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Androgen biosynthesis from cholesterol to DHEA.
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scholarly article
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Europe PubMed Central
PubMed ID
12573809
retrieved
3 August 2017
review article
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Europe PubMed Central
title
Androgen biosynthesis from cholesterol to DHEA.
(English)
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Europe PubMed Central
PubMed ID
12573809
retrieved
3 August 2017
author name string
Walter L Miller
series ordinal
1
1 reference
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Europe PubMed Central
PubMed ID
12573809
retrieved
3 August 2017
publication date
1 December 2002
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stated in
Europe PubMed Central
PubMed ID
12573809
retrieved
3 August 2017
published in
Molecular and Cellular Endocrinology
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stated in
Europe PubMed Central
PubMed ID
12573809
retrieved
3 August 2017
volume
198
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stated in
Europe PubMed Central
PubMed ID
12573809
retrieved
3 August 2017
issue
1-2
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Europe PubMed Central
PubMed ID
12573809
retrieved
3 August 2017
page(s)
7-14
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Europe PubMed Central
PubMed ID
12573809
retrieved
3 August 2017
cites work
Adrenocortical function in puberty. serum ACTH, cortisol and dehydroepiandrosterone in girls and boys
1 reference
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Crossref
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Steroidogenic acute regulatory protein (StAR) retains activity in the absence of its mitochondrial import sequence: implications for the mechanism of StAR action
1 reference
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Crossref
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Molecular modeling of human P450c17 (17alpha-hydroxylase/17,20-lyase): insights into reaction mechanisms and effects of mutations.
1 reference
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Crossref
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Cytochrome b5 augments the 17,20-lyase activity of human P450c17 without direct electron transfer
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
The mitochondrial environment is required for activity of the cholesterol side-chain cleavage enzyme, cytochrome P450scc.
1 reference
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Crossref
reference URL
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Protein kinase C directly phosphorylates the insulin receptor in vitro and reduces its protein-tyrosine kinase activity
1 reference
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The pathophysiology and genetics of congenital lipoid adrenal hyperplasia.
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Spontaneous feminization in a 46,XX female patient with congenital lipoid adrenal hyperplasia due to a homozygous frameshift mutation in the steroidogenic acute regulatory protein
1 reference
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Crossref
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The active form of the steroidogenic acute regulatory protein, StAR, appears to be a molten globule
1 reference
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Crossref
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Rapid regulation of steroidogenesis by mitochondrial protein import
1 reference
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Crossref
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Targeted disruption of the mouse gene encoding steroidogenic acute regulatory protein provides insights into congenital lipoid adrenal hyperplasia
1 reference
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Cloning and structure of the human adrenodoxin gene
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Binding of steroidogenic acute regulatory protein to synthetic membranes suggests an active molten globule
1 reference
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Crossref
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7 January 2021
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inferred from DOI database lookup
Human cholesterol side-chain cleavage enzyme, P450scc: cDNA cloning, assignment of the gene to chromosome 15, and expression in the placenta
1 reference
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Crossref
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Cytochrome P450c17 (steroid 17 alpha-hydroxylase/17,20 lyase): cloning of human adrenal and testis cDNAs indicates the same gene is expressed in both tissues
1 reference
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Crossref
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Cellular mechanisms of insulin resistance in polycystic ovarian syndrome
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Adrenarche: A Survey of Rodents, Domestic Animals, and Primates
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Hyperandrogenic anovulation (PCOS): a unique disorder of insulin action associated with an increased risk of non-insulin-dependent diabetes mellitus
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Excessive insulin receptor serine phosphorylation in cultured fibroblasts and in skeletal muscle. A potential mechanism for insulin resistance in the polycystic ovary syndrome
1 reference
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Polycystic ovary syndrome as a form of functional ovarian hyperandrogenism due to dysregulation of androgen secretion.
1 reference
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Localization of the human CYP17 gene (cytochrome P450(17 alpha)) to 10q24.3 by fluorescence in situ hybridization and simultaneous chromosome banding
1 reference
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Crossref
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Familial Male Pseudohermaphroditism due to 17–20- Desmolase Deficiency. I.In VivoEndocrine Studies*
1 reference
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Spontaneous puberty in 46,XX subjects with congenital lipoid adrenal hyperplasia. Ovarian steroidogenesis is spared to some extent despite inactivating mutations in the steroidogenic acute regulatory protein (StAR) gene
1 reference
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Crossref
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Studies on the role of protein synthesis in the regulation of corticosterone production by adrenocorticotropic hormone in vivo
1 reference
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Puromycin analogs: action of adrenocorticotropic hormone and the role of glycogen
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The genetic and functional basis of isolated 17,20-lyase deficiency
1 reference
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Crossref
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P450c17 mutations R347H and R358Q selectively disrupt 17,20-lyase activity by disrupting interactions with P450 oxidoreductase and cytochrome b5.
1 reference
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Crossref
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Pitfalls in characterizing P450c17 mutations associated with isolated 17,20-lyase deficiency
1 reference
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Crossref
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Developmental roles of the steroidogenic acute regulatory protein (StAR) as revealed by StAR knockout mice.
1 reference
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Crossref
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https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900363-5
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7 January 2021
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inferred from DOI database lookup
Congenital adrenal hyperplasia due to deficient cholesterol side-chain cleavage activity (20, 22-desmolase) in a patient treated for 18 years.
