(Q34653242)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17185229%20AND%20SRC:MED&resulttype=core&format=json

23 December 2019

title

An inhibitor of human asparagine synthetase suppresses proliferation of an L-asparaginase-resistant leukemia cell line (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17185229%20AND%20SRC:MED&resulttype=core&format=json

23 December 2019

1 reference

2

1 reference

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23 December 2019

author name string

Jemy A Gutierrez

1

1 reference

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23 December 2019

Lukasz Koroniak

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17185229%20AND%20SRC:MED&resulttype=core&format=json

23 December 2019

Jun Hiratake

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17185229%20AND%20SRC:MED&resulttype=core&format=json

23 December 2019

Michael S Kilberg

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17185229%20AND%20SRC:MED&resulttype=core&format=json

23 December 2019

Nigel G J Richards

6

1 reference

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23 December 2019

publication date

1 December 2006

1 reference

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23 December 2019

published in

Chemistry and Biology

1 reference

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23 December 2019

volume

13

1 reference

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23 December 2019

issue

12

1 reference

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23 December 2019

page(s)

1339-1347

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17185229%20AND%20SRC:MED&resulttype=core&format=json

Asparagine synthetase chemotherapy

23 December 2019

cites work

1 reference

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Expression levels of asparagine synthetase in blasts from children and adults with acute lymphoblastic leukaemia

7 July 2018

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7 July 2018

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Efficient expression, purification, and characterization of C-terminally tagged, recombinant human asparagine synthetase

7 July 2018

1 reference

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Asparagine synthetase expression is linked with L-asparaginase resistance in TEL-AML1-negative but not TEL-AML1-positive pediatric acute lymphoblastic leukemia

7 July 2018

1 reference

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Using genome-wide transcriptional profiling to elucidate small-molecule mechanism

7 July 2018

1 reference

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A genome-wide view of the in vitro response to l-asparaginase in acute lymphoblastic leukemia.

7 July 2018

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7 July 2018

1 reference

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Revisiting the steady state kinetic mechanism of glutamine-dependent asparagine synthetase from Escherichia coli

7 July 2018

1 reference

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Implicit Solvation Models: Equilibria, Structure, Spectra, and Dynamics

7 July 2018

1 reference

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Multiple adaptive mechanisms affect asparagine synthetase substrate availability in asparaginase-resistant MOLT-4 human leukaemia cells

7 July 2018

1 reference

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X-ray snapshots of serine protease catalysis reveal a tetrahedral intermediate

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3608209

Asparagine synthetase expression alone is sufficient to induce l-asparaginase resistance in MOLT-4 human leukaemia cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3608209

Channeling of substrates and intermediates in enzyme-catalyzed reactions

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3608209

Structural basis for the activity and substrate specificity of Erwinia chrysanthemi L-asparaginase

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3608209

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3608209

Three-dimensional structure of Escherichia coli asparagine synthetase B: a short journey from substrate to product

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3608209

Kinetic mechanism of Escherichia coli asparagine synthetase B.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3608209

Mechanistic issues in asparagine synthetase catalysis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3608209

Enzymes utilizing glutamine as an amide donor.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3608209

Crystal structure of asparagine synthetase reveals a close evolutionary relationship to class II aminoacyl-tRNA synthetase

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3608209

Amino acid control of asparagine synthetase: relation to asparaginase resistance in human leukemia cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3608209

Glutamine-dependent nitrogen transfer in Escherichia coli asparagine synthetase B. Searching for the catalytic triad

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3608209

Structural model for the reaction mechanism of glutamine synthetase, based on five crystal structures of enzyme-substrate complexes

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3608209

l-Asparaginase resistance in human leukemia—Asparagine synthetase

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3608209

L-Asparaginase and L-Asparagine Metabolism

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3608209

The asparagine synthetase of Escherhic coli. I. Biosynthetic role of the enzyme, purification, and characterization of the reaction products.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3608209

Studies on glutamine synthetase from Escherichia coli. Formation of pyrrolidone carboxylate and inhibition by methionine sulfoximine.

