(Q34769445)

4 August 2017

title

Modulation of protein kinase signaling cascades by palytoxin (English)

1 reference

4 August 2017

author name string

Elizabeth V Wattenberg

series ordinal

1

1 reference

4 August 2017

publication date

9 November 2010

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4 August 2017

number of pages

9

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inferred from page(s)

published in

Toxicon

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4 August 2017

volume

57

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4 August 2017

issue

3

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4 August 2017

page(s)

440-448

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The cytotoxic pathway triggered by palytoxin involves a change in the cellular pool of stress response proteins

4 August 2017

cites work

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7 July 2018

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7 July 2018

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Enhancement of transformed foci and induction of prostaglandins in Balb/c 3T3 cells by palytoxin: in vitro model reproduces carcinogenic responses in animal models regarding the inhibitory effect of indomethacin and reversal of indomethacin's effect

7 July 2018

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7 July 2018

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Extracellular signal-regulated kinases phosphorylate mitogen-activated protein kinase phosphatase 3/DUSP6 at serines 159 and 197, two sites critical for its proteasomal degradation

7 July 2018

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7 July 2018

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Stress-activated protein kinases-tumor suppressors or tumor initiators?

7 July 2018

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ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions

7 July 2018

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Mitogen-activated protein kinase phosphatase-3 is a tumor promoter target in initiated cells that express oncogenic Ras.

7 July 2018

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7 July 2018

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Inducible expression of a MAP kinase phosphatase-3-GFP chimera specifically blunts fibroblast growth and ras-dependent tumor formation in nude mice

7 July 2018

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Tumor promoter-induced MMP-13 gene expression in a model of initiated epidermis

7 July 2018

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Na+-K+--ATPase-mediated signal transduction: from protein interaction to cellular function

7 July 2018

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Mitogen activated protein kinases selectively regulate palytoxin-stimulated gene expression in mouse keratinocytes

7 July 2018

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Gene profiling of a myeloma cell line reveals similarities and unique signatures among IL-6 response, N-ras-activating mutations, and coculture with bone marrow stromal cells

7 July 2018

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Molecular mechanisms of Na/K-ATPase-mediated signal transduction

7 July 2018

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Potential tumor suppressive pathway involving DUSP6/MKP-3 in pancreatic cancer

7 July 2018

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An analysis of the phosphorylation and activation of extracellular-signal-regulated protein kinase 5 (ERK5) by mitogen-activated protein kinase kinase 5 (MKK5) in vitro

7 July 2018

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Regulation of c-Fos and Fra-1 by the MEK5-ERK5 pathway

7 July 2018

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A pivotal role for ERK in the oncogenic behaviour of malignant melanoma?

7 July 2018

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Extracellular signal-regulated kinase transmits palytoxin-stimulated signals leading to altered gene expression in mouse keratinocytes

7 July 2018

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7 July 2018

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The role of mitogen-activated protein (MAP) kinase in breast cancer

7 July 2018

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Functional roles of Akt signaling in mouse skin tumorigenesis.

7 July 2018

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7 July 2018

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Extracellular signal regulated kinase 5 (ERK5) is required for the differentiation of muscle cells

7 July 2018

1 reference

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Pancreatic tumor cells with mutant K-ras suppress ERK activity by MEK-dependent induction of MAP kinase phosphatase-2.

7 July 2018

1 reference

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MEKK2 associates with the adapter protein Lad/RIBP and regulates the MEK5-BMK1/ERK5 pathway

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3072206

Protein phosphatases and the regulation of mitogen-activated protein kinase signalling.

7 July 2018

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Dual specificity phosphatases: a gene family for control of MAP kinase function.

7 July 2018

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MEKK3 directly regulates MEK5 activity as part of the big mitogen-activated protein kinase 1 (BMK1) signaling pathway

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3072206

Activation of the protein kinase ERK5/BMK1 by receptor tyrosine kinases. Identification and characterization of a signaling pathway to the nucleus

7 July 2018

1 reference

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Transgenic mice demonstrate AP-1 (activator protein-1) transactivation is required for tumor promotion

7 July 2018

1 reference

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Constitutive activation of the 41-/43-kDa mitogen-activated protein kinase signaling pathway in human tumors

7 July 2018

1 reference

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Bmk1/Erk5 is required for cell proliferation induced by epidermal growth factor

7 July 2018

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Differential activation of mitogen-activated protein kinases by palytoxin and ouabain, two ligands for the Na+,K+-ATPase

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3072206

The pathogenesis of squamous cell cancer: lessons learned from studies of skin carcinogenesis

7 July 2018

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Loss of cellular K+ mimics ribotoxic stress. Inhibition of protein synthesis and activation of the stress kinases SEK1/MKK4, stress-activated protein kinase/c-Jun NH2-terminal kinase 1, and p38/HOG1 by palytoxin

7 July 2018

1 reference

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BMK1/ERK5 regulates serum-induced early gene expression through transcription factor MEF2C

7 July 2018

1 reference

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Regulation of a c-Jun amino-terminal kinase/stress-activated protein kinase cascade by a sodium-dependent signal transduction pathway

7 July 2018

1 reference

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AP-1 function and regulation

7 July 2018

1 reference

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Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways.

