in response to food deprivation.

21 January 2018

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Chronic intracerebroventricular administration of orexin-A to rats increases food intake in daytime, but has no effect on body weight

21 January 2018

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Reconceptualizing support systems for persons with challenging behaviors

21 January 2018

1 reference

Evidence that orexin-containing neurones provide direct input to gonadotropin-releasing hormone neurones in the ovine hypothalamus

21 January 2018

1 reference

Activation of ventrolateral preoptic neurons during sleep

21 January 2018

1 reference

Orexin synthesis and response in the gut.

21 January 2018

1 reference

Cardiovascular regulatory actions of the hypocretins in brain.

21 January 2018

1 reference

Orexins/hypocretins regulate drinking behaviour.

21 January 2018

1 reference

Stimulation of gastric acid secretion by centrally administered orexin-A in conscious rats.

21 January 2018

1 reference

The novel brain neuropeptide, orexin-A, modulates the sleep-wake cycle of rats

21 January 2018

1 reference

Wake-promoting and sleep-suppressing actions of hypocretin (orexin): basal forebrain sites of action

21 January 2018

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Orexin A interactions in the hypothalamo-pituitary gonadal axis

21 January 2018

1 reference

Orexins stimulate corticosterone secretion of rat adrenocortical cells, through the activation of the adenylate cyclase-dependent signaling cascade

21 January 2018

1 reference

The central effects of orexin-A in the hypothalamic-pituitary-adrenal axis in vivo and in vitro in male rats

21 January 2018

1 reference

Effects of centrally administered orexin-B and orexin-A: a role for orexin-1 receptors in orexin-B-induced hyperactivity

21 January 2018

1 reference

Hypocretin (orexin) in the rat pineal gland: a central transmitter with effects on noradrenaline-induced release of melatonin

21 January 2018

1 reference

Hypocretin-2 (orexin-B) modulation of superficial dorsal horn activity in rat

21 January 2018

1 reference

Orexin-A, an hypothalamic peptide with analgesic properties

21 January 2018

1 reference

The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene

21 January 2018

1 reference

Identification and functional analysis of mutations in the hypocretin (orexin) genes of narcoleptic canines

21 January 2018

1 reference

Thalamocortical oscillations in the sleeping and aroused brain

21 January 2018

1 reference

Sleep and arousal: thalamocortical mechanisms

21 January 2018

1 reference

The sleep switch: hypothalamic control of sleep and wakefulness

21 January 2018

1 reference

Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation

21 January 2018

1 reference

To eat or to sleep? Orexin in the regulation of feeding and wakefulness

21 January 2018

1 reference

Complex HLA-DR and -DQ interactions confer risk of narcolepsy-cataplexy in three ethnic groups

21 January 2018

1 reference

Hypocretin (orexin) deficiency in human narcolepsy.

21 January 2018

1 reference

CSF hypocretin/orexin levels in narcolepsy and other neurological conditions.

21 January 2018

1 reference

A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains

21 January 2018

1 reference

Reduced number of hypocretin neurons in human narcolepsy

21 January 2018

1 reference

Narcolepsy and the HLA region

21 January 2018

1 reference

Sleep-waking discharge patterns of neurons recorded in the rat perifornical lateral hypothalamic area.

21 January 2018

1 reference

Hypocretin receptor protein and mRNA expression in the dorsolateral pons of rats.

21 January 2018

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Sleep cycle oscillation: reciprocal discharge by two brainstem neuronal groups.

21 January 2018

1 reference

Hypocretin/orexin depolarizes and decreases potassium conductance in locus coeruleus neurons.

21 January 2018

1 reference

Orexin A excites serotonergic neurons in the dorsal raphe nucleus of the rat.

