(Q34624639)

3 August 2017

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title

Searching for type 2 diabetes genes: prospects in pharmacotherapy (English)

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3 August 2017

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Sesti G

1

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3 August 2017

publication date

1 January 2002

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The Pharmacogenomics Journal

3 August 2017

published in

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3 August 2017

volume

2

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3 August 2017

issue

1

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3 August 2017

page(s)

25-29

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Searching for type 2 diabetes genes in the post-genome era.

3 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500078

Mutations in the hepatocyte nuclear factor-4alpha gene in maturity-onset diabetes of the young (MODY1)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500078

Nonsense mutation in the glucokinase gene causes early-onset non-insulin-dependent diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500078

Mutations in the hepatocyte nuclear factor-1alpha gene in maturity-onset diabetes of the young (MODY3)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500078

Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500078

Mutation in hepatocyte nuclear factor-1 beta gene (TCF2) associated with MODY.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500078

Mutations in NEUROD1 are associated with the development of type 2 diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500078

A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500078

PPAR gamma mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500078

Inhibition of RXR and PPARgamma ameliorates diet-induced obesity and type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500078

A common amino acid polymorphism in insulin receptor substrate-1 causes impaired insulin signaling. Evidence from transfection studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500078

The Gly972-->Arg amino acid polymorphism in IRS-1 impairs insulin secretion in pancreatic beta cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500078

The Gly972Arg polymorphism in the insulin receptor substrate-1 gene contributes to the variation in insulin secretion in normal glucose-tolerant humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500078

Sequence variants in the sulfonylurea receptor (SUR) gene are associated with NIDDM in Caucasians

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500078

Decreased tolbutamide-stimulated insulin secretion in healthy subjects with sequence variants in the high-affinity sulfonylurea receptor gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500078

Searching for genetic determinants in the new millennium

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500078

Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500078

A common polymorphism in the promoter of UCP2 is associated with decreased risk of obesity in middle-aged humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500078

Physiological levels of mammalian uncoupling protein 2 do not uncouple yeast mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500078

Altered insulin secretory responses to glucose in diabetic and nondiabetic subjects with mutations in the diabetes susceptibility gene MODY3 on chromosome 12.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500078

Hyperexcitability to sulphonylurea in MODY3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500078

A genome-wide search for human non-insulin-dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500078

Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500078

A calpain-10 gene polymorphism is associated with reduced muscle mRNA levels and insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500078

Role of calpain in adipocyte differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500078

The insulin-induced down-regulation of IRS-1 in 3T3-L1 adipocytes is mediated by a calcium-dependent thiol protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500078

Calpains play a role in insulin secretion and action

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500078

An autosomal genomic scan for loci linked to type II diabetes mellitus and body-mass index in Pima Indians

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500078

A genomewide scan for loci predisposing to type 2 diabetes in a U.K. population (the Diabetes UK Warren 2 Repository): analysis of 573 pedigrees provides independent replication of a susceptibility locus on chromosome 1q

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500078

Linkage of type 2 diabetes mellitus and of age at onset to a genetic location on chromosome 10q in Mexican Americans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500078

Type 2 diabetes: evidence for linkage on chromosome 20 in 716 Finnish affected sib pairs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500078

Genomewide search for type 2 diabetes-susceptibility genes in French whites: evidence for a novel susceptibility locus for early-onset diabetes on chromosome 3q27-qter and independent replication of a type 2-diabetes locus on chromosome 1q21-q24.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500078

Decreased expression of apM1 in omental and subcutaneous adipose tissue of humans with type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500078

Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500078

Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500078

The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500078

The adipocyte-secreted protein Acrp30 enhances hepatic insulin action

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500078

Loci on chromosomes 2 (NIDDM1) and 15 interact to increase susceptibility to diabetes in Mexican Americans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500078

The Genetic Basis of Plasma Variation in Adiponectin, a Global Endophenotype for Obesity and the Metabolic Syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500078

The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500078

7 January 2021

The mechanisms by which both heterozygous peroxisome proliferator-activated receptor gamma (PPARgamma) deficiency and PPARgamma agonist improve insulin resistance

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500078

7 January 2021

The common Arg972 polymorphism in insulin receptor substrate-1 causes apoptosis of human pancreatic islets

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500078

7 January 2021

Sensitivity to sulphonylureas in patients with hepatocyte nuclear factor-1alpha gene mutations: evidence for pharmacogenetics in diabetes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500078

7 January 2021

Mapping of a gene for type 2 diabetes associated with an insulin secretion defect by a genome scan in Finnish families

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500078

7 January 2021

Identifiers

DOI

10.1038/SJ.TPJ.6500078

1 reference

Dimensions Publication ID

3 August 2017

1033318206

0 references

1 reference