(Q34636088)

English

PBPK modeling/Monte Carlo simulation of methylene chloride kinetic changes in mice in relation to age and acute, subchronic, and chronic inhalation exposure.

scientific article

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scholarly article

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8875160%20AND%20SRC:MED&resulttype=core&format=json

20 October 2019

PBPK modeling/Monte Carlo simulation of methylene chloride kinetic changes in mice in relation to age and acute, subchronic, and chronic inhalation exposure (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8875160%20AND%20SRC:MED&resulttype=core&format=json

20 October 2019

Melvin E. Andersen

10

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20 October 2019

author name string

R S Thomas

1

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20 October 2019

R S Yang

2

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20 October 2019

D G Morgan

3

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20 October 2019

M P Moorman

4

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20 October 2019

H R Kermani

5

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20 October 2019

R A Sloane

6

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20 October 2019

R W O'Connor

7

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20 October 2019

B Adkins

8

1 reference

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20 October 2019

M L Gargas

9

1 reference

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20 October 2019

publication date

1 August 1996

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20 October 2019

number of pages

8

1 reference

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inferred from page(s)

Environmental Health Perspectives

1 reference

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20 October 2019

104

1 reference

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20 October 2019

8

1 reference

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20 October 2019

858-865

1 reference

Europe PubMed Central

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20 October 2019

Incorporating Monte Carlo simulation into physiologically based pharmacokinetic models using advanced continuous simulation language (ACSL): a computational method.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1469447

7 July 2018

Age-specific carcinogenesis: environmental exposure and susceptibility

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1469447

7 July 2018

Effect of varying exposure regimens on methylene chloride-induced lung and liver tumors in female B6C3F1 mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1469447

7 July 2018

Characterization of p53 mutations in methylene chloride-induced lung tumors from B6C3F1 mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1469447

7 July 2018

Ras proto-oncogene activation in liver and lung tumors from B6C3F1 mice exposed chronically to methylene chloride

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1469447

7 July 2018

Mutational specificities of environmental carcinogens in the lacI gene of Escherichia coli. VI: Analysis of methylene chloride-induced mutational distribution in Uvr+ and UvrB- strains.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1469447

7 July 2018

Methylene chloride-induced tumorigenesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1469447

7 July 2018

Noninvasive measurement of ascending aortic blood velocity in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1469447

7 July 2018

A physiologically based toxicokinetic description of the metabolism of inhaled gases and vapors: Analysis at steady state*1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1469447

7 July 2018

Identification of three classes of cytosolic glutathione transferase common to several mammalian species: correlation between structural data and enzymatic properties

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1469447

7 July 2018

A physiologically based simulation approach for determining metabolic constants from gas uptake data

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1469447

7 July 2018

Physiologically based pharmacokinetic modeling with methylchloroform: implications for interspecies, high dose/low dose, and dose route extrapolations.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1469447

7 July 2018

Influences of dietary restriction and age on liver enzyme activities and lipid peroxidation in mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1469447

7 July 2018

Partition coefficients of low-molecular-weight volatile chemicals in various liquids and tissues

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1469447

7 July 2018

In vitro metabolism of methylene chloride in human and animal tissues: use in physiologically based pharmacokinetic models

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1469447

7 July 2018

Determining kinetic constants of chlorinated ethane metabolism in the rat from rates of exhalation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1469447

7 July 2018

Variability of safe dose estimates when using complicated models of the carcinogenic process. A case study: methylene chloride.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1469447

7 July 2018

Developmental changes in hepatic activation of dietary mutagens by mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1469447

7 July 2018

Effect of age on the development of cardiac hypertrophy produced by aortic constriction in the rat.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1469447

7 July 2018

Theta, a new class of glutathione transferases purified from rat and man

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1469447

7 July 2018

Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1469447

7 July 2018

The human hepatic cytochromes P450 involved in drug metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1469447

7 July 2018

Age-dependent changes in the morphology of brown adipose tissue in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1469447

7 July 2018

Partition coefficients of some aromatic hydrocarbons and ketones in water, blood and oil

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1469447

7 July 2018

Inhalation exposure to a hepatocarcinogenic concentration of methylene chloride does not induce sustained replicative DNA synthesis in hepatocytes of female B6C3F1 mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1469447

26 October 2018

Sensitivity of physiologically based pharmacokinetic models to variation in model parameters: methylene chloride.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1469447

26 October 2018

Physiologically based pharmacokinetics and the risk assessment process for methylene chloride.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1469447

26 October 2018

Gas Uptake Studies of Deuterium Isotope Effects on Dichloromethane Metabolism in Female B6C3F1 Mice in Vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1469447

26 October 2018

Age-dependent pharmacokinetic changes of ethylenediamine in Fischer 344 rats parallel to a two-year chronic toxicity study

1 reference

https://pubmed.ncbi.nlm.nih.gov/8875160

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolism of inhaled dihalomethanes in vivo: Differentiation of kinetic constants for two independent pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/8875160

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Age and survival of an acute carbon monoxide intoxication: an animal model

1 reference

https://pubmed.ncbi.nlm.nih.gov/8875160

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differences in the influence of diet on hepatic glutathione S-transferase activity and glutathione content between young and old C57 black female mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/8875160

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Changes in metabolism during toxicity tests

1 reference

https://pubmed.ncbi.nlm.nih.gov/8875160

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dose-response relationships of tissue distribution and induction of CYP1A1 and CYP1A2 enzymatic activities following acute exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/8875160

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A study of gender, strain and age differences in mouse liver glutathione-S-transferase

1 reference

https://pubmed.ncbi.nlm.nih.gov/8875160

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1289/EHP.96104858

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8875160%20AND%20SRC:MED&resulttype=core&format=json

20 October 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8875160%20AND%20SRC:MED&resulttype=core&format=json

20 October 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8875160%20AND%20SRC:MED&resulttype=core&format=json

20 October 2019

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