(Q34668685)

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In vitro and in vivo characterization of the non-peptide NK3 receptor antagonist SB-223412 (talnetant): potential therapeutic utility in the treatment of schizophrenia

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scholarly article

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Europe PubMed Central

3 August 2017

In vitro and in vivo characterization of the non-peptide NK3 receptor antagonist SB-223412 (talnetant): potential therapeutic utility in the treatment of schizophrenia (English)

1 reference

Europe PubMed Central

3 August 2017

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author name string

Lee A Dawson

1

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3 August 2017

Katherine J Cato

2

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3 August 2017

Claire Scott

3

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Europe PubMed Central

3 August 2017

Jeannette M Watson

4

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3 August 2017

Martyn D Wood

5

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3 August 2017

Richard Foxton

6

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3 August 2017

Raúl de la Flor

7

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3 August 2017

Gareth A Jones

8

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Europe PubMed Central

3 August 2017

James Nc Kew

9

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3 August 2017

Jane E Cluderay

10

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Europe PubMed Central

3 August 2017

Eric Southam

11

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Europe PubMed Central

3 August 2017

Graham S Murkitt

12

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Europe PubMed Central

3 August 2017

Jane Gartlon

13

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Europe PubMed Central

3 August 2017

Darrel J Pemberton

14

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3 August 2017

Declan Nc Jones

15

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3 August 2017

Ceri H Davies

16

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3 August 2017

Jim Hagan

17

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3 August 2017

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publication date

29 August 2007

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3 August 2017

number of pages

11

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Neuropsychopharmacology

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3 August 2017

33

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7

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1642-1652

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3 August 2017

https://scigraph.springernature.com/pub.10.1038/sj.npp.1301549

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Presence of NK3-sensitive neurones in different proportions in the medial habenula of guinea-pig, rat and gerbil

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1301549

21 January 2018

The selective NK3 receptor agonist senktide excites a subpopulation of dopamine-sensitive neurones in the rat substantia nigra pars compacta in vitro

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1301549

21 January 2018

The mammalian tachykinin receptors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1301549

21 January 2018

Evidence for modulation of dopamine-neuronal function by tachykinin NK3 receptor stimulation in gerbil mesencephalic cell cultures.

1 reference

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7 January 2021

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BacMam recombinant baculoviruses in G protein-coupled receptor drug discovery

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7 January 2021

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Permissive role of neurokinin NK(3) receptors in NK(1) receptor-mediated activation of the locus coeruleus revealed by SR 142801.

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7 January 2021

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Stepwise modulation of neurokinin-3 and neurokinin-2 receptor affinity and selectivity in quinoline tachykinin receptor antagonists

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https://api.crossref.org/works/10.1038%2FSJ.NPP.1301549

7 January 2021

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Molecular characterisation, expression and localisation of human neurokinin‐3 receptor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1301549

7 January 2021

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Interactions between monoamines, glutamate, and GABA in schizophrenia: new evidence

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1301549

7 January 2021

based on heuristic

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Mesencephalic dopaminergic neurons expressing neuromedin K receptor (NK3): a double immunocytochemical study in the rat.

1 reference

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7 January 2021

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Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1301549

7 January 2021

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Visualization of neurokinin-3 receptor sites in rat brain using the highly selective ligand [3H]senktide

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1301549

7 January 2021

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Phylogeny of tachykinin receptor localization in the vertebrate central nervous system: apparent absence of neurokinin-2 and neurokinin-3 binding sites in the human brain

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1301549

7 January 2021

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GABAergic basal forebrain neurons that express receptor for neurokinin B and send axons to the cerebral cortex

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1301549

7 January 2021

based on heuristic

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Differential autoreceptor control of extracellular 5-HT in guinea pig and rat: species and regional differences

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1301549

7 January 2021

based on heuristic

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Injection of tachykinins and selective neurokinin receptor ligands into the substantia nigra reticulata increases striatal dopamine and 5-hydroxytryptamine metabolism

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1301549

7 January 2021

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Pharmacological characterisation of human 5-HT2 receptor subtypes

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https://api.crossref.org/works/10.1038%2FSJ.NPP.1301549

7 January 2021

based on heuristic

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Electrophysiological, behavioural and biochemical evidence for activation of brain noradrenergic systems following neurokinin NK3 receptor stimulation.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1301549

7 January 2021

based on heuristic

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The distribution of the neurokinin B receptor in the human and rat hypothalamus

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1301549

7 January 2021

based on heuristic

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Detailed distribution of Neurokinin 3 receptors in the rat, guinea pig and gerbil brain: a comparative autoradiographic study

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1301549

7 January 2021

based on heuristic

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Cortical inhibitory neurons and schizophrenia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1301549

7 January 2021

based on heuristic

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Neurokinins activate local glutamatergic inputs to serotonergic neurons of the dorsal raphe nucleus

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1301549

7 January 2021

based on heuristic

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Activation of dopaminergic and cholinergic neurotransmission by tachykinin NK3 receptor stimulation: an in vivo microdialysis approach in guinea pig.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1301549

7 January 2021

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Placebo-controlled evaluation of four novel compounds for the treatment of schizophrenia and schizoaffective disorder

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1301549

7 January 2021

based on heuristic

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Neurokinin-3 receptor distribution in rat and human brain: an immunohistochemical study.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1301549

7 January 2021

based on heuristic

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Tachykinin neurokinin-1 and neurokinin-3 receptor-mediated responses in guinea-pig substantia nigra: an in vitro electrophysiological study.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1301549

7 January 2021

based on heuristic

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NK-3 receptors are expressed on mouse striatal gamma-aminobutyric acid-ergic interneurones and evoke [(3)H] gamma-aminobutyric acid release

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1301549

7 January 2021

based on heuristic

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Characterization of NK-3 binding sites in rat and guinea pig cortical membranes by the selective ligand [3H]Senktide

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1301549

7 January 2021

based on heuristic

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Species differences in tachykinin receptor distribution: further evidence that the substance P (NK1) receptor predominates in human brain

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1301549

7 January 2021

based on heuristic

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Opinion: NK3 receptor antagonists: the next generation of antipsychotics?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1301549

7 January 2021

based on heuristic

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Localization of striatal and nigral tachykinin receptors in the rat.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1301549

7 January 2021

based on heuristic

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Tachykinin NK1 and NK3 receptors in the prefrontal cortex of the human brain

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1301549

7 January 2021

based on heuristic

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Quantitation, cellular localization and regulation of neurokinin receptor gene expression within the rat substantia nigra

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1301549

7 January 2021

based on heuristic

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Localization of Fos-like immunoreactivity induced by the NK3 tachykinin receptor agonist, senktide, in the guinea-pig brain

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1301549

7 January 2021

based on heuristic

inferred from DOI database lookup

Localization of NK1 and NK3 receptors in guinea-pig brain

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1301549

7 January 2021

based on heuristic

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Identifiers

10.1038/SJ.NPP.1301549

1 reference

Europe PubMed Central

3 August 2017

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1 reference

Europe PubMed Central

3 August 2017

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