(Q34754642)

4 August 2017

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title

Recent advances in the synthesis, design and selection of cysteine protease inhibitors (English)

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4 August 2017

author name string

Alejandro Alvarez Hernandez

series ordinal

1

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4 August 2017

William R Roush

series ordinal

2

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4 August 2017

publication date

1 August 2002

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Current Opinion in Chemical Biology

4 August 2017

published in

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4 August 2017

volume

6

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4 August 2017

issue

4

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4 August 2017

page(s)

459-465

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Cysteine Proteases and Their Inhibitors

4 August 2017

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Recent advances in the treatment of rhinovirus infections

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alpha-Ketocarbonyl peptides: a general approach to reactive resin-bound intermediates in the synthesis of peptide isosteres for protease inhibitor screening on solid support

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7 January 2021

Polymer-supported approach for solution-phase synthesis of cysteine trap protease inhibitors: procedure for straightforward optimization of the P1-P1' pocket

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Parallel solution-phase synthesis of mechanism-based cysteine protease inhibitors

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Combinatorial strategies for targeting protein families: application to the proteases

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Parallel solid-phase synthesis of peptidyl Michael acceptors

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Small ring constrained peptidomimetics. Synthesis of epoxy peptidomimetics, inhibitors of cysteine proteases

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7 January 2021

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7 January 2021

Potent second generation vinyl sulfonamide inhibitors of the trypanosomal cysteine protease cruzain

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Identification of dipeptidyl nitriles as potent and selective inhibitors of cathepsin B through structure-based drug design

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Potent and selective cathepsin L inhibitors do not inhibit human osteoclast resorption in vitro

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Discovery and parallel synthesis of a new class of cathepsin K inhibitors

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Novel, nonpeptidic cyanamides as potent and reversible inhibitors of human cathepsins K and L.

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A selective cysteine protease inhibitor is non-toxic and cerebroprotective in rats undergoing transient middle cerebral artery ischemia

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7 January 2021

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Analysis of the S(2) subsite specificities of the recombinant cysteine proteinases CPB of Leishmania mexicana, and cruzain of Trypanosoma cruzi, using fluorescent substrates containing non-natural basic amino acids

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7 January 2021

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7 January 2021

Cathepsins X and B can be differentiated through their respective mono- and dipeptidyl carboxypeptidase activities

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7 January 2021

Potent peptide alpha-ketohydroxamate inhibitors of recombinant human calpain I

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7 January 2021

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7 January 2021

Calpain inhibitors based on the quiescent affinity label concept: high rates of calpain inactivation with leaving groups derived from N-hydroxy peptide coupling reagents

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7 January 2021

Synthesis and biological evaluation of novel piperidine carboxamide derived calpain inhibitors

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7 January 2021

1,2-Benzothiazine 1,1-dioxide P(2)-P(3) peptide mimetic aldehyde calpain I inhibitors

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7 January 2021

(S)-Thiirancarboxylic acid as a reactive building block for a new class of cysteine protease inhibitors

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7 January 2021

Vinyl sulfonium as novel proteolytic enzyme inhibitor

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7 January 2021

Structure-based design of caspase-1 inhibitor containing a diphenyl ether sulfonamide

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7 January 2021

N-nitrosoanilines: a new class of caspase-3 inhibitors

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7 January 2021

Discovery, total synthesis, HRV 3C-protease inhibitory activity, and structure-activity relationships of 2-methoxystypandrone and its analogues

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7 January 2021

Design and synthesis of irreversible depsipeptidyl human rhinovirus 3C protease inhibitors.

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7 January 2021

Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. Part 7: structure-activity studies of bicyclic 2-pyridone-containing peptidomimetics

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7 January 2021

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Identifiers

DOI

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4 August 2017

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