1 reference
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Crossref
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Congenital lipoid adrenal hyperplasia in an eight-year-old phenotypic female.
1 reference
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Crossref
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Purification and some properties of cytochrome P-450 specific for steroid 17 alpha-hydroxylation and C17-C20 bond cleavage from guinea pig adrenal microsomes
1 reference
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Crossref
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The role of cytochrome b5 in adrenal microsomal steroidogenesis
1 reference
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Crossref
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7 January 2021
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inferred from DOI database lookup
Cloning and sequence of the human adrenodoxin reductase gene
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900363-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Steroid 17 alpha-hydroxylase and 17,20-lyase activities of P450c17: contributions of serine106 and P450 reductase
1 reference
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Crossref
reference URL
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7 January 2021
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inferred from DOI database lookup
Role of steroidogenic acute regulatory protein in adrenal and gonadal steroidogenesis
1 reference
stated in
Crossref
reference URL
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7 January 2021
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inferred from DOI database lookup
Adrenal androgen hyperresponsiveness to adrenocorticotropin in women with acne and/or hirsutism: adrenal enzyme defects and exaggerated adrenarche
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900363-5
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7 January 2021
based on heuristic
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The primate adrenal zona reticularis is defined by expression of cytochrome b5, 17alpha-hydroxylase/17,20-lyase cytochrome P450 (P450c17) and NADPH-cytochrome P450 reductase (reductase) but not 3beta-hydroxysteroid dehydrogenase/...
1 reference
stated in
Crossref
reference URL
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7 January 2021
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inferred from DOI database lookup
Assignment of the gene for adrenal P450c17 (steroid 17 alpha-hydroxylase/17,20 lyase) to human chromosome 10.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900363-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Congenital lipoid adrenal hyperplasia: the human gene knockout for the steroidogenic acute regulatory protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900363-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Molecular biology of steroid hormone synthesis
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
Gene structure of human cytochrome P-450(SCC), cholesterol desmolase
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900363-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Analysis of the steroidogenic acute regulatory protein (StAR) gene in Japanese patients with congenital lipoid adrenal hyperplasia
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900363-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Microsomal cytochrome P-450 from neonatal pig testis: two enzymatic activities (17 alpha-hydroxylase and c17,20-lyase) associated with one protein
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
Cytochrome b5 stimulates purified testicular microsomal cytochrome P-450 (C21 side-chain cleavage)
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900363-5
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7 January 2021
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inferred from DOI database lookup
Age Changes and Sex Differences in Serum Dehydroepiandrosterone Sulfate Concentrations throughout Adulthood
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900363-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Cloning and sequence of the human gene for P450c17 (steroid 17 alpha-hydroxylase/17,20 lyase): similarity with the gene for P450c21
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900363-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Crystal structure of the Mus musculus cholesterol-regulated START protein 4 (StarD4) containing a StAR-related lipid transfer domain
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900363-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Evidence for dissociation between adrenarche and gonadarche: studies in patients with idiopathic precocious puberty, gonadal dysgenesis, isolated gonadotropin deficiency, and constitutionally delayed growth and adolescence
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900363-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Human adrenodoxin reductase: two mRNAs encoded by a single gene on chromosome 17cen----q25 are expressed in steroidogenic tissues
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900363-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Regional mapping of genes encoding human steroidogenic enzymes: P450scc to 15q23-q24, adrenodoxin to 11q22; adrenodoxin reductase to 17q24-q25; and P450c17 to 10q24-q25
1 reference
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Crossref
reference URL
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retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of steroidogenesis in NCI-H295 cells: a cellular model of the human fetal adrenal
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900363-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Studies on ACTH action in perfused bovine adrenals: aspects of progesterone as an intermediary in corticosteroidogenesis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900363-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Human steroidogenic acute regulatory protein: functional activity in COS-1 cells, tissue-specific expression, and mapping of the structural gene to 8p11.2 and a pseudogene to chromosome 13
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900363-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Developmental changes in steroidogenic enzymes in human postnatal adrenal cortex: immunohistochemical studies.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900363-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Structure and lipid transport mechanism of a StAR-related domain
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900363-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Developmental expression of genes for the stereoidogenic enzymes P450scc (20,22-desmolase), P450c17 (17 alpha-hydroxylase/17,20-lyase), and P450c21 (21-hydroxylase) in the human fetus.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900363-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Immunohistochemical study of cytochrome b5 in human adrenal gland and in adrenocortical adenomas from patients with Cushing's syndrome.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900363-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Steroid 17,20-desmolase deficiency: a new cause of male pseudohermaphroditism
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900363-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Serine phosphorylation of human P450c17 increases 17,20-lyase activity: implications for adrenarche and the polycystic ovary syndrome
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900363-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Expression of bovine 17 alpha-hydroxylase cytochrome P-450 cDNA in nonsteroidogenic (COS 1) cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900363-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S0303-7207(02)00363-5
1 reference
stated in
Europe PubMed Central
PubMed ID
12573809
retrieved
3 August 2017
PubMed ID
12573809
1 reference
stated in
Europe PubMed Central
PubMed ID
12573809
retrieved
3 August 2017
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