(Q34774491)

English

Activation of 3-phosphoinositide-dependent kinase 1 (PDK1) and serum- and glucocorticoid-induced protein kinase 1 (SGK1) by short-chain sphingolipid C4-ceramide rescues the trafficking defect of ΔF508-cystic fibrosis transmembrane conductance regula

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scholarly article

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Europe PubMed Central

PubMed publication ID

4 August 2017

Activation of 3-phosphoinositide-dependent kinase 1 (PDK1) and serum- and glucocorticoid-induced protein kinase 1 (SGK1) by short-chain sphingolipid C4-ceramide rescues the trafficking defect of ΔF508-cystic fibrosis transmembrane conductance regula (English)

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

transmembrane protein

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cystic fibrosis

0 references

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

author name string

Hung Caohuy

1

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

Qingfeng Yang

2

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

Yvonne Eudy

3

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

Thien-An Ha

4

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

Andrew E Xu

5

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

Matthew Glover

6

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

Raymond A Frizzell

7

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

Catherine Jozwik

8

1 reference

Europe PubMed Central

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4 August 2017

Harvey B Pollard

9

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Europe PubMed Central

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4 August 2017

language of work or name

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publication date

10 November 2014

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Europe PubMed Central

PubMed publication ID

4 August 2017

Journal of Biological Chemistry

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Europe PubMed Central

PubMed publication ID

4 August 2017

289

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

52

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

35953-35968

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

ARF6 regulates neuron differentiation through glucosylceramide synthase

1 reference

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1 reference

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Pharmacological rescue of the mutant cystic fibrosis transmembrane conductance regulator (CFTR) detected by use of a novel fluorescence platform

1 reference

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Correction of the F508del-CFTR protein processing defect in vitro by the investigational drug VX-809.

1 reference

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High-throughput screening of libraries of compounds to identify CFTR modulators.

1 reference

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Elevated miR-155 promotes inflammation in cystic fibrosis by driving hyperexpression of interleukin-8

1 reference

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An overview of sphingolipid metabolism: from synthesis to breakdown

1 reference

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7 July 2018

The V510D suppressor mutation stabilizes DeltaF508-CFTR at the cell surface.

1 reference

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The nuts and bolts of AGC protein kinases

1 reference

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Modulation of endocytic trafficking and apical stability of CFTR in primary human airway epithelial cultures

1 reference

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Rescue of DeltaF508-CFTR by the SGK1/Nedd4-2 signaling pathway

1 reference

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Chain length specificity for activation of cPLA2alpha by C1P: use of the dodecane delivery system to determine lipid-specific effects.

1 reference

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mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4276863

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A secondary assay for ceramide kinase inhibitors based on cell growth inhibition by short-chain ceramides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4276863

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Development of a small-molecule serum- and glucocorticoid-regulated kinase-1 antagonist and its evaluation as a prostate cancer therapeutic.

1 reference

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Long-chain ceramide is a potent inhibitor of the mitochondrial permeability transition pore

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4276863

7 July 2018

Ceramide accumulation mediates inflammation, cell death and infection susceptibility in cystic fibrosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4276863

7 July 2018

Fenretinide corrects newly found ceramide deficiency in cystic fibrosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4276863

7 July 2018

Regulation of human cystic fibrosis transmembrane conductance regulator (CFTR) by serum- and glucocorticoid-inducible kinase (SGK1).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4276863

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Pharmacologic characterization of a potent inhibitor of class I phosphatidylinositide 3-kinases.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4276863

7 July 2018

The mammalian phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) regulates endosome-to-TGN retrograde transport.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4276863

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The coordination of prostaglandin E2 production by sphingosine-1-phosphate and ceramide-1-phosphate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4276863

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Exploitation of KESTREL to identify NDRG family members as physiological substrates for SGK1 and GSK3

1 reference

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7 July 2018

cAMP and serum and glucocorticoid-inducible kinase (SGK) regulate the epithelial Na(+) channel through convergent phosphorylation of Nedd4-2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4276863

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Digitoxin mimics gene therapy with CFTR and suppresses hypersecretion of IL-8 from cystic fibrosis lung epithelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4276863

7 July 2018

Endocytic trafficking routes of wild type and DeltaF508 cystic fibrosis transmembrane conductance regulator

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4276863

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Ceramide 1-phosphate is a direct activator of cytosolic phospholipase A2

1 reference

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Sphingoid base signaling via Pkh kinases is required for endocytosis in yeast

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The PIF-binding pocket in PDK1 is essential for activation of S6K and SGK, but not PKB.

1 reference

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Natural ceramide reverses Fas resistance of acid sphingomyelinase(-/-) hepatocytes.

1 reference

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A phosphoserine-regulated docking site in the protein kinase RSK2 that recruits and activates PDK1.

1 reference

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Phosphorylation of Ser-241 is essential for the activity of 3-phosphoinositide-dependent protein kinase-1: identification of five sites of phosphorylation in vivo

1 reference

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Cystic fibrosis as a disease of misprocessing of the cystic fibrosis transmembrane conductance regulator glycoprotein

1 reference

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Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2

1 reference

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Functional counterparts of mammalian protein kinases PDK1 and SGK in budding yeast

1 reference

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Stimulation of DNA synthesis by natural ceramide 1-phosphate

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Subcellular distribution and metabolic fate of exogenous ceramides taken up by HL-60 cells

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Cystic fibrosis fatty acid imbalance is linked to ceramide deficiency and corrected by fenretinide.

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PIKfyve sensitivity of hERG channels.

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Regulation of endocytic recycling of KCNQ1/KCNE1 potassium channels

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1 reference

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1 reference

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Induction of apoptotic DNA fragmentation and cell death by natural ceramide

1 reference

https://pubmed.ncbi.nlm.nih.gov/25384981

12 December 2020

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inferred from PubMed ID database lookup

(1S,2R)-D-erythro-2-(N-myristoylamino)-1-phenyl-1-propanol as an inhibitor of ceramidase

1 reference

https://pubmed.ncbi.nlm.nih.gov/25384981

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inferred from PubMed ID database lookup

Cystic fibrosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/25384981

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Identifiers

10.1074/JBC.M114.598649

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

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