7 July 2018

1 reference

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The behavior and significance of slow-binding enzyme inhibitors

7 July 2018

1 reference

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Purification and characterization of beef pancreatic asparagine synthetase.

7 July 2018

1 reference

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MOPAC: a semiempirical molecular orbital program

7 July 2018

1 reference

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Inhibition of Escherichia coli glutamine synthetase by alpha- and gamma-substituted phosphinothricins.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3608209

Investigation of the mechanism of phosphinothricin inactivation of Escherichia coli glutamine synthetase using rapid quench kinetic techniques

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3608209

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

7 July 2018

1 reference

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6 Statistical analysis of enzyme kinetic data

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3608209

Effective dose of L-asparaginase for induction of remission in previously treated children with acute lymphocytic leukemia: a report from Childrens Cancer Study Group

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3608209

Analogs of L-aspartic acid in chemotherapy for cancer

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3608209

Inhibitors of L-asparagine synthetase, in vitro

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3608209

A continuous spectrophotometric assay for argininosuccinate synthetase based on pyrophosphate formation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3608209

Up-regulation of asparagine synthetase expression is not linked to the clinical response L-asparaginase in pediatric acute lymphoblastic leukemia

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3608209

Synthesis and characterization of an N-acylsulfonamide inhibitor of human asparagine synthetase.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3608209

gamma-Glutamyl thioester intermediate in glutaminase reaction catalyzed by Escherichia coli asparagine synthetase B.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3608209

Characterization of inhibitors acting at the synthetase site of Escherichia coli asparagine synthetase B.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3608209

Identification of L-methionine S-sulfoximine as the diastereoisomer of L-methionine SR-sulfoximine that inhibits glutamine synthetase

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3608209

26 October 2018

The amidotransferases

1 reference

12 December 2020

Analytical and preparative separation of the diastereomers of l-buthionine (SR)-sulfoximine, a potent inhibitor of glutathione biosynthesis

1 reference

12 December 2020

Biochemical characterization of U937 cells resistant to L-asparaginase: the role of asparagine synthetase

1 reference

12 December 2020

L-asparaginase therapy in children with advanced leukemia. The Southwest Cancer Chemotherapy Study Group

1 reference

12 December 2020

Management of children with acute lymphoblastic leukemia by the Dana-Farber Cancer Institute protocols. An update of the Ontario experience

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12 December 2020

Dual role for the glutamine phosphoribosylpyrophosphate amidotransferase ammonia channel. Interdomain signaling and intermediate channeling

1 reference

12 December 2020

On the use of isovalued surfaces to determine molecule shape and reaction pathways

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12 December 2020

A combined assay of cell viability and in vitro cytotoxicity with a highly water-soluble tetrazolium salt, neutral red and crystal violet

1 reference

12 December 2020

Glutamine-dependent asparagine synthetase from leukemia cells. Chloride dependence, mechanism of action, and inhibition

1 reference

12 December 2020

Safety aspects of handling the potent allergen FDNB

1 reference

12 December 2020

Effect of the presence of a reversible inhibitor on the time course of slow-binding inhibition

1 reference

12 December 2020

Arginine 30 and asparagine 74 have functional roles in the glutamine dependent activities of Escherichia coli asparagine synthetase B

1 reference

12 December 2020

Terminal deoxynucleotidyl transferase activity in a cell line (Molt-4) derived from the peripheral blood of a patient with acute lymphoblastic leukemia

1 reference

12 December 2020

Amino acid analysis by dinitrophenylation and reverse-phase high-pressure liquid chromatography

1 reference

12 December 2020

Formation and isolation of a covalent intermediate during the glutaminase reaction of a class II amidotransferase

1 reference

12 December 2020

Tight-binding inhibitors-I. Kinetic behavior

1 reference

12 December 2020

Design, synthesis and evaluation of transition-state analogue inhibitors of Escherichia coli gamma-glutamylcysteine synthetase

1 reference

12 December 2020

10.1016/J.CHEMBIOL.2006.10.010

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17185229%20AND%20SRC:MED&resulttype=core&format=json

23 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17185229%20AND%20SRC:MED&resulttype=core&format=json

23 December 2019

1 reference