(Q34770217)

4 August 2017

title

The in vitro pharmacological profile of TD-5108, a selective 5-HT(4) receptor agonist with high intrinsic activity (English)

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4 August 2017

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J A M Smith

1

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4 August 2017

D T Beattie

2

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4 August 2017

D Marquess

3

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4 August 2017

J P Shaw

4

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4 August 2017

R G Vickery

5

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4 August 2017

P P A Humphrey

6

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4 August 2017

publication date

16 April 2008

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Naunyn-Schmiedeberg's Archives of Pharmacology

4 August 2017

published in

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4 August 2017

volume

378

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4 August 2017

issue

1

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4 August 2017

page(s)

125-137

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Functional evidence for a 5‐HT2B receptor mediating contraction of longitudinal muscle in human small intestine

4 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1007%2FS00210-008-0282-Y

Investigation into the effects of mosapride on motility of Guinea pig stomach, ileum, and colon

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00210-008-0282-Y

Electrophysiological and antiarrhythmic effects of the atrial selective 5-HT(4) receptor antagonist RS-100302 in experimental atrial flutter and fibrillation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-008-0282-Y

Investigation into the 5-hydroxytryptamine receptor mediating smooth muscle relaxation in the rat oesophagus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-008-0282-Y

Tegaserod, a 5-HT4 receptor partial agonist, decreases sensitivity to rectal distension in healthy subjects

21 January 2018

1 reference

12 December 2020

5-Hydroxytryptamine4 receptor agonists initiate the peristaltic reflex in human, rat, and guinea pig intestine

1 reference

12 December 2020

Structure of the human serotonin 5-HT4 receptor gene and cloning of a novel 5-HT4 splice variant

1 reference

12 December 2020

Cloning, pharmacological characterisation and tissue distribution of a novel 5-HT4 receptor splice variant, 5-HT4(i).

1 reference

12 December 2020

Distinct 5-HT receptors mediate the peristaltic reflex induced by mucosal stimuli in human and guinea pig intestine

1 reference

12 December 2020

[3H]RS-23597-190, a potent 5-hydroxytryptamine4 antagonist labels sigma-1 but not sigma-2 binding sites in guinea pig brain

1 reference

12 December 2020

5-hydroxytryptamine 2B receptor regulates cell-cycle progression: cross-talk with tyrosine kinase pathways

1 reference

12 December 2020

Tegaserod-induced myocardial infarction: case report and hypothesis

1 reference

12 December 2020

Identification and stimulation by serotonin of intrinsic sensory neurons of the submucosal plexus of the guinea pig gut: activity-induced expression of Fos immunoreactivity

1 reference

12 December 2020

Long-term efficacy of oral cisapride in symptomatic upper gut dysmotility.

1 reference

12 December 2020

Pharmacological characterization of 5-HT4 receptors mediating relaxation of canine isolated rectum circular smooth muscle

1 reference

12 December 2020

Effect of different prokinetic agents and a novel enterokinetic agent on postoperative ileus in rats

1 reference

12 December 2020

Review article: tegaserod

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12 December 2020

Tegaserod, a 5-HT(4) receptor partial agonist, relieves symptoms in irritable bowel syndrome patients with abdominal pain, bloating and constipation

1 reference

12 December 2020

Nitric oxide is produced via 5-HT1B and 5-HT2B receptor activation in human coronary artery endothelial cells

1 reference

12 December 2020

Effects of mosapride citrate, a 5-HT4 receptor agonist, on colonic motility in conscious guinea pigs

1 reference

12 December 2020

5-hydroxytryptamine receptors in the human cardiovascular system

1 reference

12 December 2020

The 5-HT4 receptor agonist, tegaserod, is a potent 5-HT2B receptor antagonist in vitro and in vivo

1 reference

12 December 2020

5-HT(2A) receptors: location and functional analysis in intestines of wild-type and 5-HT(2A) knockout mice

1 reference

12 December 2020

Involvement of the serotonin 5-HT2B receptor in cardiac hypertrophy linked to sympathetic stimulation: control of interleukin-6, interleukin-1beta, and tumor necrosis factor-alpha cytokine production by ventricular fibroblasts

1 reference

12 December 2020

Signal transduction pathways for serotonin as an intestinal secretagogue

1 reference

12 December 2020

5-HT(2B) receptors play a key role in mediating the excitatory effects of 5-HT in human colon in vitro

1 reference

12 December 2020

Unaltered agonist potency upon inducible 5-HT7(a) but not 5-HT4(b) receptor expression indicates agonist-independent association of 5-HT7(a) receptor and Gs.

