(Q34719537)

4 August 2017

title

Chronic inhibition of pyruvate dehydrogenase in heart triggers an adaptive metabolic response (English)

1 reference

4 August 2017

Kari T Chambers

1

1 reference

4 August 2017

Teresa C Leone

2

1 reference

4 August 2017

Nandakumar Sambandam

3

1 reference

4 August 2017

Attila Kovacs

4

1 reference

4 August 2017

Cory S Wagg

5

1 reference

4 August 2017

Gary D Lopaschuk

6

1 reference

4 August 2017

Brian N Finck

7

1 reference

4 August 2017

Daniel P Kelly

8

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4 August 2017

language of work or name

English

0 references

publication date

14 February 2011

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4 August 2017

number of pages

8

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Journal of Biological Chemistry

inferred from page(s)

published in

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4 August 2017

volume

286

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4 August 2017

issue

13

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4 August 2017

page(s)

11155-11162

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The myocardial contractile response to physiological stress improves with high saturated fat feeding in heart failure

4 August 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064169

AMP-activated protein kinase control of energy metabolism in the ischemic heart

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064169

Nuclear receptors PPARbeta/delta and PPARalpha direct distinct metabolic regulatory programs in the mouse heart

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064169

Cardiomyocyte expression of PPARgamma leads to cardiac dysfunction in mice

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064169

AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064169

Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064169

Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064169

Reduced mitochondrial oxidative capacity and increased mitochondrial uncoupling impair myocardial energetics in obesity

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064169

Metabolic energetics and genetics in the heart

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064169

Mitochondrial energy metabolism in heart failure: a question of balance

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064169

Mouse models of mitochondrial dysfunction and heart failure

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064169

The evolving diabetes burden in the United States

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064169

Transcriptional regulatory circuits controlling mitochondrial biogenesis and function

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064169

Adaptation and maladaptation of the heart in diabetes: Part I: general concepts

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064169

The cardiac phenotype induced by PPARalpha overexpression mimics that caused by diabetes mellitus

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064169

Global and societal implications of the diabetes epidemic

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064169

A novel mouse model of lipotoxic cardiomyopathy

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064169

Lipotoxic heart disease in obese rats: implications for human obesity

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064169

RGS4 causes increased mortality and reduced cardiac hypertrophy in response to pressure overload

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064169

AICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscle

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064169

Starvation and diabetes increase the amount of pyruvate dehydrogenase kinase isoenzyme 4 in rat heart

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064169

Regulation of energy substrate metabolism in the diabetic heart

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064169

Contraction-induced changes in acetyl-CoA carboxylase and 5'-AMP-activated kinase in skeletal muscle

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064169

Myocardial substrate metabolism: implications for diabetic cardiomyopathy

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064169

New type of cardiomyopathy associated with diabetic glomerulosclerosis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064169

Dichloroacetate stimulation of glucose oxidation improves recovery of ischemic rat hearts

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064169

Evidence for cardiomyopathy in familial diabetes mellitus

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064169

Sites of phosphorylation on pyruvate dehydrogenase from bovine kidney and heart

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064169

Adaptation and maladaptation of the heart in diabetes: Part II: potential mechanisms

7 July 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.217349

Overexpression of pyruvate dehydrogenase kinase 4 in heart perturbs metabolism and exacerbates calcineurin-induced cardiomyopathy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.217349

Chronic activation of PPARalpha is detrimental to cardiac recovery after ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.217349

Substrate metabolism as a determinant for postischemic functional recovery of the heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.217349

CD36 Deficiency Rescues Lipotoxic Cardiomyopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.217349

Myocardial fatty acid metabolism: independent predictor of left ventricular mass in hypertensive heart disease

21 January 2018

1 reference

12 December 2020

Endogenous triacylglycerol metabolism in diabetic heart

1 reference

12 December 2020

Diabetic cardiomyopathy

1 reference

12 December 2020

Changes in myoplasmic pH and calcium concentration during exposure to lactate in isolated rat ventricular myocytes

1 reference

12 December 2020

Inherited cardiomyopathies

1 reference

12 December 2020

Pyruvate dehydrogenase influences postischemic heart function

1 reference

12 December 2020

Metabolism of the human heart. II. Studies on fat, ketone and amino acid metabolism

1 reference

12 December 2020

High-fat diet prevents cardiac hypertrophy and improves contractile function in the hypertensive dahl salt-sensitive rat

1 reference

12 December 2020

Myocardial cell death in human diabetes

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M110.217349

1 reference

4 August 2017

1 reference

4 August 2017

1 reference