21 January 2018

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Orexins (hypocretins) directly excite tuberomammillary neurons

21 January 2018

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Orexins activate histaminergic neurons via the orexin 2 receptor

21 January 2018

1 reference

Arousal effect of orexin A depends on activation of the histaminergic system

21 January 2018

1 reference

Hypocretin/orexin, sleep and narcolepsy

21 January 2018

1 reference

A cortical neuropeptide with neuronal depressant and sleep-modulating properties

21 January 2018

1 reference

Effects on sleep and wakefulness of the injection of hypocretin-1 (orexin-A) into the laterodorsal tegmental nucleus of the cat.

21 January 2018

1 reference

The hypocretin/orexin ligand-receptor system: implications for sleep and sleep disorders.

21 January 2018

1 reference

Orexins/hypocretins excite basal forebrain cholinergic neurones

21 January 2018

1 reference

Peptides crossing the blood-brain barrier: some unusual observations

21 January 2018

1 reference

Low cerebrospinal fluid hypocretin (Orexin) and altered energy homeostasis in human narcolepsy.

21 January 2018

1 reference

Increased body-mass index in patients with narcolepsy.

21 January 2018

1 reference

Genetic ablation of orexin neurons in mice results in narcolepsy, hypophagia, and obesity.

21 January 2018

1 reference

Hypocretin is an early member of the incretin gene family.

21 January 2018

1 reference

Hypothalamic thermoregulatory pathways in the rat

31 March 2020

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Neurons containing hypocretin (orexin) project to multiple neuronal systems

31 March 2020

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Orexin (hypocretin) neurons contain dynorphin.

31 March 2020

1 reference

Presynaptic and postsynaptic actions and modulation of neuroendocrine neurons by a new hypothalamic peptide, hypocretin/orexin.

31 March 2020

1 reference

Orexin depolarizes rat hypothalamic paraventricular nucleus neurons.

31 March 2020

1 reference

Evidence that NPY Y1 receptors are involved in stimulation of feeding by orexins (hypocretins) in sated rats

31 March 2020

1 reference

Orexin-induced food intake involves neuropeptide Y pathway

31 March 2020

1 reference

Inhibition of food intake by central injection of anti-orexin antibody in fasted rats

31 March 2020

1 reference

Alteration of the expression of the hypocretin (orexin) gene by 2-deoxyglucose in the rat lateral hypothalamic area

31 March 2020

1 reference

Independent feeding and metabolic actions of orexins in mice

31 March 2020

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The effect of food deprivation and experimental diabetes on orexin and NPY mRNA levels

31 March 2020

1 reference

Functional organization of central pathways regulating the cardiovascular system

31 March 2020

1 reference

Sympathetic and cardiovascular actions of orexins in conscious rats

31 March 2020

1 reference

Pressor effects of orexins injected intracisternally and to rostral ventrolateral medulla of anesthetized rats

31 March 2020

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Energy expenditure by intracerebroventricular administration of orexin to anesthetized rats

31 March 2020

1 reference

Orexin-A regulates body temperature in coordination with arousal status.

31 March 2020

1 reference

Hypocretin-1 modulates rapid eye movement sleep through activation of locus coeruleus neurons.

31 March 2020

1 reference

Orexins, a novel family of hypothalamic neuropeptides, modulate pituitary luteinizing hormone secretion in an ovarian steroid-dependent manner

31 March 2020

1 reference

Acute orexin effects on insulin secretion in the rat: in vivo and in vitro studies

31 March 2020

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Possible involvement of orexin in the stress reaction in rats

31 March 2020

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Hypocretin/orexin suppresses corticotroph responsiveness in vitro

31 March 2020

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Hypocretin-2-saporin lesions of the lateral hypothalamus produce narcoleptic-like sleep behavior in the rat.

31 March 2020

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Fos expression in orexin neurons varies with behavioral state.

31 March 2020

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Activity of norepinephrine-containing locus coeruleus neurons in behaving rats anticipates fluctuations in the sleep-waking cycle.

31 March 2020

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Loss of behavioral thermoregulation after lateral hypothalamic lesions in rats

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRN808

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Dimensions Publication ID

3 August 2017

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1 reference