1 reference

12 December 2020

Human colonic mucosa possesses a mixed population of 5-HT receptors

1 reference

12 December 2020

Novel brain-specific 5-HT4 receptor splice variants show marked constitutive activity: role of the C-terminal intracellular domain

1 reference

12 December 2020

Pharmacology and metabolism of renzapride : a novel therapeutic agent for the potential treatment of irritable bowel syndrome

1 reference

12 December 2020

Serotonin: a mediator of the brain-gut connection

1 reference

12 December 2020

Evidence for a multivalent interaction of symmetrical, N-linked, lidocaine dimers with voltage-gated Na+ channels

1 reference

12 December 2020

Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

1 reference

12 December 2020

Tegaserod, a 5-hydroxytryptamine type 4 receptor partial agonist, is devoid of electrocardiographic effects

1 reference

12 December 2020

Characterization of human 5-HT4(d) receptor desensitization in CHO cells

1 reference

12 December 2020

Prucalopride is a partial agonist through human and porcine atrial 5-HT4 receptors: comparison with recombinant human 5-HT4 splice variants

1 reference

12 December 2020

Differences in signal transduction of two 5-HT4 receptor splice variants: compound specificity and dual coupling with Galphas- and Galphai/o-proteins

1 reference

12 December 2020

A highly sensitive adenylate cyclase assay

1 reference

12 December 2020

Identification of putative 5-HT4 receptors in guinea-pig ascending colon

1 reference

12 December 2020

Tegaserod for the treatment of irritable bowel syndrome

1 reference

12 December 2020

Cloning and characterization of a novel human 5-HT4 receptor variant that lacks the alternatively spliced carboxy terminal exon. RT-PCR distribution in human brain and periphery of multiple 5-HT4 receptor variants

1 reference

12 December 2020

Treatment of chronic constipation with cisapride and placebo

1 reference

12 December 2020

Cisapride in the management of chronic functional dyspepsia: a multicenter, double-blind, placebo-controlled study

1 reference

12 December 2020

Tegaserod, a 5-HT4 receptor partial agonist, accelerates gastric emptying and gastrointestinal transit in healthy male subjects

1 reference

12 December 2020

Differential functional effects of two 5-HT4 receptor isoforms in adult cardiomyocytes.

1 reference

12 December 2020

Desperately seeking serotonin... A commentary on the withdrawal of tegaserod and the state of drug development for functional and motility disorders

1 reference

12 December 2020

A comparison of the pharmacological properties of guinea-pig and human recombinant 5-HT4 receptors

1 reference

12 December 2020

[3H]BIMU-1, a 5-hydroxytryptamine3 receptor ligand in NG-108 cells, selectively labels sigma-2 binding sites in guinea pig hippocampus.

1 reference

12 December 2020

Isolation of the serotoninergic 5-HT4(e) receptor from human heart and comparative analysis of its pharmacological profile in C6-glial and CHO cell lines

1 reference

12 December 2020

Effects of the enterokinetic prucalopride (R093877) on colonic motility in fasted dogs

1 reference

12 December 2020

Rationale for using serotonergic agents to treat irritable bowel syndrome.

1 reference

12 December 2020

Participation of 5-HT3, 5-HT4, and nicotinic receptors in the peristaltic reflex of guinea pig distal colon

1 reference

12 December 2020

Quantitative mRNA analysis of five C-terminal splice variants of the human 5-HT4 receptor in the central nervous system by TaqMan real time RT-PCR.

1 reference

12 December 2020

Cloning, expression, and pharmacology of four human 5-hydroxytryptamine 4 receptor isoforms produced by alternative splicing in the carboxyl terminus

1 reference

12 December 2020

Prucalopride is effective in patients with severe chronic constipation in whom laxatives fail to provide adequate relief. Results of a double-blind, placebo-controlled clinical trial

1 reference

12 December 2020

The serotonin signaling system: from basic understanding to drug development for functional GI disorders

1 reference

12 December 2020

5-Hydroxytryptamine4 receptors mediate relaxation of the rat oesophageal tunica muscularis mucosae

1 reference

12 December 2020

Tegaserod accelerates orocecal transit in patients with constipation-predominant irritable bowel syndrome

1 reference

12 December 2020

The in vivo gastrointestinal activity of TD-5108, a selective 5-HT(4) receptor agonist with high intrinsic activity

1 reference

12 December 2020

The action of cisapride on gastric emptying and the pharmacodynamics and pharmacokinetics of oral diazepam

1 reference

12 December 2020

5-HT4 receptor activation induces relaxation and associated cAMP generation in rat esophagus

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12 December 2020

5HT4(a) and 5-HT4(b) receptors have nearly identical pharmacology and are both expressed in human atrium and ventricle

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12 December 2020

Propulsion in guinea pig colon induced by 5-hydroxytryptamine (HT) via 5-HT4 and 5-HT3 receptors.

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12 December 2020

Differential effects of 5-hydroxytryptamine4 receptor agonists at gastric versus cardiac receptors: an operational framework to explain and quantify organ-specific behavior

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12 December 2020

Comparison of 5-HT4 receptors in guinea-pig colon and rat oesophagus: effects of novel agonists and antagonists

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12 December 2020

10.1007/S00210-008-0282-Y

Identifiers

DOI

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Dimensions Publication ID

4 August 2017

1014998213

0 references

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