(Q34772498)

4 August 2017

1 reference

title

The peroxisome proliferator-activated receptor alpha (PPARalpha): role in hepatocarcinogenesis (English)

1 reference

4 August 2017

Frank J Gonzalez

1

1 reference

4 August 2017

1 July 2002

1 reference

Molecular and Cellular Endocrinology

4 August 2017

1 reference

4 August 2017

193

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4 August 2017

71-79

1 reference

4 August 2017

1-2

1 reference

Hepatocellular proliferation in response to a peroxisome proliferator does not require TNFalpha signaling

4 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900098-9

7 January 2021

Altered constitutive expression of fatty acid-metabolizing enzymes in mice lacking the peroxisome proliferator-activated receptor alpha (PPARalpha)

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900098-9

7 January 2021

Molecular basis of non-responsiveness to peroxisome proliferators: the guinea-pig PPARalpha is functional and mediates peroxisome proliferator-induced hypolipidaemia

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900098-9

7 January 2021

Influence of fenofibrate on cellular and subcellular liver structure in hyperlipidemic patients

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900098-9

7 January 2021

Do peroxisome proliferating compounds pose a hepatocarcinogenic hazard to humans?

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900098-9

7 January 2021

PPAR-gamma dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900098-9

7 January 2021

PPAR-alpha and PPAR-gamma activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900098-9

7 January 2021

Transformation of mammalian cells by overexpressing H2O2-generating peroxisomal fatty acyl-CoA oxidase

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900098-9

7 January 2021

Differences in the steady-state levels of c-fos, c-jun and c-myc messenger RNA during mitogen-induced liver growth and compensatory regeneration

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900098-9

7 January 2021

A dominant negative form of IKK2 prevents suppression of apoptosis by the peroxisome proliferator nafenopin

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900098-9

7 January 2021

Alterations in DNA methylation may play a variety of roles in carcinogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900098-9

7 January 2021

Hypomethylation of DNA: a nongenotoxic mechanism involved in tumor promotion

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900098-9

7 January 2021

Light and electron microscopy of liver in hyperlipoproteinemic patients under long-term gemfibrozil treatment

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900098-9

7 January 2021

The pleiotropic functions of peroxisome proliferator-activated receptor gamma

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900098-9

7 January 2021

Induction of solid tumor differentiation by the peroxisome proliferator-activated receptor-gamma ligand troglitazone in patients with liposarcoma

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900098-9

7 January 2021

Control of the peroxisomal β-oxidation pathway by a novel family of nuclear hormone receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900098-9

7 January 2021

Peroxisome proliferation due to di(2-ethylhexyl) phthalate (DEHP): species differences and possible mechanisms

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900098-9

7 January 2021

Morphometric study of human hepatic cell modifications induced by fenofibrate

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900098-9

7 January 2021

A Truncated Human Peroxisome Proliferator-Activated Receptor Splice Variant with Dominant Negative Activity

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900098-9

7 January 2021

Potential roles of the peroxisome proliferator-activated receptor-gamma in macrophage biology and atherosclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900098-9

7 January 2021

Prostacyclin-mediated activation of peroxisome proliferator-activated receptor delta in colorectal cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900098-9

7 January 2021

Relationship between morphological changes and lipid-lowering action of p-chlorphenoxyisobutyric acid (CPIB) on hepatic mitochondria and peroxisomes in man

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900098-9

7 January 2021

Species differences in response to diethylhexylphthalate: suppression of apoptosis, induction of DNA synthesis and peroxisome proliferator activated receptor alpha-mediated gene expression

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900098-9

7 January 2021

Role of hepatic non-parenchymal cells in the response of rat hepatocytes to the peroxisome proliferator nafenopin in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900098-9

7 January 2021

PPARdelta is an APC-regulated target of nonsteroidal anti-inflammatory drugs

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900098-9

7 January 2021

No measurable increase in thymidine glycol or 8-hydroxydeoxyguanosine in liver DNA of rats treated with nafenopin or choline-devoid low-methionine diet

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900098-9

7 January 2021

Biological esterification of steroids.

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900098-9

7 January 2021

Identification of peroxisome proliferator-responsive human genes by elevated expression of the peroxisome proliferator-activated receptor alpha in HepG2 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900098-9

7 January 2021

Cloning of novel members of the steroid hormone receptor superfamily.

