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A conserved Myc protein domain, MBIV, regulates DNA binding, apoptosis, transformation, and G2 arrest.
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1489101
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16705173%20AND%20SRC:MED&resulttype=core&format=json
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21 January 2020
title
A conserved Myc protein domain, MBIV, regulates DNA binding, apoptosis, transformation, and G2 arrest
(English)
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1489101
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21 January 2020
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apoptotic process
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Victoria Cowling
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1
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1489101
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21 January 2020
Sanjay Chandriani
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2
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1489101
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21 January 2020
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Michael L Whitfield
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3
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1489101
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21 January 2020
Michael D Cole
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4
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21 January 2020
language of work or name
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1 June 2006
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21 January 2020
published in
Molecular and Cellular Biology
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1489101
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21 January 2020
volume
26
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21 January 2020
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11
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21 January 2020
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4226-4239
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21 January 2020
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Evidence that Myc activation depletes the epidermal stem cell compartment by modulating adhesive interactions with the local microenvironment
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Myc recruits P-TEFb to mediate the final step in the transcriptional activation of the cad promoter
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A functional screen for Myc-responsive genes reveals serine hydroxymethyltransferase, a major source of the one-carbon unit for cell metabolism
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TRRAP-dependent and TRRAP-independent transcriptional activation by Myc family oncoproteins
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The proto-oncogene c-myc acts through the cyclin-dependent kinase (Cdk) inhibitor p27(Kip1) to facilitate the activation of Cdk4/6 and early G(1) phase progression
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A novel c-Myc-responsive gene, JPO1, participates in neoplastic transformation
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Binding of c-Myc to chromatin mediates mitogen-induced acetylation of histone H4 and gene activation.
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Regulation of cyclin D2 gene expression by the Myc/Max/Mad network: Myc-dependent TRRAP recruitment and histone acetylation at the cyclin D2 promoter.
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7 July 2018
N-myc enhances the expression of a large set of genes functioning in ribosome biogenesis and protein synthesis
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7 July 2018
The transcriptional program of a human B cell line in response to Myc
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7 July 2018
Complementation of Myc-dependent cell proliferation by cDNA expression library screening
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Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability.
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Overexpression of MYC causes p53-dependent G2 arrest of normal fibroblasts
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Promotion of growth and apoptosis in c-myc nullizygous fibroblasts by other members of the myc oncoprotein family
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Induction of cell cycle progression and acceleration of apoptosis are two separable functions of c-Myc: transrepression correlates with acceleration of apoptosis
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7 July 2018
N-myc can functionally replace c-myc in murine development, cellular growth, and differentiation
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7 July 2018
Expression analysis with oligonucleotide microarrays reveals that MYC regulates genes involved in growth, cell cycle, signaling, and adhesion
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7 July 2018
c-Myc proteolysis by the ubiquitin-proteasome pathway: stabilization of c-Myc in Burkitt's lymphoma cells
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7 July 2018
The essential cofactor TRRAP recruits the histone acetyltransferase hGCN5 to c-Myc
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PubMed Central
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7 July 2018
Oncogene expression cloning by retroviral transduction of adenovirus E1A-immortalized rat kidney RK3E cells: transformation of a host with epithelial features by c-MYC and the zinc finger protein GKLF.
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7 July 2018
c-myc null cells misregulate cad and gadd45 but not other proposed c-Myc targets
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7 July 2018
c-Myc target genes involved in cell growth, apoptosis, and metabolism
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7 July 2018
The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins
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7 July 2018
Phenotypes of c-Myc-deficient rat fibroblasts isolated by targeted homologous recombination.
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7 July 2018
Myc versus USF: discrimination at the cad gene is determined by core promoter elements
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7 July 2018
Drosophila Myc is oncogenic in mammalian cells and plays a role in the diminutive phenotype
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7 July 2018
Myc and Max homologs in Drosophila
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7 July 2018
Hierarchical phosphorylation at N-terminal transformation-sensitive sites in c-Myc protein is regulated by mitogens and in mitosis
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1489101
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7 July 2018
A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins
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7 July 2018
Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes
1 reference
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1489101
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7 July 2018
Functional role for c-myc in mitogenic response to platelet-derived growth factor
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1489101
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7 July 2018
Definition of regions in human c-myc that are involved in transformation and nuclear localization
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1489101
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7 July 2018
The myc oncogene: its role in transformation and differentiation
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1489101
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7 July 2018
DNA-binding domain of human c-Myc produced in Escherichia coli.
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7 July 2018
Definition of the activities and properties of c-myc required to inhibit cell differentiation
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7 July 2018
Sequence-specific DNA binding by the c-Myc protein
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PubMed Central
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7 July 2018
Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc
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7 July 2018
Constitutive c-myc expression in an IL-3-dependent myeloid cell line suppresses cell cycle arrest and accelerates apoptosis
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7 July 2018
Induction of apoptosis in fibroblasts by c-myc protein
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PubMed Central
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7 July 2018
The F-box protein Skp2 participates in c-Myc proteosomal degradation and acts as a cofactor for c-Myc-regulated transcription
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1489101
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26 October 2018
Nmyc upregulation by sonic hedgehog signaling promotes proliferation in developing cerebellar granule neuron precursors
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PubMed Central
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26 October 2018
c-Myc regulates mammalian body size by controlling cell number but not cell size
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1489101
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26 October 2018
Point mutations in the c-Myc transactivation domain are common in Burkitt's lymphoma and mouse plasmacytomas
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1489101
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26 October 2018
Identification and characterization of specific DNA-binding complexes containing members of the Myc/Max/Mad network of transcriptional regulators
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reference URL
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retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Chimaeras of Myc oncoprotein and steroid receptors cause hormone-dependent transformation of cells
1 reference
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PubMed
reference URL
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12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1128/MCB.01959-05
1 reference
stated in
Europe PubMed Central
PMC publication ID
1489101
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16705173%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 January 2020
PMC publication ID
1489101
1 reference
stated in
Europe PubMed Central
PMC publication ID
1489101
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16705173%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 January 2020
PubMed publication ID
16705173
1 reference
stated in
Europe PubMed Central
PMC publication ID
1489101
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16705173%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 January 2020
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