(Q34635461)

3 August 2017

1 reference

title

Leptin and the treatment of obesity: its current status (English)

1 reference

3 August 2017

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Daniel W Lee

1

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3 August 2017

Matthew C Leinung

series ordinal

2

1 reference

3 August 2017

Marina Rozhavskaya-Arena

series ordinal

3

1 reference

3 August 2017

Patricia Grasso

series ordinal

4

1 reference

3 August 2017

language of work or name

English

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publication date

1 April 2002

1 reference

European Journal of Pharmacology

3 August 2017

1 reference

3 August 2017

440

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3 August 2017

2-3

1 reference

3 August 2017

129-139

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

3 August 2017

1 reference

Leptin accelerates the onset of puberty in normal female mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

Rodent mutant models of obesity and their correlations to human obesity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

The stomach is a source of leptin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

Leptin enters the brain by a saturable system independent of insulin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

Leptin is a metabolic signal to the reproductive system.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

The response of the reproductive system in the female mutant mouse, obese (genotype obob) to gonadotrophin-releasing hormones

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

A role for leptin and its cognate receptor in hematopoiesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

Divergent signaling capacities of the long and short isoforms of the leptin receptor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

The role of SOCS-3 in leptin signaling and leptin resistance

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

Plasma leptin levels in healthy children and adolescents: dependence on body mass index, body fat mass, gender, pubertal stage, and testosterone

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

Effect of fasting on serum leptin in normal human subjects.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

Plasma leptin levels are increased in survivors of acute sepsis: associated loss of diurnal rhythm, in cortisol and leptin secretion.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

Leptin, the product of Ob gene, promotes angiogenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

Decreased cerebrospinal-fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistance

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

Regulation of in vivo growth hormone secretion by leptin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

Presence of leptin in colostrum and/or breast milk from lactating mothers: a potential role in the regulation of neonatal food intake

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

Serum leptin concentration in women: effect of age, obesity, and estrogen administration

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

Cell-mediated immunity in genetically obese C57BL/6J ob/ob) mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

Early onset of reproductive function in normal female mice treated with leptin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

Novel B219/OB receptor isoforms: possible role of leptin in hematopoiesis and reproduction

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

Plasma leptin levels do not change in patients with Cushing's disease shortly after correction of hypercortisolism.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

Leptin induces angiopoietin-2 expression in adipose tissues

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

Valvular heart disease associated with fenfluramine-phentermine

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

Leptin and the regulation of body weight

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

Serum immunoreactive-leptin concentrations in normal-weight and obese humans

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

Mutation screening and identification of a sequence variation in the human ob gene coding region

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

A review of the microcirculation of adipose tissue: anatomic, metabolic, and angiogenic perspectives

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

Weight control and risk factor reduction in obese subjects treated for 2 years with orlistat: a randomized controlled trial

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

Serum leptin concentration, body composition, and gonadal hormones during puberty

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

Thyroid hormones modulate serum leptin levels: observations in thyrotoxic and hypothyroid women

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

Effects of recombinant leptin therapy in a child with congenital leptin deficiency.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

Immune response in the mutant diabetic C57BL/Ks-dt+ mouse. Discrepancies between in vitro and in vivo immunological assays

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

Leptin enhances wound re-epithelialization and constitutes a direct function of leptin in skin repair

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

Leptin and the regulation of body weight in mammals

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

Leptin can induce proliferation, differentiation, and functional activation of hemopoietic cells.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

Defective STAT signaling by the leptin receptor in diabetic mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

Leptin(116-130) stimulates prolactin and luteinizing hormone secretion in fasted adult male rats.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

Effects of weight loss on regional fat distribution and insulin sensitivity in obesity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

Epitope mapping of secreted mouse leptin utilizing peripherally administered synthetic peptides

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

Inhibitory effects of leptin-related synthetic peptide 116-130 on food intake and body weight gain in female C57BL/6J ob/ob mice may not be mediated by peptide activation of the long isoform of the leptin receptor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

[D-LEU-4]-OB3, a synthetic leptin agonist, improves hyperglycemic control in C57BL/6J ob/ob mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

Endotoxin and cytokines induce expression of leptin, the ob gene product, in hamsters

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

A polymorphism in the 5' untranslated region of the human ob gene is associated with low leptin levels