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900098-9

7 January 2021

The Interaction of C-17 Esters of Estradiol with the Estrogen Receptor*

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900098-9

7 January 2021

Differential expression and activation of a family of murine peroxisome proliferator-activated receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900098-9

7 January 2021

Tumor necrosis factor alpha is not required for WY14,643-induced cell proliferation

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900098-9

7 January 2021

Progress in cardiovascular biology: PPAR for the course

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900098-9

7 January 2021

In vivo hepatocyte proliferation is inducible through a TNF and IL-6-independent pathway.

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900098-9

7 January 2021

Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900098-9

7 January 2021

Expression of the Peroxisome Proliferator-activated Receptor Gene Is Stimulated by Stress and Follows a Diurnal Rhythm

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900098-9

7 January 2021

PPAR delta functions as a prostacyclin receptor in blastocyst implantation

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900098-9

7 January 2021

Biochemical mechanisms of induction of hepatic peroxisome proliferation

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900098-9

7 January 2021

https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900098-9

1 reference

7 January 2021

Lack of comitogenicity by the peroxisome proliferator hepatocarcinogens, Wy-14,643 and clofibric acid

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900098-9

7 January 2021

Human and rat peroxisome proliferator activated receptors (PPARs) demonstrate similar tissue distribution but different responsiveness to PPAR activators

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900098-9

7 January 2021

PPAR-gamma agonists: therapeutic role in diabetes, inflammation and cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900098-9

7 January 2021

A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900098-9

7 January 2021

Peroxisome proliferator activated receptor-alpha expression in human liver.

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900098-9

7 January 2021

Genetic disruption of PPARdelta decreases the tumorigenicity of human colon cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900098-9

7 January 2021

Peroxisome proliferators do not increase DNA synthesis in purified rat hepatocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900098-9

7 January 2021

Role of PPAR alpha in the mechanism of action of the nongenotoxic carcinogen and peroxisome proliferator Wy-14,643.

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900098-9

7 January 2021

Role of peroxisome proliferator-activated receptor alpha in altered cell cycle regulation in mouse liver.

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900098-9

7 January 2021

Growth, adipose, brain, and skin alterations resulting from targeted disruption of the mouse peroxisome proliferator-activated receptor beta(delta)

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900098-9

7 January 2021

Peroxisome proliferator-activated receptor alpha is restricted to hepatic parenchymal cells, not Kupffer cells: implications for the mechanism of action of peroxisome proliferators in hepatocarcinogenesis.

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900098-9

7 January 2021

Carcinogenesis by Hepatic Peroxisome Proliferators: Evaluation of the Risk of Hypolipidemic Drugs and Industrial Plasticizers to Humans

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900098-9

7 January 2021

Oxidative DNA damage caused by persistent peroxisome proliferation: its role in hepatocarcinogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900098-9

7 January 2021

Role of cytokines in non-genotoxic hepatocarcinogenesis: cause or effect?

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900098-9

7 January 2021

Role of Kupffer cells and oxidants in signaling peroxisome proliferator-induced hepatocyte proliferation

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900098-9

7 January 2021

Expression of base excision repair enzymes in rat and mouse liver is induced by peroxisome proliferators and is dependent upon carcinogenic potency.

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900098-9

7 January 2021

The human peroxisome proliferator-activated receptor alpha gene: identification and functional characterization of two natural allelic variants.

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900098-9

7 January 2021

cDNA cloning, chromosomal mapping, and functional characterization of the human peroxisome proliferator activated receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900098-9

7 January 2021

PPAR-gamma: adipogenic regulator and thiazolidinedione receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900098-9

7 January 2021

PPARgamma promotes monocyte/macrophage differentiation and uptake of oxidized LDL

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900098-9

7 January 2021

Identification of a peroxisome proliferator-responsive element upstream of the human peroxisomal fatty acyl coenzyme A oxidase gene

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900098-9

7 January 2021

The peroxisome proliferator-activated receptor delta promotes lipid accumulation in human macrophages

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900098-9

7 January 2021

Peroxisome proliferator-activated receptor gamma and metabolic disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900098-9

7 January 2021

Risk assessment of inhaled chloroform based on its mode of action

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900098-9

7 January 2021

Human peroxisome proliferator-activated receptor alpha (PPARalpha) supports the induction of peroxisome proliferation in PPARalpha-deficient mouse liver

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900098-9

7 January 2021

10.1016/S0303-7207(02)00098-9

Identifiers

DOI

1 reference

4 August 2017

1 reference

PubMed ID

12161004