7 July 2018

1 reference

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Purification and identification of a major activator for p38 from osmotically shocked cells. Activation of mitogen-activated protein kinase kinase 6 by osmotic shock, tumor necrosis factor-alpha, and H2O2

7 July 2018

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Big mitogen-activated protein kinase 1 (BMK1) is a redox-sensitive kinase

7 July 2018

1 reference

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MKP-3, a novel cytosolic protein-tyrosine phosphatase that exemplifies a new class of mitogen-activated protein kinase phosphatase

7 July 2018

1 reference

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Cloning and characterization of MEK6, a novel member of the mitogen-activated protein kinase kinase cascade

7 July 2018

1 reference

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MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway

7 July 2018

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Characterization of the structure and function of a novel MAP kinase kinase (MKK6)

7 July 2018

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Activation of ternary complex factor Elk-1 by stress-activated protein kinases

7 July 2018

1 reference

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Critical aspects of initiation, promotion, and progression in multistage epidermal carcinogenesis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3072206

Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3072206

MAPKs: new JNK expands the group

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3072206

Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3072206

Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3072206

Components of a new human protein kinase signal transduction pathway

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3072206

Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2

7 July 2018

1 reference

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Primary structure of BMK1: a new mammalian map kinase

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3072206

Mouse skin carcinomas induced in vivo by chemical carcinogens have a transforming Harvey-ras oncogene

7 July 2018

1 reference

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Tumor promoters block tyrosine-specific phosphorylation of the epidermal growth factor receptor

7 July 2018

1 reference

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The role of protein kinase C in cell surface signal transduction and tumour promotion

7 July 2018

1 reference

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Development of murine epidermal cell lines which contain an activated rasHa oncogene and form papillomas in skin grafts on athymic nude mouse hosts

7 July 2018

1 reference

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Effects of palytoxin or ouabain on growth and squamous differentiation of human bronchial epithelial cells in vitro.

7 July 2018

1 reference

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Heterologous regulation of the epidermal growth factor receptor by palytoxin, a non-12-O-tetradecanoylphorbol-13-acetate-type tumor promoter

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3072206

Palytoxin is a non-12-O-tetradecanoylphorbol-13-acetate type tumor promoter in two-stage mouse skin carcinogenesis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3072206

Palytoxin acts through Na+,K+-ATPase

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3072206

Sodium as a mediator of non-phorbol tumor promoter action. Down-modulation of the epidermal growth factor receptor by palytoxin

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3072206

Palytoxin down-modulates the epidermal growth factor receptor through a sodium-dependent pathway

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3072206

The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation

7 July 2018

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3072206

7 July 2018

12 December 2020

Identification of MAPKAP kinase 2 as a major enzyme responsible for the phosphorylation of the small mammalian heat shock proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3072206

p44 mitogen-activated protein kinase (extracellular signal-regulated kinase 1)-dependent signaling contributes to epithelial skin carcinogenesis.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3072206

Mitogen-actived protein kinase activation is an early event in melanoma progression.

26 October 2018

1 reference

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Activated extracellular signal-regulated kinases: association with epidermal growth factor receptor/transforming growth factor alpha expression in head and neck squamous carcinoma and inhibition by anti-epidermal growth factor receptor treatments

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3072206

Sustained activation of the mitogen-activated protein kinase pathway. A mechanism underlying receptor tyrosine kinase specificity for matrix metalloproteinase-9 induction and cell migration.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3072206

Activation of stress-activator protein kinase/c-Jun N-terminal kinase by the non-TPA-type tumor promoter palytoxin

26 October 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3072206

Structure-activity studies of the nonphorbol tumor promoter palytoxin in Swiss 3T3 cells.

26 October 2018

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Cell-Type-Specific Activation of p38 Protein Kinase Cascades by the Novel Tumor Promoter Palytoxin

26 October 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3072206

Integration of MAP kinase signal transduction pathways at the serum response element

26 October 2018

1 reference

PubMed

12 December 2020

Constitutive activation of extracellular signal-regulated kinase in human acute leukemias: combined role of activation of MEK, hyperexpression of extracellular signal-regulated kinase, and downregulation of a phosphatase, PAC1

1 reference

PubMed

12 December 2020

Nakahara memorial lecture. New classes of tumor promoters: teleocidin, aplysiatoxin, and palytoxin

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PubMed

12 December 2020

10.1016/J.TOXICON.2010.11.003

Identifiers

DOI

1 reference

4 August 2017

1 reference

4 August 2017

1 reference