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

Weight-reducing effects of the plasma protein encoded by the obese gene

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

Increased obese mRNA expression in omental fat cells from massively obese humans

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

Leptin--much more than a satiety signal

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

Recombinant leptin for weight loss in obese and lean adults: a randomized, controlled, dose-escalation trial

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

Orlistat, a lipase inhibitor, for weight maintenance after conventional dieting: a 1-y study

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

Physiological roles of the leptin endocrine system: differences between mice and humans

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

Role of orlistat in the treatment of obese patients with type 2 diabetes. A 1-year randomized double-blind study

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

Modulation of circulating leptin levels by its soluble receptor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

Weekly subcutaneous pegylated recombinant native human leptin (PEG-OB) administration in obese men.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

Obese, a new mutation in the house mouse

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

Structural organization and chromosomal assignment of the human obese gene

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

A role for leptin in sexual maturation and puberty?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

Obesity as a medical problem

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

Acute and chronic effects of insulin on leptin production in humans: Studies in vivo and in vitro

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

Identification of a fetal hematopoietic precursor with B cell, T cell, and macrophage potential

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

Abnormal splicing of the leptin receptor in diabetic mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

Absence of soluble leptin receptor in plasma from dbPas/dbPas and other db/db mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

Overexpression of the obese (ob) gene in adipose tissue of human obese subjects

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

Threading analysis suggests that the obese gene product may be a helical cytokine

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

Effects of recombinant murine leptin[1-147] and leptin fragment 116-130 on steroid secretion and proliferative activity of the regenerating rat adrenal cortex

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

Leptin prolonged administration inhibits the growth and glucocorticoid secretion of rat adrenal cortex

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

Effect of birth weight and maternal smoking on cord blood leptin concentrations of full-term and preterm newborns

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

Circulating insulin concentrations, smoking, and alcohol intake are important independent predictors of leptin in young healthy men.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

Nonadipose tissue production of leptin: leptin as a novel placenta-derived hormone in humans

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

Leptin Is Inversely Related to Age at Menarche in Human Females

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

Congenital leptin deficiency is associated with severe early-onset obesity in humans

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

A common pentanucleotide polymorphism of the 3'-untranslated part of the leptin receptor gene generates a putative stem-loop motif in the mRNA and is associated with serum insulin levels in obese individuals

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

Effects of the obese gene product on body weight regulation in ob/ob mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

Leptin inhibits in vitro hypothalamic somatostatin secretion and somatostatin mRNA levels

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

Changes in plasma leptin during the menstrual cycle

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

Systemically and topically administered leptin both accelerate wound healing in diabetic ob/ob mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

7 January 2021

The new obesity genes.

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

Design of a synthetic leptin agonist: effects on energy balance, glucose homeostasis, and thermoregulation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

Sibutramine: a novel new agent for obesity treatment

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

A 35 amino acid fragment of leptin inhibits feeding in the rat.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

Biological action of leptin as an angiogenic factor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

Randomised placebo-controlled trial of orlistat for weight loss and prevention of weight regain in obese patients. European Multicentre Orlistat Study Group

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

Regulation of expression of ob mRNA and protein by glucocorticoids and cAMP.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

Obesity and the regulation of energy balance

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

A leptin missense mutation associated with hypogonadism and morbid obesity.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

Reproductive Hormonal Function in the Genetically Obese (ob/ob) Mouse

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

Identification and expression cloning of a leptin receptor, OB-R

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

In vitro pituitary and testicular effects of the leptin-related synthetic peptide leptin(116-130) amide involve actions both similar to and distinct from those of the native leptin molecule in the adult rat.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

Acute cold-induced suppression of ob (obese) gene expression in white adipose tissue of mice: mediation by the sympathetic system

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

Functional properties of leptin receptor isoforms: internalization and degradation of leptin and ligand-induced receptor downregulation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

A nutrient-sensing pathway regulates leptin gene expression in muscle and fat.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

A novel leptin receptor isoform in rat.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

Recombinant ob protein reduces feeding and body weight in the ob/ob mouse

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

Prospective study of intentional weight loss and mortality in never-smoking overweight US white women aged 40-64 years

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

Relationship of the white blood cell count to body fat: role of leptin.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

Positional cloning of the mouse obese gene and its human homologue

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

Crystal structure of the obese protein leptin-E100

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901424-3

10.1016/S0014-2999(02)01424-3

7 January 2021

Identifiers

DOI

1 reference

3 August 2017

1 reference